3-oxo-3-(arylamino)propanoates, a process for their preparation, and their use in preparing pyrrolidinones

ABSTRACT

Disclosed are compounds of Formula I, including all stereoisomers and salts thereof, 
                         
wherein Q 1 , Q 2  and R are as defined in the disclosure.
 
     Also disclosed is a method for preparing a compound of Formula I, comprising contacting a compound of Formula II 
     
       
         
         
             
             
         
       
         
         
           
             with a compound of Formula III 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             optionally in the presence of a catalyst or a base to form a compound of Formula I. Further disclosed is a method for preparing a compound of Formula IV, 
           
         
       
    
                         
comprising reductively cyclizing a compound of Formula I in the presence of a reducing agent.

BACKGROUND OF THE INVENTION

This invention relates to certain 3-oxo-3-(arylamino)propanoates, their salts and compositions, a process to prepare them and their use in preparing certain pyrrolidinones useful as herbicides.

SUMMARY OF THE INVENTION

This invention is directed to a compound of Formula I and salts thereof

wherein

-   -   Q¹ is a phenyl ring or a naphthalenyl ring system, each ring or         ring system optionally substituted with up to 5 substituents         independently selected from R¹; or a 5- to 6-membered fully         unsaturated heterocyclic ring or an 8- to 10-membered         heteroaromatic bicyclic ring system, each ring or ring system         containing ring members selected from carbon atoms and 1 to 4         heteroatoms independently selected from up to 2 O, up to 2 S and         up to 4 N atoms, wherein up to 3 carbon ring members are         independently selected from C(═O) and C(═S), and the sulfur atom         ring members are independently selected from         S(═O)_(u)(═NR²)_(v), each ring or ring system optionally         substituted with up to 5 substituents independently selected         from R¹ on carbon atom ring members and selected from R³ on         nitrogen atom ring members;     -   Q² is a phenyl ring or a naphthalenyl ring system, each ring or         ring system optionally substituted with up to 5 substituents         independently selected from R⁴; or a 5- to 6-membered fully         unsaturated heterocyclic ring or an 8- to 10-membered         heteroaromatic bicyclic ring system, each ring or ring system         containing ring members selected from carbon atoms and 1 to 4         heteroatoms independently selected from up to 2 O, up to 2 S and         up to 4 N atoms, wherein up to 3 carbon ring members are         independently selected from C(═O) and C(═S), and the sulfur atom         ring members are independently selected from         S(═O)_(u)(═NR²)_(v), each ring or ring system optionally         substituted with up to 5 substituents independently selected         from R⁴ on carbon atom ring members and selected from R⁵ on         nitrogen atom ring members;     -   R is C₁-C₈ alkyl or phenyl;     -   each R¹ and R⁴ is independently halogen, cyano, nitro, C₁-C₈         alkyl, C₁-C₈ haloalkyl, C₁-C₈ nitroalkyl, C₂-C₈ alkenyl, C₂-C₈         haloalkenyl, C₂-C₈ haloalkoxyalkoxy, C₂-C₈ nitroalkenyl, C₂-C₈         alkynyl, C₂-C₈ haloalkynyl, C₄-C₁₀ cycloalkylalkyl, C₄-C₁₀         halocycloalkylalkyl, C₅-C₁₂ alkylcycloalkylalkyl, C₅-C₁₂         cycloalkylalkenyl, C₅-C₁₂ cycloalkylalkynyl, C₃-C₈ cycloalkyl,         C₃-C₈ halocycloalkyl, C₄-C₁₀ alkylcycloalkyl, C₆-C₁₂         cycloalkylcycloalkyl, C₃-C₈ cycloalkenyl, C₃-C₈         halocycloalkenyl, C₂-C₈ alkoxyalkyl, C₂-C₈ haloalkoxyalkyl,         C₄-C₁₀ cycloalkoxyalkyl, C₃-C₁₀ alkoxyalkoxyalkyl, C₂-C₈         alkylthioalkyl, C₂-C₈ alkylsulfinylalkyl, C₂-C₈         alkylsulfonylalkyl, C₂-C₈ alkylaminoalkyl, C₂-C₈         haloalkylaminoalkyl, C₄-C₁₀ cycloalkylaminoalkyl, C₃-C₁₀         dialkylaminoalkyl, —CHO, C₂-C₈ alkylcarbonyl, C₂-C₈         haloalkylcarbonyl, C₄-C₁₀ cycloalkylcarbonyl, —C(═O)OH, C₂-C₈         alkoxycarbonyl, C₂-C₈ haloalkoxycarbonyl, C₄-C₁₀         cycloalkoxycarbonyl, C₅-C₁₂ cycloalkylalkoxycarbonyl, —C(═O)NH₂,         C₂-C₈ alkylaminocarbonyl, C₄-C₁₀ cycloalkylaminocarbonyl, C₃-C₁₀         dialkylaminocarbonyl, C₁-C₈ alkoxy, C₁-C₈ haloalkoxy, C₂-C₈         alkoxyalkoxy, C₂-C₈ alkenyloxy, C₂-C₈ haloalkenyloxy, C₃-C₈         alkynyloxy, C₃-C₈ haloalkynyloxy, C₃-C₈ cycloalkoxy, C₃-C₈         halocycloalkoxy, C₄-C₁₀ cycloalkylalkoxy, C₃-C₁₀         alkylcarbonylalkoxy, C₂-C₈ alkylcarbonyloxy, C₂-C₈         haloalkylcarbonyloxy, C₄-C₁₀ cycloalkylcarbonyloxy, C₁-C₈         alkylsulfonyloxy, C₁-C₈ haloalkylsulfonyloxy, C₁-C₈ alkylthio,         C₁-C₈ haloalkylthio, C₃-C₈ cycloalkylthio, C₁-C₈ alkylsulfinyl,         C₁-C₈ haloalkylsulfinyl, C₁-C₈ alkylsulfonyl, C₁-C₈         haloalkylsulfonyl, C₃-C₈ cycloalkylsulfonyl, formylamino, C₂-C₈         alkylcarbonylamino, C₂-C₈ haloalkylcarbonylamino, C₂-C₈         alkoxycarbonylamino, C₁-C₆ alkylsulfonylamino, C₁-C₆         haloalkylsulfonylamino, —SF₅, —SCN, C₃-C₁₂ trialkylsilyl, C₄-C₁₂         trialkylsilylalkyl or C₄-C₁₂ trialkylsilylalkoxy;     -   each R² is independently H, cyano, C₂-C₃ alkylcarbonyl or C₂-C₃         haloalkylcarbonyl;     -   each R³ and R⁵ is independently cyano, C₁-C₃ alkyl, C₂-C₃         alkenyl, C₂-C₃ alkynyl, C₃-C₆ cycloalkyl, C₂-C₃ alkoxyalkyl,         C₁-C₃ alkoxy, C₂-C₃ alkylcarbonyl, C₂-C₃ alkoxycarbonyl, C₂-C₃         alkylaminoalkyl, C₃-C₄ dialkylaminoalkyl or C₂-C₃ haloalkyl; and     -   each u and v are independently 0, 1 or 2 in each instance of         S(═O)_(u)(═NR²)_(v), provided that the sum of u and v is 0, 1 or         2.

This invention also relates to a method for preparing a compound of Formula I, comprising contacting a compound of Formula II

with a compound of Formula III

optionally in the presence of a catalyst or a base to form a compound of Formula I.

This invention further relates to a method for preparing a compound of Formula IV

comprising reductively cyclizing a compound of Formula I in the presence of a reducing agent.

DETAILS OF THE INVENTION

As used herein, the terms “comprises,” “comprising,” “includes,” “including,” “has,” “having,” “contains”, “containing,” “characterized by” or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated. For example, a composition, mixture, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process, method, article, or apparatus.

The transitional phrase “consisting of” excludes any element, step, or ingredient not specified. If in the claim, such would close the claim to the inclusion of materials other than those recited except for impurities ordinarily associated therewith. When the phrase “consisting of” appears in a clause of the body of a claim, rather than immediately following the preamble, it limits only the element set forth in that clause; other elements are not excluded from the claim as a whole.

The transitional phrase “consisting essentially of” is used to define a composition, method or apparatus that includes materials, steps, features, components, or elements, in addition to those literally disclosed, provided that these additional materials, steps, features, components, or elements do not materially affect the basic and novel characteristic(s) of the claimed invention. The term “consisting essentially of” occupies a middle ground between “comprising” and “consisting of”.

Where applicants have defined an invention or a portion thereof with an open-ended term such as “comprising,” it should be readily understood that (unless otherwise stated) the description should be interpreted to also describe such an invention using the terms “consisting essentially of” or “consisting of.”

Further, unless expressly stated to the contrary, “or” refers to an inclusive or and not to an exclusive or. For example, a condition A or B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present).

Also, the indefinite articles “a” and “an” preceding an element or component of the invention are intended to be nonrestrictive regarding the number of instances (i.e. occurrences) of the element or component. Therefore “a” or “an” should be read to include one or at least one, and the singular word form of the element or component also includes the plural unless the number is obviously meant to be singular.

In the above recitations, the term “alkyl”, used either alone or in compound words such as “alkylthio” or “haloalkyl” includes straight-chain or branched alkyl, such as, methyl, ethyl, n-propyl, i-propyl, or the different butyl, pentyl or hexyl isomers. “Alkenyl” includes straight-chain or branched alkenes such as ethenyl, 1-propenyl, 2-propenyl, and the different butenyl, pentenyl and hexenyl isomers. “Alkenyl” also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl. “Alkynyl” includes straight-chain or branched alkynes such as ethynyl, 1-propynyl, 2-propynyl and the different butynyl, pentynyl and hexynyl isomers. “Alkynyl” can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl.

“Alkoxy” includes, for example, methoxy, ethoxy, n-propyloxy, isopropyloxy and the different butoxy, pentoxy and hexyloxy isomers. “Alkoxyalkyl” denotes alkoxy substitution on alkyl. Examples of “alkoxyalkyl” include CH₃OCH₂, CH₃OCH₂CH₂, CH₃CH₂OCH₂, CH₃CH₂CH₂CH₂OCH₂ and CH₃CH₂OCH₂CH₂. “Alkoxyalkoxy” denotes alkoxy substitution on alkoxy. “Alkenyloxy” includes straight-chain or branched alkenyloxy moieties. Examples of “alkenyloxy” include H₂C═CHCH₂O, (CH₃)₂C═CHCH₂O, (CH₃)CH═CHCH₂O, (CH₃)CH═C(CH₃)CH₂O and CH₂═CHCH₂CH₂O. “Alkynyloxy” includes straight-chain or branched alkynyloxy moieties. Examples of “alkynyloxy” include HC≡CCH₂O, CH₃C≡CCH₂O and CH₃C≡CCH₂CH₂O. “Alkylthio” includes branched or straight-chain alkylthio moieties such as methylthio, ethylthio, and the different propylthio, butylthio, pentylthio and hexylthio isomers. “Alkylsulfinyl” includes both enantiomers of an alkylsulfinyl group. Examples of “alkylsulfinyl” include CH₃S(O)—, CH₃CH₂S(O)—, CH₃CH₂CH₂S(O)—, (CH₃)₂CHS(O)— and the different butylsulfinyl, pentylsulfinyl and hexylsulfinyl isomers. Examples of “alkyl sulfonyl” include CH₃S(O)₂—, CH₃CH₂S(O)₂—, CH₃CH₂CH₂S(O)₂—, (CH₃)₂CHS(O)₂—, and the different butylsulfonyl, pentylsulfonyl and hexylsulfonyl isomers. “Alkylthioalkyl” denotes alkylthio substitution on alkyl. Examples of “alkylthioalkyl” include CH₃SCH₂, CH₃SCH₂CH₂, CH₃CH₂SCH₂, CH₃CH₂CH₂CH₂SCH₂ and CH₃CH₂SCH₂CH₂. “Alkylamino”, “Alkylaminoalkyl”, and the like, are defined analogously to the above examples.

“Cycloalkyl” includes, for example, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. The term “alkylcycloalkyl” denotes alkyl substitution on a cycloalkyl moiety and includes, for example, ethylcyclopropyl, i-propylcyclobutyl, 3-methylcyclopentyl and 4-methylcyclohexyl. The term “cycloalkylalkyl” denotes cycloalkyl substitution on an alkyl moiety. Examples of “cycloalkylalkyl” include cyclopropylmethyl, cyclopentylethyl, and other cycloalkyl moieties bonded to straight-chain or branched alkyl groups. The term “cycloalkoxy” denotes cycloalkyl linked through an oxygen atom such as cyclopentyloxy and cyclohexyloxy. “Cycloalkylalkoxy” denotes cycloalkylalkyl linked through an oxygen atom attached to the alkyl chain. Examples of “cycloalkylalkoxy” include cyclopropylmethoxy, cyclopentylethoxy, and other cycloalkyl moieties bonded to straight-chain or branched alkoxy groups.

The term “halogen”, either alone or in compound words such as “haloalkyl”, or when used in descriptions such as “alkyl substituted with halogen” includes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as “haloalkyl”, or when used in descriptions such as “alkyl substituted with halogen” said alkyl may be partially or fully substituted with halogen atoms which may be the same or different. Examples of “haloalkyl” or “alkyl substituted with halogen” include F₃C, ClCH₂, CF₃CH₂ and CF₃CCl₂. The terms “halocycloalkyl”, “haloalkoxy”, “haloalkylthio”, “haloalkenyl”, “haloalkynyl”, and the like, are defined analogously to the term “haloalkyl”. Examples of “haloalkoxy” include CF₃O—, CCl₃CH₂O—, HCF₂CH₂CH₂O— and CF₃CH₂O—. Examples of “haloalkylthio” include CCl₃S—, CF₃S—, CCl₃CH₂S— and ClCH₂CH₂CH₂S—. Examples of “haloalkylsulfinyl” include CF₃S(O)—, CCl₃S(O)—, CF₃CH₂S(O)— and CF₃CF₂S(O)—. Examples of “haloalkylsulfonyl” include CF₃S(O)₂—, CCl₃S(O)₂—, CF₃CH₂S(O)₂— and CF₃CF₂S(O)₂—. Examples of “haloalkenyl” include (Cl)₂C═CHCH₂— and CF₃CH₂CH═CH═CH₂—. Examples of “haloalkynyl” include HC≡CCHCl—, CF₃C≡C—, CCl₃C≡C— and FCH₂C≡CCH₂—. Examples of “haloalkoxyalkoxy” include CF₃OCH₂O—, ClCH₂CH₂OCH₂CH₂O—, Cl₃CCH₂OCH₂O— as well as branched alkyl derivatives.

“Alkylcarbonyl” denotes a straight-chain or branched alkyl moieties bonded to a C(═O) moiety. Examples of “alkylcarbonyl” include CH₃C(═O)—, CH₃CH₂CH₂C(═O)— and (CH₃)₂CHC(═O)—. Examples of “alkoxycarbonyl” include CH₃OC(═O)—, CH₃CH₂OC(═O)—, CH₃CH₂CH₂OC(═O)—, (CH₃)₂CHOC(═O)— and the different butoxy- or pentoxycarbonyl isomers.

The total number of carbon atoms in a substituent group is indicated by the “C_(i)-C_(j)” prefix where i and j are numbers from 1 to 12. For example, C₁-C₄ alkylsulfonyl designates methylsulfonyl through butylsulfonyl; C₂ alkoxyalkyl designates CH₃OCH₂—; C₃ alkoxyalkyl designates, for example, CH₃CH(OCH₃)—, CH₃OCH₂CH₂— or CH₃CH₂OCH₂—; and C₄ alkoxyalkyl designates the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CH₃CH₂CH₂OCH₂— and CH₃CH₂OCH₂CH₂—.

When a compound is substituted with a substituent bearing a subscript that indicates the number of said substituents can exceed 1, said substituents (when they exceed 1) are independently selected from the group of defined substituents, e.g., ([R¹)_(n)], n is 0, 1, 2, 3, 4 or 5). When a group contains a substituent which can be hydrogen, for example Q¹, then when this substituent is taken as hydrogen, it is recognized that this is equivalent to said group being unsubstituted. When a variable group is shown to be optionally attached to a position, for example R¹, then hydrogen may be at the position even if not recited in the variable group definition. When one or more positions on a group are said to be “not substituted” or “unsubstituted”, then hydrogen atoms are attached to take up any free valency.

The expression “fully saturated” in relation to a ring of atoms means that the bonds between the atoms of the ring are all single. The expression “fully unsaturated” in relation to a ring means that the bonds between the atoms in the ring are single or double bonds according to valence bond theory and furthermore the bonds between the atoms in the ring include as many double bonds as possible without double bonds being cumulative (i.e. no C═C═C, N═C═C, etc.). The term “partially unsaturated” in relation to a ring denotes a ring comprising at least one ring member bonded to an adjacent ring member though a double bond and which conceptually potentially accommodates a number of non-cumulated double bonds through adjacent ring members (i.e. in its fully unsaturated counterpart form) greater than the number of double bonds present (i.e. in its partially unsaturated form). When a fully unsaturated ring satisfies Hückel's rule then it can also be described as aromatic.

Unless otherwise indicated, a “ring” or “ring system” as a component of Formula I (e.g., substituent Q¹) is carbocyclic or heterocyclic. The term “ring system” denotes two or more fused rings. The term “bicyclic ring system” denotes a ring system consisting of two fused rings, in which either ring can be saturated, partially unsaturated, or fully unsaturated unless otherwise indicated. The term “heteroaromatic bicyclic ring system” denotes a bicyclic ring system in which at least one ring atom is not carbon. The term “ring member” refers to an atom or other moiety (e.g., C(═O), C(═S), S(O) or S(O)₂) forming the backbone of a ring or ring system.

The terms “carbocyclic ring” denotes a ring or ring system wherein the atoms forming the ring backbone are selected only from carbon. Unless otherwise indicated, a carbocyclic ring can be a saturated, partially unsaturated, or fully unsaturated ring. When a fully unsaturated carbocyclic ring satisfies Hückel's rule, then said ring is also called an “aromatic ring”.

The term “heterocyclic ring” denotes a ring or ring system in which at least one atom forming the ring backbone is not carbon, e.g., nitrogen, oxygen or sulfur. Typically a heterocyclic ring contains no more than 4 nitrogens, no more than 2 oxygens and no more than 2 sulfurs. Unless otherwise indicated, a heterocyclic ring can be a saturated, partially unsaturated, or fully unsaturated ring. When a fully unsaturated heterocyclic ring satisfies Hückel's rule, then said ring is also called a “heteroaromatic ring” or “aromatic heterocyclic ring”. Unless otherwise indicated, heterocyclic rings and ring systems can be attached through any available carbon or nitrogen by replacement of a hydrogen on said carbon or nitrogen.

“Aromatic” indicates that each of the ring atoms is essentially in the same plane and has a p-orbital perpendicular to the ring plane, and that (4n+2) π electrons, where n is a positive integer, are associated with the ring to comply with Hückel's rule.

The term “optionally substituted” in connection with the heterocyclic rings refers to groups which are unsubstituted or have at least one non-hydrogen substituent that does not extinguish the biological activity possessed by the unsubstituted analog. As used herein, the following definitions shall apply unless otherwise indicated. The term “optionally substituted” is used interchangeably with the phrase “substituted or unsubstituted” or with the term “(un)substituted.” Unless otherwise indicated, an optionally substituted group may have a substituent at each substitutable position of the group, and each substitution is independent of the other.

When Q¹ and Q² is a 5- or 6-membered nitrogen-containing heterocyclic ring, it may be attached to the remainder of Formula I though any available carbon or nitrogen ring atom, unless otherwise described. As noted above, Q¹ or Q² can be (among others) phenyl optionally substituted with one or more substituents selected from a group of substituents as defined in the Summary of the Invention. An example of phenyl optionally substituted with one to five substituents is the ring illustrated as U-1 in Exhibit 1, wherein, for example, R^(v) is R¹ as defined in the Summary of the Invention for Q¹, or R^(v) is R⁴ as defined in the Summary of the Invention for Q², and r is an integer (from 0 to 5).

As noted above, Q¹ and Q² can be (among others) 5- or 6-membered fully unsaturated heterocyclic ring, optionally substituted with one or more substituents selected from a group of substituents as defined in the Summary of the Invention. Examples of a 5- or 6-membered fully unsaturated heterocyclic ring optionally substituted with from one or more substituents include the rings U-2 through U-61 illustrated in Exhibit 1 wherein R^(v) is any substituent as defined in the Summary of the Invention for Q¹ (i.e. R¹ or R³) or Q² (i.e. R⁴ or R⁵) and r is an integer from 0 to 4, limited by the number of available positions on each U group. As U-29, U-30, U-36, U-37, U-38, U-39, U-40, U-41, U-42 and U-43 have only one available position, for these U groups r is limited to the integers 0 or 1, and r being 0 means that the U group is unsubstituted and a hydrogen is present at the position indicated by (R^(v))_(r).

As noted above, Q¹ and Q² can be (among others) an 8- to 10-membered heteroaromatic bicyclic ring system optionally substituted with one or more substituents selected from a group of substituents as defined in the Summary of the Invention for Q¹ and Q². Examples of an 8- to 10-membered heteroaromatic bicyclic ring system optionally substituted with one or more substituents include the rings U-62 through U-100 illustrated in Exhibit 2 wherein R^(v) is any substituent as defined in the Summary of the Invention for Q¹ or Q², and r is typically an integer from 0 to 4.

Although R^(v) groups are shown in the structures U-1 through U-100, it is noted that they do not need to be present since they are optional substituents. Note that when R^(v) is H when attached to an atom, this is the same as if said atom is unsubstituted. The nitrogen atoms that require substitution to fill their valence are substituted with H or R^(v). Note that when the attachment point between (R^(v))_(r) and the U group is illustrated as floating, (R^(v))_(r) can be attached to any available carbon atom or nitrogen atom of the U group. Note that when the attachment point on the U group is illustrated as floating, the U group can be attached to the remainder of Formula I through any available carbon or nitrogen of the U group by replacement of a hydrogen atom. Note that some U groups can only be substituted with less than 4 R^(v) groups (e.g., U-2 through U-5, U-7 through U-48, and U-52 through U-61).

A wide variety of synthetic methods are known in the art to enable preparation of aromatic and nonaromatic heterocyclic rings and ring systems; for extensive reviews see the eight volume set of Comprehensive Heterocyclic Chemistry, A. R. Katritzky and C. W. Rees editors-in-chief, Pergamon Press, Oxford, 1984 and the twelve volume set of Comprehensive Heterocyclic Chemistry II, A. R. Katritzky, C. W. Rees and E. F. V. Scriven editors-in-chief, Pergamon Press, Oxford, 1996.

Compounds of this invention can exist as one or more stereoisomers. The various stereoisomers include enantiomers, diastereomers, atropisomers and geometric isomers. Stereoisomers are isomers of identical constitution but differing in the arrangement of their atoms in space and include enantiomers, diastereomers, cis-trans isomers (also known as geometric isomers) and atropisomers. Atropisomers result from restricted rotation about single bonds where the rotational barrier is high enough to permit isolation of the isomeric species. One skilled in the art will appreciate that one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s). Additionally, the skilled artisan knows how to separate, enrich, and/or to selectively prepare said stereoisomers. The compounds of the invention may be present as a mixture of stereoisomers, individual stereoisomers or as an optically active form.

For example the C(O)N(Q²)(R⁶) moiety (bonded to the carbon at the 3-position of the pyrrolidinone ring) and Q¹ (bonded to the carbon at the 4-position of the pyrrolidinone ring) are generally found in the trans configuration. These two carbon atoms (i.e. at the 3- and 4-positions each posses the pyrroldinone ring of Formula IV) both possess a chiral center. The two most prevelant pairs of enantiomers are depicted as Formula IV′ and Formula IV″ where the chiral centers are identified (i.e. as 3R, 4S or as 3S, 4R). While this invention pertains to all stereoisomers, the preferred enantiomeric pair for biological operability is identified as Formula IV′ (i.e. the 3R, 4S configuration). For a comprehensive discussion of all aspects of stereoisomerism, see Ernest L. Eliel and Samuel H. Wilen, Stereochemistry of Organic Compounds, John Wiley & Sons, 1994.

Molecular depictions drawn herein follow standard conventions for depicting stereochemistry. To indicate stereoconfiguration, bonds rising from the plane of the drawing and towards the viewer are denoted by solid wedges wherein the broad end of the wedge is attached to the atom rising from the plane of the drawing towards the viewer. Bonds going below the plane of the drawing and away from the viewer are denoted by dashed wedges wherein the narrow end of the wedge is attached to the atom further away from the viewer. Constant width lines indicate bonds with a direction opposite or neutral relative to bonds shown with solid or dashed wedges; constant width lines also depict bonds in molecules or parts of molecules in which no particular stereoconfiguration is intended to be specified. This invention comprises racemic mixtures, for example, equal amounts of the enantiomers of Formulae IV′ and IV″. In addition, this invention includes compounds that are enriched compared to the racemic mixture in an enantiomer of Formula IV. Also included are the essentially pure enantiomers of compounds of Formula I, for example, Formula IV′ and Formula IV″.

When enantiomerically enriched, one enantiomer is present in greater amounts than the other, and the extent of enrichment can be defined by an expression of enentiomeric ratio (ER) expressed as the relative area % of the two entantiomers determined by chiral high-performance liquid chromatography.

Preferably the compositions of this invention have at least a 50% ER; more preferably at least a 75% ER; still more preferably at least a 90% ER; and the most preferably at least a 94% ER of the more active isomer. Of particular note are enantiomerically pure embodiments of the more active isomer.

Compounds of Formula IV can comprise additional chiral centers. For example, substituents and other molecular constituents such as R¹, R³, R⁴ and R⁵ may themselves contain chiral centers. This invention comprises racemic mixtures as well as enriched and essentially pure stereoconfigurations at these additional chiral centers.

Compounds of this invention can exist as one or more conformational isomers due to restricted rotation about the amide bond (e.g., C(O)—N) in Formula I and IV. This invention comprises mixtures of conformational isomers. In addition, this invention includes compounds that are enriched in one conformer relative to others.

Compounds of Formula I typically exist in more than one form, and Formula I thus include all crystalline and non-crystalline forms of the compounds they represent. Non-crystalline forms include embodiments which are solids such as waxes and gums as well as embodiments which are liquids such as solutions and melts. Crystalline forms include embodiments which represent essentially a single crystal type and embodiments which represent a mixture of polymorphs (i.e. different crystalline types). The term “polymorph” refers to a particular crystalline form of a chemical compound that can crystallize in different crystalline forms, these forms having different arrangements and/or conformations of the molecules in the crystal lattice. Although polymorphs can have the same chemical composition, they can also differ in composition due the presence or absence of co-crystallized water or other molecules, which can be weakly or strongly bound in the lattice. Polymorphs can differ in such chemical, physical and biological properties as crystal shape, density, hardness, color, chemical stability, melting point, hygroscopicity, suspensibility, dissolution rate and biological availability. One skilled in the art will appreciate that a polymorph of a compound of Formula I can exhibit beneficial effects (e.g., suitability for preparation of useful formulations, improved biological performance) relative to another polymorph or a mixture of polymorphs of the same compound of Formula I. Preparation and isolation of a particular polymorph of a compound of Formula I can be achieved by methods known to those skilled in the art including, for example, crystallization using selected solvents and temperatures. For a comprehensive discussion of polymorphism see R. Hilfiker, Ed., Polymorphism in the Pharmaceutical Industry, Wiley-VCH, Weinheim, 2006.

One skilled in the art will appreciate that not all nitrogen-containing heterocycles can form N-oxides since the nitrogen requires an available lone pair for oxidation to the oxide; one skilled in the art will recognize those nitrogen-containing heterocycles which can form N-oxides. One skilled in the art will also recognize that tertiary amines can form N-oxides. Synthetic methods for the preparation of N-oxides of heterocycles and tertiary amines are very well known by one skilled in the art including the oxidation of heterocycles and tertiary amines with peroxy acids such as peracetic and m-chloroperbenzoic acid (MCPBA), hydrogen peroxide, alkyl hydroperoxides such as t-butyl hydroperoxide, sodium perborate, and dioxiranes such as dimethyldioxirane. These methods for the preparation of N-oxides have been extensively described and reviewed in the literature, see for example: T. L. Gilchrist in Comprehensive Organic Synthesis, vol. 7, pp 748-750, S. V. Ley, Ed., Pergamon Press; M. Tisler and B. Stanovnik in Comprehensive Heterocyclic Chemistry, vol. 3, pp 18-20, A. J. Boulton and A. McKillop, Eds., Pergamon Press; M. R. Grimmett and B. R. T. Keene in Advances in Heterocyclic Chemistry, vol. 43, pp 149-161, A. R. Katritzky, Ed., Academic Press; M. Tisler and B. Stanovnik in Advances in Heterocyclic Chemistry, vol. 9, pp 285-291, A. R. Katritzky and A. J. Boulton, Eds., Academic Press; and G. W. H. Cheeseman and E. S. G. Werstiuk in Advances in Heterocyclic Chemistry, vol. 22, pp 390-392, A. R. Katritzky and A. J. Boulton, Eds., Academic Press.

One skilled in the art recognizes that because in the environment and under physiological conditions salts of chemical compounds are in equilibrium with their corresponding nonsalt forms, salts share the biological utility of the nonsalt forms. Thus a wide variety of salts of a compound of Formula I are useful for control of undesired vegetation (i.e. are agriculturally suitable). The salts of a compound of Formula I include acid-addition salts with inorganic or organic acids such as hydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic, butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic, tartaric, 4-toluenesulfonic or valeric acids. When a compound of Formula I contains an acidic moiety such as a carboxylic acid or phenol, salts also include those formed with organic or inorganic bases such as pyridine, triethylamine or ammonia, or amides, hydrides, hydroxides or carbonates of sodium, potassium, lithium, calcium, magnesium or barium. Accordingly, the present invention comprises compounds selected from Formula I, N-oxides and agriculturally suitable salts thereof.

Embodiments of the present invention as described in the Summary of the Invention include (where Formula I as used in the following Embodiments includes N-oxides and salts thereof):

-   -   Embodiment A1. A compound of Formula I as described in the         Summary of Invention.     -   Embodiment A2. A compound of Embodiment A1 wherein Q¹ is a         phenyl ring optionally substituted with up to 5 substituents         independently selected from R¹.     -   Embodiment A3. A compound of Embodiment A2 wherein Q¹ is a         phenyl ring substituted with 1 to 4 substituents independently         selected from R¹.     -   Embodiment A4. A compound of Embodiment A3 wherein Q¹ is a         phenyl ring substituted with 1 to 3 substituents independently         selected from R¹.     -   Embodiment A5. A compound of any one of Embodiments A1 through         A4 wherein Q¹ is a phenyl ring having a substituent selected         from R¹ at the meta (3-) position and optionally up to 2         additional R¹ substituents.     -   Embodiment A6. A compound of any one of Embodiments A1 through         A4 wherein Q¹ is a phenyl ring having a substituent selected         from R¹ at the para (4-) position and optionally up to 2         additional R¹ substituents.     -   Embodiment A7. A compound of Embodiment A1 wherein Q¹ is a 5- to         6-membered fully unsaturated heterocyclic ring optionally         substituted with up to 5 substituents independently selected         from R¹ on carbon atom ring members and selected from R³ on         nitrogen atom ring members.     -   Embodiment A8. A compound of Embodiment A7 wherein Q¹ is a         pyridyl ring optionally substituted with up to 2 R¹.     -   Embodiment A9. A compound of Embodiment A8 wherein Q¹ is a         3-pyridyl ring substituted with R¹ at the position para to the         bond connecting Q¹ to the remainder of the compound of Formula         I.     -   Embodiment A10. A compound of Embodiment A7 wherein Q¹ is a         thiophenyl or furanyl ring optionally substituted with up to 2         R¹.     -   Embodiment A11. A compound of Embodiment A1 wherein Q¹ is an 8-         to 10-membered heteroaromatic bicyclic ring system optionally         substituted with R¹ and R³, the remainder of Formula I is bonded         to a fully unsaturated ring of said bicyclic ring system.     -   Embodiment A12. A compound of Embodiment A1 wherein Q² is a         phenyl ring optionally substituted with up to 5 substituents         independently selected from R⁴.     -   Embodiment A13. A compound of Embodiment A12 wherein Q² is a         phenyl ring substituted with 1 to 4 substituents independently         selected from R⁴.     -   Embodiment A14. A compound of Embodiment A13 wherein Q² is a         phenyl ring substituted with 1 to 3 substituents independently         selected from R⁴.     -   Embodiment A15. A compound of any one of Embodiments A12 through         A14 wherein Q² is a phenyl ring having a substituent selected         from R⁴ at the ortho (2-) position and optionally up to 2         additional R⁴ substituents.     -   Embodiment A16. A compound of Embodiment A1 wherein Q² is a         pyridyl ring optionally substituted with up to 2 R⁴.     -   Embodiment A17. A compound of Embodiment A16 wherein Q² is a         2-pyridyl or 3-pyridyl ring optionally substituted with up to 2         R⁴.     -   Embodiment A18. A compound of Embodiment A1 wherein Q² is a         5-membered fully unsaturated heterocyclic ring optionally         substituted with up to 2 R⁴.     -   Embodiment A19. A compound of Embodiment A18 wherein Q² is a         oxazolyl ring optionally substituted with up to 2 R⁴.     -   Embodiment A20. A compound of any of Embodiments A1 through A19         wherein R is C₁-C₄ alkyl.     -   Embodiment A21. A compound of Embodiment A20 wherein R is methyl         or ethyl.     -   Embodiment A22. A compound of Embodiment A21 wherein R is         methyl.     -   Embodiment A23. A compound of Embodiment A21 wherein R is ethyl.     -   Embodiment A24. A compound of any of Embodiments A1 through A23         wherein R¹ is independently halogen, cyano, nitro, C₁-C₈ alkyl,         C₁-C₈ haloalkyl, C₁-C₈ nitroalkyl, C₂-C₈ alkenyl, C₂-C₈         haloalkenyl, C₂-C₈ haloalkoxyalkoxy, C₂-C₈ nitroalkenyl, C₂-C₈         alkynyl or C₂-C₈ haloalkynyl.     -   Embodiment A25. A compound of Embodiment A24 wherein R¹ is         independently halogen, cyano, nitro, C₁-C₈ alkyl, C₁-C₈         haloalkyl or C₂-C₈ haloalkoxyalkoxy.     -   Embodiment A26. A compound of Embodiment A25 wherein R¹ is         independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl.     -   Embodiment A27. A compound of Embodiment A26 wherein R¹ is         independently halogen or C₁-C₃ haloalkyl.     -   Embodiment A28. A compound of Embodiment A27 wherein R¹ is         independently F or CF₃.     -   Embodiment A29. A compound of Embodiment A28 wherein R¹ is CF₃.     -   Embodiment A30. A compound of Embodiment A28 wherein R¹ is F.     -   Embodiment A31. A compound of any of Embodiments A1 through A30         wherein R³ is independently C₁-C₃ alkyl, C₂-C₃ alkenyl, C₂-C₃         alkynyl, C₃-C₆ cycloalkyl or C₁-C₃ alkoxy.     -   Embodiment A32. A compound of Embodiment A31 wherein R³ is         independently C₁-C₃ alkyl.     -   Embodiment A33. A compound of any of Embodiments A1 through A32         wherein R⁴ is independently halogen, cyano, nitro, C₁-C₈ alkyl,         C₁-C₈ haloalkyl, C₁-C₈ nitroalkyl, C₂-C₈ alkenyl, C₂-C₈         haloalkenyl, C₂-C₈ haloalkoxyalkoxy, C₂-C₈ nitroalkenyl, C₂-C₈         alkynyl or C₂-C₈ haloalkynyl.     -   Embodiment A34. A compound of Embodiment A33 wherein R⁴ is         independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl.     -   Embodiment A35. A compound of Embodiment A34 wherein R⁴ is         independently halogen or C₁-C₃ haloalkyl.     -   Embodiment A36. A compound of Embodiment A35 wherein R⁴ is         independently F or CF₃.     -   Embodiment A37. A compound of Embodiment A36 wherein R⁴ is F.     -   Embodiment A38. A compound of Embodiment A36 wherein R⁴ is CF₃.     -   Embodiment A39. A compound of any one of Embodiments A1 through         A38 wherein the stereochemistry of the carbon center connecting         Q¹ to the remainder of Formula I is S.     -   Embodiment A40. A compound of any one of Embodiments A1 through         A38 wherein the stereochemistry of the carbon center connecting         Q¹ to the remainder of Formula I is R.     -   Embodiment B1. A method for preparing a compound of Formula I as         described in the Summary of Invention.     -   Embodiment B2. A method of Embodiment B1 wherein Q¹ is a phenyl         ring optionally substituted with up to 5 substituents         independently selected from R¹.     -   Embodiment B3. A method of Embodiment B2 wherein Q¹ is a phenyl         ring substituted with 1 to 4 substituents independently selected         from R¹.     -   Embodiment B4. A method of Embodiment B3 wherein Q¹ is a phenyl         ring substituted with 1 to 3 substituents independently selected         from R¹.     -   Embodiment B5. A method of any one of Embodiments B1 through B4         wherein Q¹ is a phenyl ring having a substituent selected from         R¹ at the meta (3-) position and optionally up to 2 additional         R¹ substituents.     -   Embodiment B6. A method of any one of Embodiments B1 through B5         wherein Q¹ is a phenyl ring having a substituent selected from         R¹ at the para (4-) position and optionally up to 2 additional         R¹ substituents.     -   Embodiment B7. A method of Embodiment B1 wherein Q¹ is a 5- to         6-membered fully unsaturated heterocyclic ring optionally         substituted with up to 5 substituents independently selected         from R¹ on carbon atom ring members and selected from R³ on         nitrogen atom ring members.     -   Embodiment B8. A method of Embodiment B7 wherein Q¹ is a pyridyl         ring optionally substituted with up to 2 R¹.     -   Embodiment B9. A method of Embodiment B8 wherein Q¹ is a         3-pyridyl ring substituted with R¹ at the position para to the         bond connecting Q¹ to the remainder of the method of Formula I.     -   Embodiment B10. A method of Embodiment B7 wherein Q¹ is a         thiophenyl or furanyl ring optionally substituted with up to 2         R¹.     -   Embodiment B11. A method of Embodiment B1 wherein Q¹ is an 8- to         10-membered heteroaromatic bicyclic ring system optionally         substituted with R¹ and R³, the remainder of Formula I is bonded         to a fully unsaturated ring of said bicyclic ring system.     -   Embodiment B12. A method of Embodiment B1 wherein Q² is a phenyl         ring optionally substituted with up to 5 substituents         independently selected from R⁴.     -   Embodiment B13. A method of Embodiment B12 wherein Q² is a         phenyl ring substituted with 1 to 4 substituents independently         selected from R⁴.     -   Embodiment B14. A method of Embodiment B13 wherein Q² is a         phenyl ring substituted with 1 to 3 substituents independently         selected from R⁴.     -   Embodiment B15. A method of any one of Embodiments B12 through         B14 wherein Q² is a phenyl ring having a substituent selected         from R⁴ at the ortho (2-) position and optionally up to 2         additional R⁴ substituents.     -   Embodiment B16. A method of Embodiment B1 wherein Q² is a         pyridyl ring optionally substituted with up to 2 R⁴.     -   Embodiment B17. A method of Embodiment B16 wherein Q² is a         2-pyridyl or 3-pyridyl ring optionally substituted with up to 2         R⁴.     -   Embodiment B18. A method of Embodiment B1 wherein Q² is a         5-membered fully unsaturated heterocyclic ring optionally         substituted with up to 2 R⁴.     -   Embodiment B19. A method of Embodiment B18 wherein Q² is a         oxazolyl ring optionally substituted with up to 2 R⁴.     -   Embodiment B20. A method of any of Embodiments B1 through B19         wherein R is C₁-C₄ alkyl.     -   Embodiment B21. A method of Embodiment B20 wherein R is methyl         or ethyl.     -   Embodiment B22. A method of Embodiment B21 wherein R is methyl.     -   Embodiment B23. A method of Embodiment B21 wherein R is ethyl.     -   Embodiment B24. A method of any of Embodiments B1 through B23         wherein R¹ is independently halogen, cyano, nitro, C₁-C₈ alkyl,         C₁-C₈ haloalkyl, C₁-C₈ nitroalkyl, C₂-C₈ alkenyl, C₂-C₈         haloalkenyl, C₂-C₈ haloalkoxyalkoxy, C₂-C₈ nitroalkenyl, C₂-C₈         alkynyl or C₂-C₈ haloalkynyl.     -   Embodiment B25. A method of Embodiment B24 wherein R¹ is         independently halogen, cyano, nitro, C₁-C₈ alkyl, C₁-C₈         haloalkyl or C₂-C₈ haloalkoxyalkoxy.     -   Embodiment B26. A method of Embodiment B25 wherein R¹ is         independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl.     -   Embodiment B27. A method of Embodiment B26 wherein R¹ is         independently halogen or C₁-C₃ haloalkyl.     -   Embodiment B28. A method of Embodiment B27 wherein R¹ is         independently F or CF₃.     -   Embodiment B29. A method of any of Embodiments B7 through B28         wherein R³ is independently C₁-C₃ alkyl, C₂-C₃ alkenyl, C₂-C₃         alkynyl, C₃-C₆ cycloalkyl or C₁-C₃ alkoxy.     -   Embodiment B30. A method of Embodiment B29 wherein R³ is         independently C₁-C₃ alkyl.     -   Embodiment B31. A method of any of Embodiments B1 through B30         wherein R⁴ is independently halogen, cyano, nitro, C₁-C₈ alkyl,         C₁-C₈ haloalkyl, C₁-C₈ nitroalkyl, C₂-C₈ alkenyl, C₂-C₈         haloalkenyl, C₂-C₈ haloalkoxyalkoxy, C₂-C₈ nitroalkenyl, C₂-C₈         alkynyl or C₂-C₈ haloalkynyl.     -   Embodiment B32. A method of Embodiment B31 wherein R⁴ is         independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl.     -   Embodiment B33. A method of Embodiment B32 wherein R⁴ is         independently halogen or C₁-C₃ haloalkyl.     -   Embodiment B34. A method of Embodiment B33 wherein R⁴ is         independently F or CF₃.     -   Embodiment B35. A method of any one of Embodiments B1 through         B34 wherein the stereochemistry of the carbon center connecting         Q¹ to the remainder of Formula I is S.     -   Embodiment B36. A method of any one of Embodiments B1 through         B34 wherein the stereochemistry of the carbon center connecting         Q¹ to the remainder of Formula I is R.     -   Embodiment B37. A method of any one of Embodiments B1 through         B36 wherein a catalyst is present.     -   Embodiment B38. A method of Embodiment B37 wherein the catalyst         is an organometallic complex.     -   Embodiment B39. A method of Embodiment B38 wherein the catalyst         is a nickel complex.     -   Embodiment B40. A method of Embodiment B39 wherein the nickel         complex is chiral.     -   Embodiment B41. A method of Embodiment B40 wherein the nickel         complex is Ni(II) with vicinal diamine ligands.     -   Embodiment B42. A method of Embodiment B41 wherein the ligands         are N substituted cyclohexane-1,2 diamines or         1,1′-Bi(tetrahydroisoquinoline)-diamines.     -   Embodiment B43. A method of Embodiment B42 wherein the nickel         complex is Ni(II)         Bis[(R,R)—N,N′-dibenzylcyclohexane-1,2-diamine]bromide or Ni(II)         Bis[(S,S)—N,N′-dibenzylcyclohexane-1,2-diamine]bromide.     -   Embodiment B44. A method of any one of Embodiments B1 through         B43 wherein a base is present.     -   Embodiment B45. A method of Embodiments B44 wherein the base is         an organic base.     -   Embodiment B46. A method of Embodiments B45 wherein the base is         triethylamine, morpoline or piperidine.     -   Embodiment C1. A method for preparing a compound of Formula IV         as described in the Summary of Invention.     -   Embodiment C2. A method of Embodiment C1 wherein Q¹ is a phenyl         ring optionally substituted with up to 5 substituents         independently selected from R¹.     -   Embodiment C3. A method of Embodiment C2 wherein Q¹ is a phenyl         ring substituted with 1 to 4 substituents independently selected         from R¹.     -   Embodiment C4. A method of Embodiment C3 wherein Q¹ is a phenyl         ring substituted with 1 to 3 substituents independently selected         from R¹.     -   Embodiment C5. A method of any one of Embodiments C1 through C4         wherein Q¹ is a phenyl ring having a substituent selected from         R¹ at the meta (3-) position and optionally up to 2 additional         R¹ substituents.     -   Embodiment C6. A method of any one of Embodiments C1 through C4         wherein Q¹ is a phenyl ring having a substituent selected from         R¹ at the para (4-) position and optionally up to 2 additional         R¹ substituents.     -   Embodiment C7. A method of Embodiment C1 wherein Q¹ is a 5- to         6-membered fully unsaturated heterocyclic ring optionally         substituted with up to 5 substituents independently selected         from R¹ on carbon atom ring members and selected from R³ on         nitrogen atom ring members.     -   Embodiment C8. A method of Embodiment C7 wherein Q¹ is a pyridyl         ring optionally substituted with up to 2 R¹.     -   Embodiment C9. A method of Embodiment C8 wherein Q¹ is a         3-pyridyl ring substituted with R¹ at the position para to the         bond connecting Q¹ to the remainder of Formula IV.     -   Embodiment C10. A method of Embodiment C7 wherein Q¹ is a         thiophene or furan ring optionally substituted with up to 2 R¹.     -   Embodiment C11. A method of Embodiment C1 wherein Q¹ is an 8- to         10-membered heteroaromatic bicyclic ring system optionally         substituted with R¹ and R³, the remainder of Formula I is bonded         to a fully unsaturated ring of said bicyclic ring system.     -   Embodiment C12. A method of Embodiment C1 wherein Q² is a phenyl         ring optionally substituted with up to 5 substituents         independently selected from R⁴.     -   Embodiment C13. A method of Embodiment C12 wherein Q² is a         phenyl ring substituted with 1 to 4 substituents independently         selected from R⁴.     -   Embodiment C14. A method of Embodiment C13 wherein Q² is a         phenyl ring substituted with 1 to 3 substituents independently         selected from R⁴.     -   Embodiment C15. A method of any one of Embodiments C12 through         C14 wherein Q² is a phenyl ring having a substituent selected         from R⁴ at the ortho (2-) position and optionally up to 2         additional R⁴ substituents.     -   Embodiment C16. A method of Embodiment C1 wherein Q² is a         pyridyl ring optionally substituted with up to 2 R⁴.     -   Embodiment C17. A method of Embodiment C16 wherein Q² is a         2-pyridyl or 3-pyridyl ring optionally substituted with up to 2         R⁴.     -   Embodiment C18. A method of Embodiment C1 wherein Q² is a         5-membered fully unsaturated heterocyclic ring optionally         substituted with up to 2 R⁴.     -   Embodiment C19. A method of Embodiment C18 wherein Q² is an         oxazole ring optionally substituted with up to 2 R⁴.     -   Embodiment C20. A method of any of Embodiments C1 through C19         wherein R¹ is independently halogen, cyano, nitro, C₁-C₈ alkyl,         C₁-C₈ haloalkyl, C₁-C₈ nitroalkyl, C₂-C₈ alkenyl, C₂-C₈         haloalkenyl, C₂-C₈ haloalkoxyalkoxy, C₂-C₈ nitroalkenyl, C₂-C₈         alkynyl or C₂-C₈ haloalkynyl.     -   Embodiment C21. A method of Embodiment C20 wherein R¹ is         independently halogen, cyano, nitro, C₁-C₈ alkyl, C₁-C₈         haloalkyl or C₂-C₈ haloalkoxyalkoxy.     -   Embodiment C22. A method of Embodiment C21 wherein R¹ is         independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl.     -   Embodiment C23. A method of Embodiment C22 wherein R¹ is         independently halogen or C₁-C₃ haloalkyl.     -   Embodiment C24. A method of Embodiment C23 wherein R¹ is         independently F or CF₃.     -   Embodiment C25. A method of any of Embodiments C7 through C24         wherein R³ is independently C₁-C₃ alkyl, C₂-C₃ alkenyl, C₂-C₃         alkynyl, C₃-C₆ cycloalkyl or C₁-C₃ alkoxy.     -   Embodiment C26. A method of Embodiment C25 wherein R³ is         independently C₁-C₃ alkyl.     -   Embodiment C27. A method of any of Embodiments C1 through C26         wherein R⁴ is independently halogen, cyano, nitro, C₁-C₈ alkyl,         C₁-C₈ haloalkyl, C₁-C₈ nitroalkyl, C₂-C₈ alkenyl, C₂-C₈         haloalkenyl, C₂-C₈ haloalkoxyalkoxy, C₂-C₈ nitroalkenyl, C₂-C₈         alkynyl or C₂-C₈ haloalkynyl.     -   Embodiment C28. A method of Embodiment C27 wherein R⁴ is         independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl.     -   Embodiment C29. A method of Embodiment C28 wherein R⁴ is         independently halogen or C₁-C₃ haloalkyl.     -   Embodiment C30. A method of Embodiment C29 wherein R⁴ is         independently F or CF₃.     -   Embodiment C31. A method of any one of Embodiments C1 through         C30 wherein the stereochemistry of a compound of Formula IV is         (3R,4S).     -   Embodiment C31a. A method of any one of Embodiments C1 through         C30 wherein the stereochemistry of a compound of Formula IV is         (3S,4R).     -   Embodiment C32. A method of any one of Embodiments C1 through         C31 wherein the reducing agent is hydrogen in the presence of a         catalyst.     -   Embodiment C33. A method of Embodiment C32 wherein the catalyst         is Pd/C.     -   Embodiment C34. A method of any one of Embodiments C1 through         C31 wherein the reducing agent is metal in acid.     -   Embodiment C35. A method of Embodiment C34 wherein the metal is         zinc and the acid is acetic acid.

Embodiments of this invention, including any one of Embodiments A1 through A34, B1 through B41 and C1 through C35 above as well as any other embodiments described herein, can be combined in any manner, and the descriptions of variables in the embodiments pertain not only to the compounds of Formula I and IV but also to the starting compounds and intermediate compounds useful for preparing the compounds of Formula I and IV.

Combinations of Embodiments A1 through A34, B1 through B41 and C1 through C35 are illustrated by:

-   Embodiment AA1. A compound of Formula I wherein     -   Q¹ is a phenyl ring substituted with 1 to 3 substituents         independently selected from R¹;     -   Q² is a phenyl ring substituted with 1 to 3 substituents         independently selected from R⁴;     -   R is C₁-C₄ alkyl;     -   R¹ is independently halogen, cyano, nitro, C₁-C₈ alkyl, C₁-C₈         haloalkyl or C₂-C₈ haloalkoxyalkoxy; and     -   R⁴ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl. -   Embodiment AA2. A compound of Embodiment AA1 wherein     -   Q¹ is a phenyl ring having a substituent selected from R¹ at the         meta (3-) position and optionally up to 2 additional R¹         substituents;     -   Q² is a phenyl ring having a substituent selected from R⁴ at the         ortho (2-) position and optionally up to 2 additional R⁴         substituents;     -   R is methyl or ethyl;     -   R¹ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl; and     -   R⁴ is independently halogen or C₁-C₃ haloalkyl. -   Embodiment AA3. A compound of Embodiment AA1 wherein     -   Q¹ is a phenyl ring having a substituent selected from R¹ at the         para (4-) position and optionally up to 2 additional R¹         substituents;     -   Q² is a phenyl ring having a substituent selected from R⁴ at the         ortho (2-) position and optionally up to 2 additional R⁴         substituents;     -   R is methyl or ethyl;     -   R¹ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl; and     -   R⁴ is independently halogen or C₁-C₃ haloalkyl. -   Embodiment AA4. A compound of Formula I wherein     -   Q¹ is a 5- to 6-membered fully unsaturated heterocyclic ring         optionally substituted with up to 5 substituents independently         selected from R¹ on carbon atom ring members and selected from         R³ on nitrogen atom ring members;     -   Q² is a phenyl ring substituted with 1 to 3 substituents         independently selected from R⁴;     -   R is C₁-C₄ alkyl;     -   R¹ is independently halogen, cyano, nitro, C₁-C₈ alkyl, C₁-C₈         haloalkyl or C₂-C₈ haloalkoxyalkoxy;     -   R³ is independently C₁-C₃ alkyl, C₂-C₃ alkenyl, C₂-C₃ alkynyl,         C₃-C₆ cycloalkyl or C₁-C₃ alkoxy; and     -   R⁴ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl. -   Embodiment AA5. A compound of Embodiment AA4 wherein     -   Q¹ is a pyridyl ring optionally substituted with up to 2 R¹;     -   Q² is a phenyl ring substituted with 1 to 2 substituents         independently selected from R⁴;     -   R is methyl or ethyl;     -   R¹ is independently halogen or C₁-C₃ haloalkyl; and     -   R⁴ is independently halogen or C₁-C₃ haloalkyl. -   Embodiment AA6. A compound of AA4 wherein     -   Q¹ is a 3-pyridyl ring substituted with R¹ at the position para         to the bond connecting Q¹ to the remainder of the compound of         Formula I; or Q¹ is a thiophene or furan ring optionally         substituted with up to 2 R¹;     -   Q² is a phenyl ring substituted with 1 to 2 substituents         independently selected from R⁴;     -   R is methyl or ethyl;     -   R¹ is independently halogen or C₁-C₃ haloalkyl; and     -   R⁴ is independently halogen or C₁-C₃ haloalkyl. -   Embodiment AA7. A compound of Formula I wherein     -   Q² is a 2-pyridyl or 3-pyridyl ring optionally substituted with         up to 2 R⁴;     -   R is methyl or ethyl;     -   R¹ is independently halogen or C₁-C₃ haloalkyl; and     -   R⁴ is independently halogen or C₁-C₃ haloalkyl. -   Embodiment AA8. A compound of Formula I wherein     -   Q² is a oxazolyl ring optionally substituted with up to 2 R⁴;     -   R is methyl or ethyl;     -   R¹ is independently halogen or C₁-C₃ haloalkyl; and     -   R⁴ is independently halogen or C₁-C₃ haloalkyl. -   Embodiment AA9. A compound of any one of Embodiments AA1 through AA8     wherein the stereochemistry of the carbon center connecting Q¹ to     the remainder of Formula I is S or R. -   Embodiment BB1. A method for preparing a compound of Formula I as     described in the Summary of the Invention wherein     -   Q¹ is a phenyl ring substituted with 1 to 3 substituents         independently selected from R¹;     -   Q² is a phenyl ring substituted with 1 to 3 substituents         independently selected from R⁴;     -   R is C₁-C₄ alkyl;     -   R¹ is independently halogen, cyano, nitro, C₁-C₈ alkyl, C₁-C₈         haloalkyl or C₂-C₈ haloalkoxyalkoxy; and     -   R⁴ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl. -   Embodiment BB2. A method of Embodiment BB1 wherein     -   Q¹ is a phenyl ring having a substituent selected from R¹ at the         meta (3-) position and optionally up to 2 additional R¹         substituents;     -   Q² is a phenyl ring having a substituent selected from R⁴ at the         ortho (2-) position and optionally up to 2 additional R⁴         substituents;     -   R is methyl or ethyl;     -   R¹ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl;     -   R⁴ is independently halogen or C₁-C₃ haloalkyl; -   Embodiment BB3. A method of any one of Embodiments BB1 and BB2     wherein     -   the catalyst is a nickel complex; and     -   the base is an organic base. -   Embodiment BB4. A method of Embodiment BB3 wherein     -   the nickel complex is Ni(II) with chiral vicinal diamine         ligands. -   Embodiment BB5. A method of Embodiment BB4 wherein     -   the ligands are N substituted cyclohexane-1,2 diamines or         1,1′-Bi(tetrahydroisoquinoline)-diamines; and     -   the base is triethylamine, morpoline or piperidine. -   Embodiment BB6. A method of any one of Embodiments BB1 through BB5     wherein the stereochemistry of the carbon center connecting Q¹ to     the remainder of Formula I is S or R. -   Embodiment CC1. A method for preparing a compound of Formula IV as     described in the Summary of Invention wherein     -   Q¹ is a phenyl ring substituted with 1 to 3 substituents         independently selected from R¹;     -   Q² is a phenyl ring substituted with 1 to 3 substituents         independently selected from R⁴;     -   R is C₁-C₄ alkyl;     -   R¹ is independently halogen, cyano, nitro, C₁-C₈ alkyl, C₁-C₈         haloalkyl or C₂-C₈ haloalkoxyalkoxy; and     -   R⁴ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl. -   Embodiment CC2. A method of Embodiment CC1 wherein     -   Q¹ is a phenyl ring having a substituent selected from R¹ at the         meta (3-) position and optionally up to 2 additional R¹         substituents;     -   Q² is a phenyl ring having a substituent selected from R⁴ at the         ortho (2-) position and optionally up to 2 additional R⁴         substituents;     -   R¹ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl;     -   R⁴ is independently halogen or C₁-C₃ haloalkyl; and -   Embodiment CC3. A method for preparing a compound of Formula IV as     described in the Summary of Invention wherein     -   Q¹ is a pyridyl ring optionally substituted with up to 2 R¹;     -   Q² is a phenyl ring substituted 1 to 3 substituents         independently selected from R⁴;     -   R¹ is independently halogen or C₁-C₃ haloalkyl; and     -   R⁴ is independently halogen or C₁-C₃ haloalkyl. -   Embodiment CC4. A method of any one of Embodiments CC1 through CC3     wherein the stereochemistry of a compound of Formula IV is (3R,4S)     or (3S,4R). -   Embodiment CC5. A method of any one of Embodiments CC1 through CC4     wherein the reducing agent is hydrogen in the presence of a catalyst     or metal in acid.

Specific embodiments include compounds of Formula I selected from the group consisting of:

-   Ethyl     (βS)-α-[[(2-fluorophenyl)amino]carbonyl]-β-(nitromethyl)-3-(trifluoromethyl)benzenepropanoate; -   Ethyl     α-[[(2-fluorophenyl)amino]carbonyl]-β-(nitromethyl)-3-(trifluoromethyl)benzenepropanoate; -   (3R,4S)—N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide;     and -   rel-(3R,4S)—N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide.

The pyrrolidinones of Formula IV are useful as herbicides as disclosed in PCT/US14/68073.

The compounds of Formula I and IV can be prepared by general methods known in the art of synthetic organic chemistry. One or more of the following methods and variations as described in Schemes 1-5 can be used to prepare the compounds of Formula I and IV. The definitions of Q¹, Q², R in the compounds of Formulae I, II, III, IV, a, b, c, d, e and f below are as defined above in the Summary of the Invention unless otherwise noted. All substituents for Formulae a, b, c, d, e and f are as defined above for Formulae I, II, III and IV unless otherwise noted.

As shown in Scheme 1, a compound of Formula IV can be obtained by the reduction of a compound of Formula I and subsequent in situ cyclization of the resulting intermediate amine. A wide variety of methods for reduction of the aliphatic nitro group in compounds of Formula I are known in the literature. Methods well known to those skilled in the art include catalytic hydrogenation in the presence of palladium on carbon, reduction using Raney nickel, iron or zinc metal in acidic medium (see, for example, Berichte der Deutschen Chemischen Gesellschaft 1904, 37, 3520-3525) and reduction using lithium aluminum hydride. Reduction can also be achieved with samarium(II) iodide in the presence of a proton source such as methanol (see for example, Tetrahedron Letters 1991, 32 (14), 1699-1702). Alternatively sodium borohydride in the presence of a nickel catalyst such as nickel(II) acetate or nickel(II) chloride can be used (see for example, Tetrahedron Letters 1985, 26 (52), 6413-6416). The method of utilizing sodium borohydride in the presence of nickel(II) chloride is illustrated by Step C of Synthesis Example 1.

As shown in Scheme 2, a compound of Formula I can be prepared by reacting compounds of Formula a with nitromethane in the presence of a base. Suitable bases for the reaction include alkali metal lower alkoxides such as sodium methoxide in methanol or sodium ethoxide in ethanol.

Alternatively, as shown in Scheme 3, a compound of Formula I can be prepared by reacting nitroalkenes of Formula II with malonates of Formula III in the presence of a catalyst, a base or both a catalyst and a base. Suitable catalysts for this reaction include, but are not limited to, a Ni(II) complex with vicinal diamine ligrands such as Ni(II) Bis[(R,R)—N,N′-dibenzylcyclohexane-1,2-diamine]bromide or Ni(II)Br₂ complexed with chiral 1,1′-Bi(tetrahydroisoquinoline)-diamines. Suitable bases for this reaction include, but are not limited to, alkali metal lower alkoxides such as sodium methoxide in methanol or sodium ethoxide in ethanol, organic bases such as piperidine, morpholine, triethyl amine, N-methyl morpholine or N, N-diisopropylehtyl amine, or bases such as lithium bis(trimethylsilyl)amide, sodium bis(trimethylsilyl)amide and lithium diisopropylamide in solvents such as tetrahydrofuran, toluene or dichloromethane. Typically, the reaction is carried out at a temperature from about −78° C. to about 23° C. optionally in the presence of 0 to 2 equivalents of catalyst or/and base. See Synthesis 2005, 2239-2245 for conditions for effecting this transformation and see J. Am. Chem. Soc. 2005, 9958-9959 or Eur. J. Org. Chem. 2011, 5441-5446 for conditions to accomplish this transformation stereoselectively. Conditions for effecting this transformation in refluxing water in the absence of catalyst have been reported in Synthetic Communications 2013, 43, 744-748. Nitroalkenes of Formula II can readily be prepared from aldehydes and nitromethane by methods known to those skilled in the art.

As shown in Scheme 4, compounds of Formula a can be prepared by reaction of malonates of Formula d with aldehydes of Formula e by methods known to those skilled in the art, e.g., by Knoevenagel condensation of aldehydes and malonates (see for example, Jones, G., Organic Reactions; Volume 15, John Wiley & Sons, 1967). As also shown in Scheme 4, malonates of Formula d can readily be prepared from lower alkyl malonyl chlorides of Formula b such as methyl malonyl chloride and amines of Formula c by methods known to those skilled in the art.

As shown in Scheme 5, compounds of Formula II can be prepared by reaction of nitromethane with an aldehyde of Formula e in the presence of a base. Dehydration of the intermediate f may be accomplished by azeotropic distillation of water from the reaction mixture or reacting with methanesulfonyl chloride in the presence of a base such as triethylamine. Suitable bases for this reaction include, but are not limited to, alkali metal lower alkoxides such as sodium hydroxide, sodium methoxide in methanol or sodium ethoxide in ethanol, ammonium acetate; or organic bases such as piperidine, morpholine or triethyl amine in solvents such as methanol, toluene, acetic acid or 1-chlorobutane. Typically, the reaction is carried out at a temperature from about −78° C. to 130° C. in the presence of 0 to 2 equivalents of catalyst or base. For representative conditions to prepare nitrostyrenes, see WO 2012/158413, US2011/207944 and WO2004/18455.

It is recognized by one skilled in the art that various functional groups can be converted into others to provide different compounds of Formula I. For a valuable resource that illustrates the interconversion of functional groups in a simple and straightforward fashion, see Larock, R. C., Comprehensive Organic Transformations: A Guide to Functional Group Preparations, 2nd Ed., Wiley-VCH, New York, 1999. For example, intermediates for the preparation of compounds of Formula I may contain aromatic nitro groups, which can be reduced to amino groups, and then be converted via reactions well known in the art such as the Sandmeyer reaction, to various halides, providing compounds of Formula I. The above reactions can also in many cases be performed in alternate order

It is recognized that some reagents and reaction conditions described above for preparing compounds of Formula I may not be compatible with certain functionalities present in the intermediates. In these instances, the incorporation of protection/deprotection sequences or functional group interconversions into the synthesis will aid in obtaining the desired products. The use and choice of the protecting groups will be apparent to one skilled in chemical synthesis (see, for example, Greene, T. W.; Wuts, P. G. M. Protective Groups in Organic Synthesis, 2nd ed.; Wiley: New York, 1991). One skilled in the art will recognize that, in some cases, after the introduction of a given reagent as it is depicted in any individual scheme, it may be necessary to perform additional routine synthetic steps not described in detail to complete the synthesis of compounds of Formula I. One skilled in the art will also recognize that it may be necessary to perform a combination of the steps illustrated in the above schemes in an order other than that implied by the particular presented to prepare the compounds of Formula I.

One skilled in the art will also recognize that compounds of Formula I and the intermediates described herein can be subjected to various electrophilic, nucleophilic, radical, organometallic, oxidation, and reduction reactions to add substituents or modify existing substituents.

Without further elaboration, it is believed that one skilled in the art using the preceding description can utilize the present invention to its fullest extent. The following Examples are, therefore, to be construed as merely illustrative, and not limiting of the disclosure in any way whatsoever. Steps in the following Examples illustrate a procedure for each step in an overall synthetic transformation, and the starting material for each step may not have necessarily been prepared by a particular preparative run whose procedure is described in other Examples or Steps. Percentages are by weight except for chromatographic solvent mixtures or where otherwise indicated. Parts and percentages for chromatographic solvent mixtures are by volume unless otherwise indicated. ¹H NMR spectra are reported in ppm downfield from tetramethylsilane in CDCl₃ solution unless indicated otherwise; “s” means singlet, “d” means doublet, “t” means triplet, “q” means quartet, “m” means multiplet and “br s” means broad singlet. ¹⁹F NMR spectra are reported in ppm downfield from CFCl₃ in CDCl₃ unluess indicated otherwise. The enentiomeric ratio (ER) was determined by chiral high performance liquid chromatography analysis using a Chiralpak AD-RH column and eluting with a 50:50 isopropanol/water mixture at 40° C. at 0.3 mL/min.

Synthesis Example 1 Preparation of rel-(3R,4S)—N-(2-Fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide Step A: Preparation of 1-[(E)-2-nitroethenyl]-3-(trifluoromethyl)benzene

To a stirred solution of 3-(trifluoromethyl)benzaldehyde (12.2 g, 70.1 mmol) in methanol (50 mL) was added nitromethane (4.34 g, 71.1 mmol). The mixture was cooled to 2° C. and sodium hydroxide (5.65 g, 70.6 mmol) was added as a 50% solution in 24.3 mL of water dropwise over 15 min. An exotherm was noted and additional ice was added to maintain the internal temperature below 10° C. while stirring for an additional 1 h. The reaction mixture was poured into 75 mL of 1 N hydrochloric acid, rinsing the flask with 10 mL of methanol/water. The quenched reaction mixture was transferred to a separatory funnel and extracted with 150 mL of toluene. The aqueous layer was separated and the organic layer was concentrated under vacuum to yield 15.84 g of a yellow oil.

The yellow oil (15.84 g, 67.3 mmol) thus obtained was taken up in 160 mL of dichloromethane. The solution was cooled to 3° C. and methanesulfonyl chloride (8.03 g, 71.1 mmol) was added via pipette as a solution in 50 mL of dichloromethane. A solution of triethylamine (14.2 g, 140 mmol) in 50 ml of dichloromethane was then added dropwise over 50 min. The mixture was stirred for 2 h and then poured into 150 mL of 1 N hydrochloric acid and transferred to a separatory funnel. The layers were separated and the organic layer was washed with 150 mL water and then filtered. The organic layer was concentrated under reduced pressure and the crude solid was triturated with hexanes to yield 12.09 g (79.4% yield over two steps) of product as a yellow solid.

¹H NMR (500 MHz) δ 7.96-8.08 (m, 1H), 7.69-7.84 (m, 3H), 7.54-7.66 (m, 2H).

Step B: Preparation of ethyl 3-[(2-fluorophenyl)amino]-3-oxopropanote

To a stirred solution of 2-fluoroaniline (10 g, 90.0 mmol) and triethylamine (9.1 g, 90.0 mmol) in dichloromethane (50 mL) at 0° C. was added dropwise over 10 minutes a solution of ethyl malonyl chloride (15.5 g, 90.0 mmol) in dichloromethane (30 mL). The resulting mixture was stirred at room temperature for 24 h. The reaction mixture was then poured into water (100 mL), and the organic layer was separated, washed with water (50 mL) and brine (50 mL), dried (MgSO₄) and concentrated under reduced pressure to provide the title compound as an amber oil (19.0 g).

¹H NMR δ 9.46 (br s, 1H), 8.28 (m, 1H), 7.10 (m, 2H), 4.26 (m, 2H), 3.51 (s, 2H), 1.32 (t, 3H).

Step C: Preparation of Ethyl α-[[(2-fluorophenyl)amino]carbonyl]-β-(nitromethyl)-3-(trifluoromethyl)benzenepropanoate

A stirred solution of 1-[(E)-2-nitrovinyl]-3-(trifluoromethyl)benzene (i.e. the product of Step A, 12 g, 55 mmol) and ethyl 3-[(2-fluorophenyl)amino]-3-oxopropanote (i.e. the product of Step B, 12.4 g, 55 mmol) in anhydrous tetrahydrofuran (55 mL) was cooled to −5° C. under an atmosphere of nitrogen. To this mixture was added triethylamine (7.7 mL, 55 mmol) as a solution in anhydrous tetrahydrofuran (15 mL) over the course of 10 min. The reaction was stirred and allowed to warm to ambient temperature over the course of 1.5 h. The solution was concentrated under reduced pressure. The resulting crude solid was triturated with Et₂O, filtered and washed with a small amount of Et₂O and then hexanes. After drying with suction under nitrogen, 16.25 g of a white solid was isolated. Concentration of the filtrate and trituration with 1-chlorobutane at 50° C. yielded 3.45 g of additional product (NMR data is a 1:1 mixture of two diastereomers).

¹H NMR (500 MHz, DMSO-d₆) δ 10.16 (s, 1H), 10.03 (s, 1H), 7.44-7.88 (m, 8H), 6.85-7.33 (m, 8H), 4.95-5.16 (m, 4H), 4.10-4.38 (m, 6H), 3.84-4.01 (m, 2H), 1.17-1.24 (m, 3H), 0.90-1.00 (m, 3H); ¹⁹F NMR (471 MHz, DMSO-d₆) δ−124.41-−124.17 (m, 2F), −61.56-−60.99 (m, 6F).

Step D: Preparation of rel-(3R,4S)—N-(2-Fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide

To a solution of Ethyl α-[[(2-fluorophenyl)amino]carbonyl]-β-(nitromethyl)-3-(trifluoromethyl)benzenepropanoate (i.e. the product of Step C, 15.1 g, 34 mmol) in anhydrous N,N-dimethyformamide (30 mL) and methanol (160 mL) was added NiCl₂.6H₂O dust (8.1 g, 34 mmol) in one portion. After the solution became clear the mixture was cooled to −7° C. NaBH₄ (3.8 g, 100 mmol) was added in 0.5 g portions maintaining the internal temperature below 0° C. The reaction mixture was warmed to ambient temperature with stirring overnight. The solution was concentrated under reduced pressure and the crude material was suspended in dichloromethane (300 ml) and adsorbed onto of mixture of silica gel (60 g) and celite (25 g). Following concentration in vacuo, the sample was filtered through a plug of silica gel (160 g), eluting with ethyl acetate until no more product came through the plug. Concentration under reduced pressure gave 9.55 g of the desired product as an oily, off white solid. ¹H NMR (500 MHz) δ 9.70 (br s, 1H), 8.15-8.25 (m, 1H), 7.42-7.68 (m, 4H), 6.97-7.12 (m, 3H), 6.49 (br s, 1H), 4.23-4.34 (m, 1H), 3.81-3.89 (m, 1H), 3.56-3.67 (m, 1H), 3.41-3.53 (m, 1H);

¹⁹F NMR (471 MHz) δ ppm −129.69-−129.51 (m, 1F), −62.56 (s, 3F).

Synthesis Example 2 Preparation of (3R,4S)—N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide Step A: Preparation of Ethyl (βS)-α-[[(2-fluorophenyl)amino]carbonyl]-β-(nitromethyl)-3-(trifluoromethyl)benzenepropanoate

To a mechanically stirred solution of 1-[(E)-2-nitroethenyl]-3-(trifluoromethyl)benzene (i.e. the product of Step A in Synthesis Example 1, 70 g, 0.32 mol) and ethyl 3-[(2-fluorophenyl)amino]-3-oxopropanote (i.e. the product of Step B in Synthesis Example 1, 72.6 g, 0.3225 mol) in toluene (350 mL) was added Ni(II)-Bis[(R,R)—N,N′-dibenzylcyclohexane-1,2-diamine]bromide (3.9 g, 0.0048 mol). The resulting mixture was stirred for 48 h at ambient temperature. The solution was then diluted with dichloromethane (500 mL) and adsorbed onto silica gel and purified by chromatography (70/30 petroleum ether/ethyl acetate). After standing at ambient temperature, 130 g of a white solid was obtained. Analysis by chiral HPLC (Chiral Pak IA (250×4.6) mm 5μ, 0.1% diethylamine in hexane:ethanol (90:10) at 1.0 mL/min) showed an ER of 89:10.

¹H NMR (500 MHz) δ 8.66 (br s, 2H), 8.16-8.25 (m, 1H), 7.99-8.09 (m, 1H), 7.52-7.62 (m, 3H), 7.39-7.51 (m, 5H), 7.01-7.20 (m, 6H), 5.04-5.09 (m, 2H), 4.87-5.01 (m, 2H), 4.39-4.46 (m, 1H), 4.30 (q, J=7.15 Hz, 3H), 4.02 (q, J=7.20 Hz, 2H), 3.82-3.91 (m, 2H), 1.28-1.37 (m, 3H), 0.93-1.05 (m, 3H);

¹⁹F NMR (471 MHz) δ−130.24-−130.09 (m, 1F), −129.92-−129.76 (m, 1F), −62.84 (s, 3F), −62.80 (s, 3F); NMR data is a 1:1 mixture of two diastereomers.

MP: 130.6-134.6° C.: ESI [M+1] 443.6.

Step B: Preparation of (3R,4S)—N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide

To a solution of Ethyl (βS)-α-[[(2-fluorophenyl)amino]carbonyl]-β-(nitromethyl)-3-(trifluoromethyl)benzenepropanoate (i.e. the product of Step C, 100 g, 0.226 mol) in ethanol (1000 mL) was added zinc dust (144.7 g, 2.26 mol) in one portion. The reaction mixture was heated to 80° C. Acetic acid (108 g, 1.81 mol) was added dropwise over a period of 45 min. After the addition of acetic acid, the solution was heated to 90° C. and stirred for 3 h. The solution was cooled to ambient temperature and diluted with ethyl acetate (1 L) and filtered through a bed of Celite® diatomaceous earth filter aid. The filtrate was concentrated under reduced pressure and the residue was taken up in ethyl acetate (2 L). The organic layer was washed with 0.5 N HCl, water and brine and then dried over Na₂SO₄, filtered and concentrated in vacuo. The thick liquid obtained was triturated with 500 mL of 10% methyl tert-butyl ether/petroleum ether to give a white solid. Filtration and drying provided the title compound as an white solid (56 g, 67% yield). Analysis by chiral HPLC (Chiral Pak IA (250×4.6) mm 5μ, 0.1% DEA in hexane:ethanol (90:10) at 1.0 mL/min) showed an ER of 86:14.

¹H NMR (500 MHz, Acetone-d6) δ 10.05 (br s, 1H), 8.24-8.33 (m, 1H), 7.78-7.90 (m, 2H), 7.57-7.65 (m, 2H), 7.52 (br s, 1H), 7.00-7.22 (m, 3H), 4.20-4.29 (m, 1H), 3.96-4.02 (m, 1H), 3.83-3.92 (m, 1H), 3.41-3.53 (m, 1H);

¹⁹F NMR (471 MHz, Acetone-d6) δ ppm −131.19-−131.01 (m, 1F), −62.93 (s, 3F); MP 141.8-144.7° C.; ESI [M+1] 367.0.

By the procedures described herein together with methods known in the art, the following compounds of Tables 1 to 688 can be prepared. The following abbreviations are used in the Tables which follow: t means tertiary, n means normal, i means iso, c means cyclo, Me means methyl, Et means ethyl, Pr means propyl, Bu means butyl, i-Pr means isopropyl, Bu means butyl, c-Pr cyclopropyl, c-Bu means cyclobutyl, Ph means phenyl, OMe means methoxy, OEt means ethoxy, SMe means methylthio, SEt means ethylthio, NHMe methylamino, —CN means cyano, —NO₂ means nitro, TMS means trimethylsilyl, S(O)Me means methylsulfinyl, and S(O)₂Me means methylsulfonyl.

TABLE 1

R is Me; Q² is Ph(2-F) and Q¹ is Q¹ Q¹ Q¹ Ph(2-Cl) Ph(2-OCO₂Me) Ph(2-CH₂CH═CCl₂) Ph(2-F) Ph(2-TMS) Ph(2-CH₂CH═CBr₂) Ph(2-Br) Ph(2-Ph) Ph(2-OCH₂CH═CH₂) Ph(2-I) Ph[2-(1H-pyrazol-1-yl] Ph(2-OCH₂CH═CF₂) Ph(2-Me) Ph[2-(2H-1,2,3-triazol-2-yl)] Ph(2-OCH₂CH═CCl₂) Ph(2-Et) Ph[2-(1H-imidazol-1-yl)] Ph(2-OCH₂CH═CBr₂) Ph(2-n-Pr) Ph[2-(3-pyridinyl)] Ph(2-SCF₂H) Ph(2-t-Bu) Ph[2-(4-pyridinyl)] Ph(2-SCF₂CF₂H) Ph(2-i-Pr) Ph[2-(2-pyridinyl)] Ph(3-Cl) Ph(2-c-Pr) Ph(2-CF₂CF₃) Ph(3-F) Ph(2-cyclohexyl) Ph(2-CF₂CF₂H) Ph(3-Br) Ph(2-CH═CH₂) Ph(2-OCF₂CF₂H) Ph(3-I) Ph(2-CF₃) Ph(2-OCF₂CF₃) Ph(3-Me) Ph(2-CH₂CF₃) Ph(2-OCH₂CF₃) Ph(3-Et) Ph(2-CF₂H) Ph(2-OCH₂C≡CH) Ph(3-n-Pr) Ph(2-CH₂F) Ph(2-OCH₂C≡CCF₃) Ph(3-t-Bu) Ph(2-OCF₃) Ph(2-OCH₂C≡CCF₂H) Ph(3-i-Pr) Ph(2-OCH₂F) Ph(2-OCH₂C≡CCH₃) Ph(3-c-Pr) Ph(2-OCF₂H) Ph(2-OCH₂C≡C-C-Pr) Ph(3-cyclohexyl) Ph(2-SCF₃) Ph(2-C≡CCF₂H) Ph(3-CH≡CH₂₎ Ph(2-SMe) Ph(2-C≡CCH₃) Ph(3-CF₃) Ph(2-SOMe) Ph(2-C≡CCF₃) Ph(3-CH₂CF₃) Ph(2-SO₂Me) Ph(2-OPh) Ph(3-CF₂H) Ph(2-OSO₂Me) Ph(2-C≡CCF₃) Ph(3-CH₂F) Ph(2-C≡CH) Ph(2-C≡CCF₂H) Ph(3-OCF₃) Ph(2-OMe) Ph(2-C≡CCH₃) Ph(3-OCH₂F) Ph(2-OEt) Ph(2-C≡C-C-Pr) Ph(3-OCF₂H) Ph(2-NHCO₂-t-Bu) Ph(2-CH═CF₂) Ph(3-SCF₃) Ph(2-NHCOMe) Ph(2-CH═CCl₂) Ph(3-SMe) Ph(2-NHCOCF₃) Ph(2-CH═CBr₂) Ph(3-SOMe) Ph(2-CN) Ph(2-OCH═CH₂) Ph(3-SO₂Me) Ph(2-NO₂) Ph(2-OCH═CF₂) Ph(3-OSO₂Me) Ph(2-Ph) Ph(2-OCH═CF₂) Ph(3-CCH) Ph(2-COMe) Ph(2-OCH═CBr₂) Ph(3-OMe) Ph(2-OCOMe) Ph(2-CH₂CH═CH₂) Ph(3-OEt) Ph(2-CO₂Me) Ph(2-CH₂CH═CF₂) Ph(3-NHCO₂-t-Bu) Ph(3-NHCOMe) Ph(3-CH═CF₂) Ph(2-Cl,3-OCF₂H) Ph(3-NHCOCF₃) Ph(3-CH═CCl₂) Ph(2-Cl, 3-SCF₃) Ph(3-CN) Ph(3-CH═CBr₂) Ph(2-Cl,3-SMe) Ph(3-NO₂) Ph(3-OCH═CH₂) Ph(2-Cl,3-SOMe) Ph(3-Ph) Ph(3-OCH═CF₂) Ph(2-C1,3-SO₂Me) Ph(3-COMe) Ph(3-OCH═CCl₂) Ph(2-Cl,3-OSO₂Me) Ph(3-OCOMe) Ph(3-OCH═CBr₂) Ph(2-Cl,3-CCH) Ph(3-CO₂Me) Ph(3-CH₂CH═CH₂) Ph(2-Cl,3-OMe) Ph(3-OCO₂Me) Ph(3-CH₂CH═CF₂) Ph(2-Cl,3-OEt) Ph(3-TMS) Ph(3-CH₂CH═CCl₂) Ph(2-Cl,3-NHCO₂-t-Bu) Ph(3-Ph) Ph(3-CH₂CH═CBr₂) Ph(2-Cl,3-NHCOMe) Ph[3-(1H-pyrazol-1-yl] Ph(3-OCH₂CH═CH₂) Ph(2-Cl,3-NHCOCF₃) Ph[3-(2H-1,2,3-triazol-2-yl] Ph(3-OCH₂CH═CF₂) Ph(2-Cl,3-CN) Ph[3-(1H-imidazol-1-yl] Ph(3-OCH₂CH═CCl₂) Ph(2-Cl,3-NO₂) Ph[3-(3-pyridinyl] Ph(3-OCH₂CH═CBr₂) Ph(2-Cl,3-Ph) Ph[3-(4-pyridinyl] Ph(3-SCF₂H) Ph(2-Cl,3-COMe) Ph[3-(2-pyridinyl] Ph(3-SCF₂CF₂H) Ph(2-Cl,3-OCOMe) Ph(3-CF₂CF₃) Ph(2-Cl,3-Cl) Ph(2-Cl,3-CO₂Me) Ph(3-CF₂CF₂H) Ph(2-Cl,3-F) Ph(2-C1,3-OCO₂Me) Ph(3-OCF₂CF₂H) Ph(2-Cl,3-Br) Ph(2-Cl,3-TMS) Ph(3-OCF₂CF₃) Ph(2-Cl,3-I) Ph(2-Cl,3-Ph) Ph(3-OCH₂CF₃) Ph(2-Cl,3-Me) Ph(3-OCH₂C≡CH) Ph(2-Cl,3-Et) Ph(3-OCH₂C≡CCF₃) Ph(2-Cl,3-n-Pr) Ph[3-(2-Cl,1H-imidazol-1-yl] Ph(3-OCH₂C≡CCF₂H) Ph(2-Cl,3-t-Bu) Ph[3-(2-Cl,3-pyridinyl)] Ph(3-OCH₂C≡CCH₃) Ph(2-Cl,3-i-Pr) Ph[3-(2-Cl,4-pyridinyl)] Ph(3-OCH₂C≡C-c-Pr) Ph(2-Cl,3-c-Pr) Ph[3-(2-Cl,2-pyridinyl)] Ph(3-C≡CCF₂H) Ph(2-Cl,3-cyclohexyl) Ph(2-Cl,3-CF₂CF₃) Ph(3-C≡CCH₃) Ph(2-Cl,3-CH≡CH₂) Ph(2-Cl,3-CF₂CF₂H) Ph(3-C≡C-c-Pr) Ph(2-Cl,3-CF₃) Ph(2-Cl,3-OCF₂CF₂H) Ph(3-OPh) Ph(2-Cl,3-CH₂CF₃) Ph(2-Cl,3-OCF₂CF₃) Ph(3-C≡CCF₃) Ph(2-Cl,3-CF₂H) Ph(2-Cl,3-OCH₂CF₃) Ph(3-C≡CCF₂H) Ph(2-Cl,3-CH₂F) Ph(2-Cl,3-OCH₂C≡CH) Ph(3-C≡CCH₃) Ph(2-Cl,3-OCF₃) Ph(2-Cl,3-OCH₂C≡CCF₃) Ph(3-C≡C-c-Pr) Ph(2-Cl, 3-OCH₂F) Ph(2-Cl,3-OCH₂C≡CCF₂H) Ph(2-Cl,3-OCH₂C≡CCH₃) Ph(2-F,3-i-Pr) Ph[3-(2-F,4-pyridinyl)] Ph(2-Cl,3-OCH₂C≡C-c-Pr) Ph(2-F,3-c-Pr) Ph[3-(2-F,2-pyridinyl)] Ph(2-Cl,3-C≡CCF₂H) Ph(2-F,3-cyclohexyl) Ph(2-F,3-CF₂CF₃) Ph(2-Cl,3-C≡CCH₃) Ph(2-F,3-CH═CH₂) Ph(2-F,3-OCF₂CF₂H) Ph(2-Cl,3-C≡C-c-Pr) Ph(2-F,3-CF₃) Ph(2-F,3-OCF₂CF₂H) Ph(2-Cl,3-OPh) Ph(2-F,3-CH₂CF₃) Ph(2-F,3-OCF₂CF₃) Ph(2-Cl,3-C≡CCF₃) Ph(2-F,3-CF₂H) Ph(2-F,3-OCH₂CF₃) Ph(2-Cl,3-C≡CCF₂H) Ph(2-F,3-CH₂F) Ph(2-F,3-OCH₂C≡CH) Ph(2-Cl,3-C≡CCH₃) Ph(2-F,3-OCF₃) Ph(2-F,3-OCH₂C≡CCF₃) Ph(2-Cl,3-C≡C-c-Pr) Ph(2-F,3-OCH₂F) Ph(2-F,3-OCH₂C≡CCF₂H) Ph(2-Cl,3-CH═CF₂) Ph(2-F,3-OCF₂H) Ph(2-F,3-OCH₂C≡CCH₃) Ph(2-Cl,3-CH═CCl₂) Ph(2-F,3-SCF₃) Ph(2-F,3-OCH₂C≡C-c-Pr) Ph(2-Cl,3-CH═CBr₂) Ph(2-F,3-SMe) Ph(2-F,3-C≡CCF₂H) Ph(2-Cl,3-OCH═CH₂) Ph(2-F,3-SOMe) Ph(2-F,3-C≡CCH₃) Ph(2-Cl,3-OCH═CF₂) Ph(2-F,3-SO₂Me) Ph(2-F,3-C≡C-c-Pr) Ph(2-Cl,3-CH₂CH═CCl₂) Ph(2-F,3-OSO₂Me) Ph(2-F,3-OPh) Ph(2-Cl,3-CH₂CH═CBr₂) Ph(2-F,3-C≡CH) Ph(2-F,3-C≡CCF₃) Ph(2-Cl,3-OCH₂CH═CH₂) Ph(2-F,3-OMe) Ph(2-F,3-C≡CCF₂H) Ph(2-Cl,3-OCH₂CH═CF₂) Ph(2-F,3-OEt) Ph(2-F,3-C≡CCH₃) Ph(2-Cl,3-OCH₂CH═CCl₂) Ph(2-F,3-NHCO₂-t-Bu) Ph(2-F,3-C≡C-c-Pr) Ph(2-Cl,3-CH₂CH═CBr₂) Ph(2-F,3-NHCOMe) Ph(2-F,3-CH═CF₂) Ph(2-Cl,3-OCH₂CH═CH₂) Ph(2-F,3-NHCOCF₃) Ph(2-F,3-CH═CCl₂) Ph(2-Cl,3-OCH₂CH═CF₂) Ph(2-F,3-CN) Ph(2-F,3-CH═CBr₂) Ph(2-Cl,3-OCH₂CH═CCl₂) Ph(2-F,3-NO₂) Ph(2-F,3-CH₂CH═CH₂) Ph(2-Cl,3-OCH₂CH═CBr₂) Ph(2-F,3-Ph) Ph(2-F,3-OCH═CF₂) Ph(2-Cl,3-SCF₂H) Ph(2-F,3-COMe) Ph(2-F,3-CH₂CH═CCl₂) Ph(2-Cl,3-SCF₂CF₂H) Ph(2-F,3-OCOMe) Ph(2-F,3-CH₂CH═CBr₂) Ph(2-F,3-Cl) Ph(2-F,3-CO₂Me) Ph(2-F,3-CH₂CH═CH₂) Ph(2-F,3-F) Ph(2-F,3-OCO₂Me) Ph(2-F,3-CH₂CH═CF₂) Ph(2-F,3-Br) Ph(2-F,3-TMS) Ph(2-F,3-CH₂CH═CCl₂) Ph(2-F,3-I) Ph(2-F,3-Ph) Ph(2-F,3-CH₂CH═CBr₂) Ph(2-F,3-Me) Ph(2-F,3-OCH₂CH═CH₂) Ph(2-F,3-Et) Ph(2-F,3-OCHHd 2CH═CF₂) Ph(2-F,3-n-Pr) Ph[3-(2-F,1H-imidazol-1-yl)] Ph(2-F,3-OCH₂CH═CCl₂) Ph(2-F,3-t-Bu) Ph[3-(2-F,3-pyridinyl)] Ph(2-F,3-OCH₂CH═CBr₂) Ph(2-F,3-SCF₂H) 2-Thienyl(5-c-Pr) Ph(4-c-Pr) Ph(2-F,3-SCF₂CF₂H) 2-Thienyl(5-CF₂H) Ph(4-cyclohexyl) 4-Pyridinyl(2-CF₃) 2-Thienyl(5-OCF₂H) Ph(4-CH═CH₂) 4-Pyridinyl(2-Cl) 2-Thienyl(5-OCF₂CF₂H) Ph(4-CF₃) 4-Pyridinyl(2-F) 2-Thienyl(5-OCF₂CF₃) Ph(4-CH₂CF₃) 4-Pyridinyl(5-OCF₂H) 2-Furanyl(4-F) Ph(4-CHF₂) 4-Pyridinyl(5-CF₂H) 2-Furanyl(4-Cl) Ph(4-CH₂F) 4-Pyridinyl(5-OCF₂CF₂H) 2-Furanyl(4-CF₃) Ph(4-OCF₃) 4-Pyridinyl(2-OCF₃) 2-Furanyl(5-F) Ph(4-OCH 4-Pyridinyl(2-Me) 2-Furanyl(5-Cl) Ph(4-OCHF₂) 4-Pyridinyl(2-Br) 2-Furanyl(5-CF₃) Ph(4-SCF₃) 4-Pyridinyl 2-Furanyl(4-Me) Ph(4-SMe) 1H-Pyrazol-4-yl(1-Me) 2-Furanyl(4-Et) Ph(4-SOMe) 1H-Pyrazol-4-yl(1-CH₂CF₃) 2-Furanyl(4-i-Pr) Ph(4-SO₂Me) 1H-Imidazol-2-yl(1-Me) 2-Furanyl(4-c-Pr) Ph(4-OSO₂Me) 1H-Imidazol-2-yl(1-CH₂CF₃) 2-Furanyl(4-CF₂H) Ph(4-C≡CH) 1H-Imidazol-2-yl(1-Me,5-Cl) 2-Furanyl(4-OCF₂H) Ph(4-OMe) 1H-Imidazol-2-yl(1-Me,5-F) 2-Furanyl(4-OCF₂CF₂H) Ph(4-OEt) 2-Thienyl 2-Furanyl(5-Me) Ph(4-NHCO₂-t-Bu) 2-Thienyl(4-F) 2-Furanyl(5-Et) Ph(4-NHCOMe) 2-Thienyl(4-Cl) 2-Furanyl(5-i-Pr) Ph(4-NHCOCF₃) 2-Thienyl(4-CF₃) 2-Furanyl(5-c-Pr) Ph(4-CN) 2-Thienyl(5-F) 2-Furanyl(5-CF₂H) Ph(4-NO₂) 2-Thienyl(5-Cl) 2-Furanyl(5-OCF₂H) Ph(4-Ph) 2-Thienyl(5-CF₃) 2-Furanyl(5-OCF₂CF₂H) Ph(4-COMe) 2-Thienyl(4-Me) 2-Furanyl(5-OCF₂CF₃) Ph(4-OCOMe) 2-Thienyl(4-Et) Ph(4-Cl) Ph(4-CO₂Me) 2-Thienyl(4-i-Pr) Ph(4-F) Ph(4-OCO₂Me) 2-Thienyl(4-c-Pr) Ph(4-Br) Ph(4-TMS) 2-Thienyl(4-CF₂H) Ph(4-I) Ph(4-Ph) 2-Thienyl(4-OCF₂H) Ph(4-Me) Ph(4-CF₂CF3) 2-Thienyl(4-OCF₂CF₂H) Ph(4-Et) Ph(4-CF₂CF₂H) 2-Thienyl(5-Me) Ph(4-n-Pr) Ph(4-OCF₂CF₂H) 2-Thienyl(5-Et) Ph(4-t-Bu) Ph(4-OCF₂CF₃) 2-Thienyl(5-i-Pr) Ph(4-i-Pr) Ph(4-OCH₂CF₃) Ph(4-OCH₂C≡CH) Ph(2-Cl,4-Et) Ph(2-Cl,4-CF₂CF₂H) Ph(4-OCH₂C≡CCF₃) Ph(2-Cl,4-n-Pr) Ph(2-Cl,4-OCF₂CF₂H) Ph(4-OCH₂C≡CCF₂H) Ph(2-Cl,4-t-Bu) Ph(2-Cl,4-OCF₂CF₃) Ph(4-OCH₂C≡CCH₃) Ph(2-Cl,4-i-Pr) Ph(2-Cl,4-OCH₂CF₃) Ph(4-OCH₂C≡C-c-Pr) Ph(2-Cl,4-c-Pr) Ph(2-Cl,4-OCH₂C≡CH) Ph(4-C≡CCF₂H) Ph(2-Cl,4-cyclohexyl) Ph(2-Cl,4-OCH₂C≡CCF₃) Ph(4-C≡CCH₃) Ph(2-Cl,4-CH═CH₂) Ph(2-Cl,4-OCH₂C≡CCF₂H) Ph(4-C≡C-c-Pr) Ph(2-Cl,4-CF₃) Ph(2-Cl,4-OCH₂C≡CCH₃) Ph(4-OPh) Ph(2-Cl,4-CH₂CF₃) Ph(2-Cl,4-OCH₂C≡C-c-Pr) Ph(4-C≡CCF₃) Ph(2-Cl,4-CHF₂) Ph(2-Cl,4-C≡CCF₂H) Ph(4-C≡CCF₂H) Ph(2-Cl,4-CH₂F) Ph(2-Cl,4-C≡CCH₃) Ph(4-C≡CCH₃) Ph(2-Cl,4-OCF₃) Ph(2-Cl,4-C≡C-c-Pr) Ph(4-C≡C-c-Pr) Ph(2-Cl,4-OCH₂F) Ph(2-Cl,4-OPh) Ph(4-CH═CF₂) Ph(2-Cl,4-OCHF₂) Ph(2-Cl,4-C≡CCF₃) Ph(4-CH═CCl₂) Ph(2-Cl,4-SCF₃) Ph(2-Cl,4-C≡CCF₂H) Ph(4-OCH═CBr₂) Ph(2-Cl,4-SMe) Ph(2-Cl,4-C≡CCH₃) Ph(4-OCH═CH₂) Ph(2-Cl,4-SOMe) Ph(2-Cl,4-C≡C-c-Pr) Ph(4-OCH═CF₂) Ph(2-Cl,4-SO₂Me) Ph(2-Cl,4-CH═CF₂) Ph(4-OCH═CCl₂) Ph(2-Cl,4-OSO₂Me) Ph(2-Cl,4-CH═CCl₂) Ph(4-OCH═CBr₂) Ph(2-Cl,4-C≡CH) Ph(2-Cl,4-CH═CBr₂) Ph(4-CH₂CH═CH₂) Ph(2-Cl,4-OMe) Ph(2-Cl,4-OCH═CH₂) Ph(4-CH₂CH═CF₂) Ph(2-Cl,4-OEt) Ph(2-Cl,4-OCH═CF₂) Ph(4-CH₂CH═CCl₂) Ph(2-Cl,4-NHCO₂-t-Bu) Ph(2-Cl,4-OCH═CCl₂) Ph(4-CH₂CH═CBr₂) Ph(2-Cl,4-NHCOMe) Ph(2-Cl,4-OCH═CBr₂) Ph(4-OCH₂CH═CH₂) Ph(2-Cl,4-NHCOCF₃) Ph(2-Cl,4-CH₂CH═CH₂) Ph(4-OCH₂CH═CF₂) Ph(2-Cl,4-CN) Ph(2-Cl,4-CH₂CH═CF₂) Ph(4-OCH₂CH═CCl₂) Ph(2-Cl,4-NO₂) Ph(2-Cl,4-CH₂CH═CCl₂) Ph(4-OCH₂CH═CBr₂) Ph(2-Cl,4-Ph) Ph(2-Cl,4-CH₂CH═CBr₂) Ph(4-SCF₂H) Ph(2-Cl,4-COMe) Ph(2-Cl,4-OCH₂CH═CH₂) Ph(4-SCF₂CF₂H) Ph(2-Cl,4-OCOMe) Ph(2-Cl,4-OCH₂CH═CF₂) Ph(2,4-di-Cl) Ph(2-Cl,4-CO₂Me) Ph(2-Cl,4-OCH₂CH═CCl₂) Ph(2-Cl,4-F) Ph(2-Cl,4-OCO₂Me) Ph(2-Cl,4-OCH₂CH═CBr₂) Ph(2-Cl,4-Br) Ph(2-Cl,4-TMS) Ph(2-Cl,4-SCF₂H) Ph(2-Cl,4-I) Ph(2-Cl,4-Ph) Ph(2-Cl,4-SCF₂CF₂H) Ph(2-Cl,4-Me) Ph(2-Cl,4-CF₂CF₃) Ph(2-F,4-Cl) Ph(2,4-di-F) Ph(2-F,4-OCO₂Me) Ph(2-F,4-OCH₂CH═CBr₂) Ph(2-F,4-Br) Ph(2-F,4-TMS) Ph(2-F,4-SCF₂H) Ph(2-F,4-I) Ph(2-F,4-Ph) Ph(2-F,4-SCF₂CF₂H) Ph(2-F,4-Me) Ph(2-F,4-CF₂CF₃) Ph(1H-pyrazol-1-yl) Ph(2-F,4-Et) Ph(2-F,4-CF₂CF₂H) Ph(2H-1,2,3-triazol-2-yl) Ph(2-F,4-n-Pr) Ph(2-F,4-OCF₂CF₂H) Ph(1H-imidazol-1-yl) Ph(2-F,4-t-Bu) Ph(2-F,4-OCF₂CF₃) Ph[4-(3-pyridinyl)] Ph(2-F,4-i-Pr) Ph(2-F,4-OCH₂CF₃) Ph[4-(4-pyridinyl)] Ph(2-F,4-c-Pr) Ph(2-F,4-OCH₂C≡CH) Ph[4-(2-pyridinyl)] Ph(2-F,4-cyclohexyl) Ph(2-F,4-OCH₂C≡CCF₃) 3-pyridinyl(5-CF₃) Ph(2-F,4-CH═CH₂) Ph(2-F,4-OCH₂C≡CCF₂H) 3-Pyridinyl(5-Cl) Ph(2-F,4-CF₃) Ph(2-F,4-OCH₂C≡CCH₃) 3-Pyridinyl(5-F) Ph(2-F,4-CH₂CF₃) Ph(2-F,4-OCH₂C≡C-c-Pr) 3-Pyridinyl(5-OCF₂H) Ph(2-F,4-CHF₂) Ph(2-F,4-C≡CCF₂H) 3-Pyridinyl(5-CF₂H) Ph(2-F,4-CH₂F) Ph(2-F,4-C≡CCH₃) 3-Pyridinyl(5-F) Ph(2-F,4-OCF₃) Ph(2-F,4-C≡C-c-Pr) 3-Pyridinyl(5-OCF₃) Ph(2-F,4-OCH₂F) Ph(2-F,4-OPh) 3-Pyridinyl(5-Me) Ph(2-F,4-OCH₂) Ph(2-F,4-C≡CCF₃) 3-Pyridinyl(5-Br) Ph(2-F,4-SCF₃) Ph(2-F,4-C≡CCF₂H) 3-Pyridinyl Ph(2-F,4-SMe) Ph(2-F,4-C≡CCH₃) 1H-Pyrazol-3-yl(1-Me) Ph(2-F,4-SOMe) Ph(2-F,4-C≡C—c-Pr) 1H-Pyrazol-3-yl(1-CH₂CF₃) Ph(2-F,4-SO₂Me) Ph(2-F,4-CH═CF₂) 1H-Pyrazol-3-yl(1-Me,4-F) Ph(2-F,4-OSO₂Me) Ph(2-F,4-CH═CCl₂) 1H-Pyrazol-3-yl(1-Me,4-Cl) Ph(2-F,4-C≡CH) Ph(2-F,4-CH═CBr₂) 1H-Imidazol-5-yl(1-Me) Ph(2-F,4-OMe) Ph(2-F,4-OCH═CH₂) 1H-Imidazol-5-yl(1-CH₂CF₃) Ph(2-F,4-OEt) Ph(2-F,4-OCH═CF₂) 1H-Imidazol-4-yl(1-Me) Ph(2-F,4-NHCO₂-t-Bu) Ph(2-F,4-OCH═CCl₂) 1H-Imidazol-4-yl(1-CH₂CF₃) Ph(2-F,4-NHCOMe) Ph(2-F,4-OCH═CBr₂) 3-Thienyl Ph(2-F,4-NHCOCF₃) Ph(2-F,4-CH₂CH═CH₂) 3-Thienyl(5-F) Ph(2-F,4-CN) Ph(2-F,4-CH₂CH═CF₂) 3-Thienyl(5-Cl) Ph(2-F,4-NO₂) Ph(2-F,4-CH₂CH═CCl₂) 3-Thienyl(5-CF₃) Ph(2-F,4-Ph) Ph(2-F,4-CH₂CH═CBr₂) 3-Thienyl(4-Me) Ph(2-F,4-COMe) Ph(2-F,4-OCH₂CH═CH₂) 3-Thienyl(4-Et) Ph(2-F,4-OCOMe) Ph(2-F,4-OCH₂CH═CF₂) 3-Thienyl(4-i-Pr) Ph(2-F,4-CO₂Me) Ph(2-F,4-OCH₂CH═CCl₂) 3-Thienyl(4-c-Pr) 3-Thienyl(4-CF₂H) Ph(3-Cl,4-TMS) Ph(3-Br,4-CF₂CF₃) 3-Thienyl(4-OCF₂H) Ph(3-Cl,4-CN) Ph(3-Br,4-CF₂CF₂H) 3-Thienyl(4-OCF₂CF₂H) Ph(3-F,4-Cl) Ph(3-Br,4-CF₂H) 3-Thienyl(4-OCF₂CF₃) Ph(3,4-di-F) Ph(3-Br,4-OMe) 3-Furanyl(5-F) Ph(3-F,4-Br) Ph(3-Br,4-OCF₃) 3-Furanyl(5-Cl) Ph(3-F,4-I) Ph(3-Br,4-OCHF₂) 3-Furanyl(5-CF₃) Ph(3-F,4-Me) Ph(3-Br,4-OCF₂CF₂H) 3-Furanyl(4-Me) Ph(3-F,4-Et) Ph(3-Br,4-OCF₂CF₃) 3-Furanyl(4-Et) Ph(3-F,4-n-Pr) Ph(3-Br,4-SO₂Me) 3-Furanyl(4-i-Pr) Ph(3-F,4-t-Bu) Ph(3-Br,4-TMS) 3-Furanyl(4-c-Pr) Ph(3-F,4-i-Pr) Ph(3-Br,4-CN) 3-Furanyl(4-CF₂H) Ph(3-F,4-c-Pr) Ph(3-I,4-Cl) 3-Furanyl(4-OCF₂H) Ph(3-F,4-CF₃) Ph(3-I,4-F) 3-Furanyl(4-OCF₂CF₂H) Ph(3-F,4-CF₂CF₃) Ph(3-I,4-Br) 3-Furanyl(4-OCF₂CF₃) Ph(3-F,4-CF₂CF₂H) Ph(3,4-di-I) Ph(3,4-di-Cl) Ph(3-F,4-CF₂H) Ph(3-I,4-Me) Ph(3-Cl,4-F) Ph(3-F,4-OMe) Ph(3-I,4-Et) Ph(3-Cl,4-Br) Ph(3-F,4-OCF₃) Ph(3-I,4-n-Pr) Ph(3-Cl,4-I) Ph(3-F,4-OCH₂) Ph(3-I,4-t-Bu) Ph(3-Cl,4-Me) Ph(3-F,4-OCF₂CF₂H) Ph(3-I,4-i-Pr) Ph(3-Cl,4-Et) Ph(3-F,4-OCF₂CF₃) Ph(3-I,4-c-Pr) Ph(3-Cl,4-n-Pr) Ph(3-F,4-SO₂Me) Ph(3-I,4-CF₃) Ph(3-Cl,4-t-Bu) Ph(3-F,4-TMS) Ph(3-I,4-CF₂CF₃) Ph(3-Cl,4-i-Pr) Ph(3-F,4-CN) Ph(3-I,4-CF₂CF₂H) Ph(3-Cl,4-c-Pr) Ph(3-Br,4-Cl) Ph(3-I,4-CF₂H) Ph(3-Cl,4-CF₃) Ph(3-Br,4-F) Ph(3-I,4-OMe) Ph(3-Cl,4-CF₃) Ph(3,4-di-Br) Ph(3-I,4-OCF₃) Ph(3-Cl,4-CF₂CF₂H) Ph(3-Br,4-I) Ph(3-I,4-OCHF₂) Ph(3-Cl,4-CF₂H) Ph(3-Br,4-Me) Ph(3-I,4-OCF₂CF₂H) Ph(3-Cl,4-OMe) Ph(3-Br,4-Et) Ph(3-I,4-OCF₂CF₃) Ph(3-Cl,4-OCF₃) Ph(3-Br,4-n-Pr) Ph(3-I,4-SO₂Me) Ph(3-Cl,4-OCHF₂) Ph(3-Br,4-t-Bu) Ph(3-I,4-TMS) Ph(3-Cl,4-OCF₂CF₂H) Ph(3-Br,4-i-Pr) Ph(3-I,4-CN) Ph(3-Cl,4-OCF₂CF₃) Ph(3-Br,4-c-Pr) Ph(3-Me,4-Cl) Ph(3-Cl,4-SO₂Me) Ph(3-Br,4-CF₃) Ph(3-Me,4-F) Ph(3-Me,4-Br) Ph(3-Et,4-OCF₃) Ph(3-t-Bu,4-n-Pr) Ph(3-Me,4-I) Ph(3-Et,4-OCHF₂) Ph(3,4-di-t-Bu) Ph(3,4-di-Me) Ph(3-Et,4-OCF₂CF₂H) Ph(3-t-Bu,4-i-Pr) Ph(3-Me,4-Et) Ph(3-Et,4-OCF₂CF₃) Ph(3-t-Bu,4-c-Pr) Ph(3-Me,4-n-Pr) Ph(3-Et,4-SO₂Me) Ph(3-t-Bu,4-CF₃) Ph(3-Me,4-t-Bu) Ph(3-Et,4-TMS) Ph(3-t-Bu,4-CF₂CF₃) Ph(3-Me,4-i-Pr) Ph(3-Et,4-CN) Ph(3-t-Bu,4-CF₂CF₂H) Ph(3-Me,4-c-Pr) Ph(3-n-Pr,4-Cl) Ph(3-t-Bu,4-CF₂H) Ph(3-Me,4-CF₃) Ph(3-n-Pr,4-F) Ph(3-t-Bu,4-OMe) Ph(3-Me,4-CF₂CF₃) Ph(3-n-Pr,4-Br) Ph(3-t-Bu,4-OCF₃) Ph(3-Me,4-CF₂CF₂H) Ph(3-n-Pr,4-I) Ph(3-t-Bu,4-OCHF₂) Ph(3-Me,4-CF₂H) Ph(3-n-Pr,4-Me) Ph(3-t-Bu,4-OCF₂CF₂H) Ph(3-Me,4-OMe) Ph(3-n-Pr,4-Et) Ph(3-t-Bu,4-OCF₂CF₃) Ph(3-Me,4-OCF₃) Ph(3,4-di-n-Pr) Ph(3-t-Bu,4-SO₂Me) Ph(3-Me,4-OCHF₂) Ph(3-n-Pr,4-t-Bu) Ph(3-t-Bu,4-TMS) Ph(3-Me,4-OCF₂CF₂H) Ph(3-n-Pr,4-i-Pr) Ph(3-t-Bu,4-CN) Ph(3-Me,4-OCF₂CF₃) Ph(3-n-Pr,4-c-Pr) Ph(3-i-Pr,4-Cl) Ph(3-Me,4-SO₂Me) Ph(3-n-Pr,4-CF₃) Ph(3-i-Pr,4-F) Ph(3-Me,4-TMS) Ph(3-n-Pr,4-CF₂CF₃) Ph(3-i-Pr,4-Br) Ph(3-Me,4-CN) Ph(3-n-Pr,4-CF₂CF₂H) Ph(3-i-Pr,4-I) Ph(3-Et,4-Cl) Ph(3-n-Pr,4-CF₂H) Ph(3-i-Pr,4-Me) Ph(3-Et,4-F) Ph(3-n-Pr,4-OMe) Ph(3-i-Pr,4-Ei) Ph(3-Et,4-Br) Ph(3-n-Pr,4-OCF₃) Ph(3-i-Pr,4-n-Pr) Ph(3-Et,4-I) Ph(3-n-Pr,4-OCHF₂) Ph(3-i-Pr,4-t-Bu) Ph(3-Et,4-Me) Ph(3-n-Pr,4-OCF₂CF₂H) Ph(3,4-di-i-Pr) Ph(3,4-di-Et) Ph(3-n-Pr,4-OCF₂CF₃) Ph(3-i-Pr,4-c-Pr) Ph(3-Et,4-n-Pr) Ph(3-n-Pr,4-SO₂Me) Ph(3-i-Pr,4-CF₃) Ph(3-Et,4-t-Bu) Ph(3-n-Pr,4-TMS) Ph(3-i-Pr,4-CF₂CF₃) Ph(3-Et,4-i-Pr) Ph(3-n-Pr,4-CN) Ph(3-i-Pr,4-CF₂CF₂H) Ph(3-Et,4-c-Pr) Ph(3-t-Bu,4-Cl) Ph(3-i-Pr,4-CF₂H) Ph(3-Et,4-CF₃) Ph(3-t-Bu,4-F) Ph(3-i-Pr,4-OMe) Ph(3-Et,4-CF₂CF₃) Ph(3-t-Bu,4-Br) Ph(3-i-Pr,4-OCF₃) Ph(3-Et,4-CF₂CF₂H) Ph(3-t-Bu,4-I) Ph(3-i-Pr,4-OCHF₂) Ph(3-Et,4-CF₂H) Ph(3-t-Bu,4-Me) Ph(3-i-Pr,4-OCF₂CF₂H) Ph(3-Et,4-OMe) Ph(3-t-Bu,4-Et) Ph(3-i-Pr,4-OCF₂CF₃) Ph(3-i-Pr,4-SO₂Me) Ph(3,4-di-CF₃) Ph(3-CF₂CF₂H,4-F) Ph(3-i-Pr,4-TMS) Ph(3-CF₃,4-CF₂CF₃) Ph(3-CF₂CF₂H,4-Br) Ph(3-i-Pr,4-CN) Ph(3-CF₃,4-CF₂CF₂H) Ph(3-CF₂CF₂H,4-I) Ph(3-c-Pr,4-Cl) Ph(3-CF₃,4-CF₂H) Ph(3-CF₂CF₂H,4-Me) Ph(3-c-Pr,4-F) Ph(3-CF₃,4-OMe) Ph(3-CF₂CF₂H,4-Ei) Ph(3-c-Pr,4-Br) Ph(3-CF₃,4-OCF₃) Ph(3-CF₂CF₂H,4-n-Pr) Ph(3-c-Pr,4-I) Ph(3-CF₃,4-OCHF₂) Ph(3-CF₂CF₂H,4-t-Bu) Ph(3-c-Pr,4-Me) Ph(3-CF₃,4-OCF₂CF₂H) Ph(3-CF₂CF₂H,4-i-Pr) Ph(3-c-Pr,4-Ei) Ph(3-CF₃,4-OCF₂CF₃) Ph(3-CF₂CF₂H,4-c-Pr) Ph(3-c-Pr,4-n-Pr) Ph(3-CF₃,4-SO₂Me) Ph(3-CF₂CF₂HCF₃,4-CF₃) Ph(3-c-Pr,4-t-Bu) Ph(3-CF₃,4-IMS) Ph(3-CF₂CF₂H,4-CF₂CF₃) Ph(3-c-Pr,4-i-Pr) Ph(3-CF₃,4-CN) Ph(3,4-di-CF₂CF₂H) Ph(3,4-di-c-Pr) Ph(3-CF₂CF₃,4-Cl) Ph(3-CF₂CF₂H,4-CF₂H) Ph(3-c-Pr,4-CF₃) Ph(3-CF₂CF₃,4-F) Ph(3-CF₂CF₂H,4-OMe) Ph(3-c-Pr,4-CF₂CF₃) Ph(3-CF₂CF₃,4-Br) Ph(3-CF₂CF₂H,4-OCF₃) Ph(3-c-Pr,4-CF₂CF₂H) Ph(3-CF₂CF₃,4-I) Ph(3-CF₂CF₂H,4-OCHF₂) Ph(3-c-Pr,4-CF₂H) Ph(3-CF₂CF₃,4-Me) Ph(3-CF₂CF₂H,4-OCF₂CF₂H) Ph(3-c-Pr,4-OMe) Ph(3-CF₂CF₃,4-Ei) Ph(3-CF₂CF₂H,4-OCF₂CF₃) Ph(3-c-Pr,4-OCF₃) Ph(3-CF₂CF₃,4-n-Pr) Ph(3-CF₂CF₂H,4-SO₂Me) Ph(3-c-Pr,4-OCHF₂) Ph(3-CF₂CF₃,4-t-Bu) Ph(3-CF₂CF₂H,4-TMS) Ph(3-c-Pr,4-OCF₂CF₂H) Ph(3-CF₂CF₃,4-i-Pr) Ph(3-CF₂CF₂H,4-CN) Ph(3-c-Pr,4-OCF₂CF₃) Ph(3-CF₂CF₃,4-c-Pr) Ph(3-CF₂H,4-Cl) Ph(3-c-Pr,4-SO₂Me) Ph(3-CF₂CF₃CF₃,4-CF₃) Ph(3-CF₂H,4-F) Ph(3-c-Pr,4-TMS) Ph(3,4-di-CF₂CF₃) Ph(3-CF₂H,4-Br) Ph(3-c-Pr,4-CN) Ph(3-CF₂CF₃,4-CF₂CF₂H) Ph(3-CF₂H,4-I) Ph(3-CF3,4-Cl) Ph(3-CF₂CF₃,4-CF₂H) Ph(3-CF₂H,4-Me) Ph(3-CF3,4-F) Ph(3-CF₂CF₃,4-OMe) Ph(3-CF₂H,4-Ei) Ph(3-CF3,4-Br) Ph(3-CF₂CF₃,4-OCF₃) Ph(3-CF₂H,4-n-Pr) Ph(3-CF3,4-I) Ph(3-CF₂CF₃,4-OCHF₂) Ph(3-CF₂H,4-t-Bu) Ph(3-CF3,4-Me) Ph(3-CF₂CF₃,4-OCF₂CF₂H) Ph(3-CF₂H,4-i-Pr) Ph(3-CF3,4-Et) Ph(3-CF₂CF₃,4-OCF₂CF₃) Ph(3-CF₂H,4-c-Pr) Ph(3-CF3,4-n-Pr) Ph(3-CF₂CF₃,4-SO₂Me) Ph(3-CF₂H,4-CF₃) Ph(3-CF3,4-t-Bu) Ph(3-CF₂CF₃,4-TMS) Ph(3-CF₂H,4-CF₂CF₃) Ph(3-CF3,4-i-Pr) Ph(3-CF₂CF₃,4-CN) Ph(3-CF₂H,4-CF₂CF₂H) Ph(3-CF3,4-c-Pr) Ph(3-CF₂CF₂H,4-Cl) Ph(3,4-di-CF₂H) Ph(3-CF₂H,4-OMe) Ph(3-OCF₃,4-Ei) Ph(3-OCHF₂,4-OCF₂CF₃) Ph(3-CF₂H,4-OCF₃) Ph(3-OCF₃,4-n-Pr) Ph(3-OCHF₂,4-SO₂Me) Ph(3-CF₂H,4-OCHF₂) Ph(3-OCF₃,4-t-Bu) Ph(3-OCHF₂,4-TMS) Ph(3-CF₂H,4-OCF₂CF₂H) Ph(3-OCF₃,4-i-Pr) Ph(3-OCHF₂,4-CN) Ph(3-CF₂H,4-OCF₂CF₃) Ph(3-OCF₃,4-c-Pr) Ph(3-OCF₂CF₂H,4-Cl) Ph(3-CF₂H,4-SO₂Me) Ph(3-OCF₃,4-CF₃) Ph(3-OCF₂CF₂H,4-F) Ph(3-CF₂H,4-TMS) Ph(3-OCF₃,4-CF₃) Ph(3-OCF₂CF₂H,4-Br) Ph(3-CF₂H,4-CN) Ph(3-OCF₃,4-CF₂CF₂H) Ph(3-OCF₂CF₂H,4-I) Ph(3-OMe,4-Cl) Ph(3-OCF₃,4-CF₂H) Ph(3-OCF₂CF₂H,4-Me) Ph(3-OMe,4-F) Ph(3-OCF₃,4-OMe) Ph(3-OCF₂CF₂H,4-Ei) Ph(3-OMe,4-Br) Ph(3,4-di-OCF₃) Ph(3-OCF₂CF₂H,4-n-Pr) Ph(3-OMe,4-I) Ph(3-OCF₃,4-OCHF₂) Ph(3-OCF₂CF₂H,4-t-Bu) Ph(3-OMe,4-Me) Ph(3-OCF₃,4-OCF₂CF₂H) Ph(3-OCF₂CF₂H,4-i-Pr) Ph(3-OMe,4-Ei) Ph(3-OCF₃,4-OCF₂CF₃) Ph(3-OCF₂CF₂H,4-c-Pr) Ph(3-OMe,4-n-Pr) Ph(3-OCF₃,4-SO₂Me) Ph(3-OCF₂CF₂HCF₃,4-CF₃) Ph(3-OMe,4-t-Bu) Ph(3-OCF₃,4-TMS) Ph(3-OCF₂CF₂H,4-CF₂CF₃) Ph(3-OMe,4-i-Pr) Ph(3-OCF₃,4-CN) Ph(3-OCF₂CF₂H,4-CF₂CF₂H) Ph(3-OMe,4-c-Pr) Ph(3-OCHF₂,4-Cl) Ph(3-OCF₂CF₂H,4-CF₂H) Ph(3-OMeCF₃,4-CF₃) Ph(3-OCHF₂,4-F) Ph(3-OCF₂CF₂H,4-OMe) Ph(3-OMe,4-CF₂CF₃) Ph(3-OCHF₂,4-Br) Ph(3-OCF₂CF₂H,4-OCF₃) Ph(3-OMe,4-CF₂CF₂H) Ph(3-OCHF₂,4-I) Ph(3-OCF₂CF₂H,4-OCHF₂) Ph(3-OMe,4-CF₂H) Ph(3-OCHF₂,4-Me) Ph(3,4-di-OCF₂CF₂H) Ph(3,4-di-OMe) Ph(3-OCHF₂,4-Ei) Ph(3-OCF₂CF₂H,4-OCF₂CF₃) Ph(3-OMe,4-OCF₃) Ph(3-OCHF₂,4-n-Pr) Ph(3-OCF₂CF₂H,4-SO₂Me) Ph(3-OMe,4-OCHF₂) Ph(3-OCHF₂,4-t-Bu) Ph(3-OCF₂CF₂H,4-TMS) Ph(3-OMe,4-OCF₂CF₂H) Ph(3-OCHF₂,4-i-Pr) Ph(3-OCF₂CF₂H,4-CN) Ph(3-OMe,4-OCF₂CF₃) Ph(3-OCHF₂,4-c-Pr) Ph(3-OCF₂CF₃,4-Cl) Ph(3-OMe,4-SO₂Me) Ph(3-OCHF₂CF₃,4-CF₃) Ph(3-OCF₂CF₃,4-F) Ph(3-OMe,4-TMS) Ph(3-OCF₂CF₃,4-CF₂CF₃) Ph(3-OCF₂CF₃,4-Br) Ph(3-OMe,4-CN) Ph(3-OCHF₂,4-CF₂CF₂H) Ph(3-OCF₂CF₃,4-I) Ph(3-OCF₃,4-Cl) Ph(3-OCHF₂,4-CF₂H) Ph(3-OCF₂CF₃,4-Me) Ph(3-OCF₃,4-F) Ph(3-OCHF₂,4-OMe) Ph(3-OCF₂CF₃,4-Ei) Ph(3-OCF₃,4-Br) Ph(3-OCHF₂,4-OCF₃) Ph(3-OCF₂CF₃,4-n-Pr) Ph(3-OCF₃,4-I) Ph(3,4-di-OCHF₂) Ph(3-OCF₂CF₃,4-t-Bu) Ph(3-OCF_(3,)4-Me) Ph(3-OCHF₂,4-OCF₂CF₂H) Ph(3-OCF₂CF₃,4-i-Pr) Ph(3-OCF₂CF₃,4-c-Pr) Ph(3-TMS,4-Cl) Ph(3-CN,4-CF₂H) Ph(3-OCF₂CF₃CF₃,4-CF₃) Ph(3-TMS,4-F) Ph(3-CN,4-OMe) Ph(3-OCF₂CF₃,4-CF₂CF₃) Ph(3-TMS,4-Br) Ph(3-CN,4-OCF₃) Ph(3-Ph(3-OCF₂CF₃,4-CF₂CF₂H) Ph(3-TMS,4-I) Ph(3-CN,4-OCHF₂) Ph(3-OCF₂CF₃,4-CF₂H) Ph(3-TMS,4-Me) Ph(3-CN,4-OCF₂CF₂H) Ph(3-OCF₂CF₃,4-OMe) Ph(3-TMS,4-Ei) Ph(3-CN,4-OCF₂CF₃) Ph(3-OCF₂CF₃,4-OCF₃) Ph(3-TMS,4-n-Pr) Ph(3-CN,4-SO₂Me) Ph(3-OCF₂CF₃,4-OCHF₂) Ph(3-TMS,4-t-Bu) Ph(3-CN,4-TMS) Ph(3-OCF₂CF₃,4-OCF₂CF₂H) Ph(3-TMS,4-i-Pr) Ph(3,4-di-CN) Ph(3,4-di-OCF₂CF₃) Ph(3-TMS,4-c-Pr) Ph(3,5-di-Cl) Ph(3-OCF₂CF₃,4-SO₂Me) Ph(3-TMS,4-CF₃) Ph(3-Cl,5-F) Ph(3-OCF₂CF₃,4-TMS) Ph(3-TMS,4-CF₂CF₃) Ph(3-Cl,5-Br) Ph(3-OCF₂CF₃,4-CN) Ph(3-TMS,4-CF₂CF₂H) Ph(3-Cl,5-I) Ph(3-SO₂Me,4-Cl) Ph(3-TMS,4-CF₂H) Ph(3-Cl,5-Me) Ph(3-SO₂Me,4-F) Ph(3-TMS,4-OMe) Ph(3-Cl,5-Et) Ph(3-SO₂Me,4-Br) Ph(3-TMS,4-OCF₃) Ph(3-Cl,5-n-Pr) Ph(3-SO₂Me,4-I) Ph(3-TMS,4-OCHF₂) Ph(3-Cl,5-t-Bu) Ph(3-SO₂Me,4-Me Ph(3-TMS,4-OCF₂CF₂H) Ph(3-Cl,5-i-Pr) Ph(3-SO₂Me,4-Ei) Ph(3-TMS,4-OCF₂CF₃) Ph(3-Cl,5-c-Pr) Ph(3-SO₂Me,4-n-Pr) Ph(3-TMS,4-SO₂Me) Ph(3-Cl,5-CF₃) Ph(3-SO₂Me,4-t-Bu) Ph(3,4-di-TMS) Ph(3-Cl,5-CF₂CF₃) Ph(3-SO₂Me,4-i-Pr) Ph(3-TMS,4-CN) Ph(3-Cl,5-CF₂CF₂H) Ph(3-SO₂Me,4-c-Pr) Ph(3-CN,4-Cl) Ph(3-Cl,5-CF₂H) Ph(3-SO₂MeCF₃,4-CF₃) Ph(3-CN,4-F) Ph(3-Cl,5-OMe) Ph(3-SO₂Me,4-CF₂CF₃) Ph(3-CN,4-Br) Ph(3-Cl,5-OCF₃) Ph(3-SO₂Me,4-CF₂CF₂H) Ph(3-CN,4-I) Ph(3-Cl,5-OCHF₂) Ph(3-SO₂Me,4-CF₂H) Ph(3-CN,4-Me) Ph(3-Cl,5-OCF₂CF₂H) Ph(3-SO₂Me,4-OMe) Ph(3-CN,4-Ei) Ph(3-Cl,5-OCF₂CF₃) Ph(3-SO₂Me,4-OCF₃) Ph(3-CN,4-n-Pr) Ph(3-Cl,5-SO₂Me) Ph(3-SO₂Me,4-OCHF₂) Ph(3-CN,4-t-Bu) Ph(3-Cl,5-TMS) Ph(3-SO₂Me,4-OCF₂CF₂H) Ph(3-CN,4-i-Pr) Ph(3-Cl,5-CN) Ph(3-SO₂Me,4-OCF₂CF₃) Ph(3-CN,4-c-Pr) Ph(3-F,5-Cl) Ph(3,4-di-SO₂Me) Ph(3-CN,4-CF₃) Ph(3,5-di-F) Ph(3-SO₂Me,4-TMS) Ph(3-CN,4-CF₂CF₃) Ph(3-F,5-Br) Ph(3-SO₂Me,4-CN) Ph(3-CN,4-CF₂CF₂H) Ph(3-F,5-I) Ph(3-F,5-Me) Ph(3-Br,5-OCF₂CF₂H) Ph(3-Me,5-i-Pr) Ph(3-F,5-Et) Ph(3-Br,5-OCF₂CF₃) Ph(3-Me,5-c-Pr) Ph(3-F,5-n-Pr) Ph(3-Br,5-SO₂Me) Ph(3-Me,5-CF₃) Ph(3-F,5-t-Bu) Ph(3-Br,5-TMS) Ph(3-Me,5-CF₂CF₃) Ph(3-F,5-i-Pr) Ph(3-Br,5-CN) Ph(3-Me,5-CF₂CF₂H) Ph(3-F,5-c-Pr) Ph(3-I,5-Cl) Ph(3-Me,5-CF₂H) Ph(3-F,5-CF₃) Ph(3-I,5-F) Ph(3-Me,5-OMe) Ph(3-F,5-CF₂CF₃) Ph(3-I,5-Br) Ph(3-Me,5-OCF₃) Ph(3-F,5-CF₂CF₂H) Ph(3,5-di-I) Ph(3-Me,5-OCHF₂) Ph(3-F,5-CF₂H) Ph(3-I,5-Me) Ph(3-Me,5-OCF₂CF₂H) Ph(3-F,5-OMe) Ph(3-I,5-Et) Ph(3-Me,5-OCF₂CF₃) Ph(3-F,5-OCF₃) Ph(3-I,5-n-Pr) Ph(3-Me,5-SO₂Me) Ph(3-F,5-OCHF₂) Ph(3-I,5-t-Bu) Ph(3-Me,5-TMS) Ph(3-F,5-OCF₂CF₂H) Ph(3-I,5-i-Pr) Ph(3-Me,5-CN) Ph(3-F,5-OCF₂CF₃) Ph(3-I,5-c-Pr) Ph(3-Et,5-Cl) Ph(3-F,5-SO₂Me) Ph(3-I,5-CF₃) Ph(3-Et,5-F) Ph(3-F,5-TMS) Ph(3-I,5-CF₂CF₃) Ph(3-Et,5-Br) Ph(3-F,5-CN) Ph(3-I,5-CF₂CF₂H) Ph(3-Et,5-I) Ph(3-Br,5-Cl) Ph(3-I,5-CF₂H) Ph(3-Et,5-Me) Ph(3-Br,5-F) Ph(3-I,5-OMe) Ph(3,5-di-Et) Ph(3,5-di-Br) Ph(3-I,5-OCF₃) Ph(3-Et,5-n-Pr) Ph(3-Br,5-I) Ph(3-I,5-OCHF₂) Ph(3-Et,5-t-Bu) Ph(3-Br,5-Me) Ph(3-I,5-OCF₂CF₂H) Ph(3-Et,5-i-Pr) Ph(3-Br,5-Et) Ph(3-I,5OOCF₂CF₃) Ph(3-Et,5-c-Pr) Ph(3-Br,5-n-Pr) Ph(3-I,5-SO₂Me) Ph(3-Et,5-CF₃) Ph(3-Br,5-t-Bu) Ph(3-I,5-TMS) Ph(3-Et,5-CF₂CF₃) Ph(3-Br,5-i-Pr) Ph(3-I,5-CN) Ph(3-Et,5-CF₂CF₂H) Ph(3-Br,5-c-Pr) Ph(3-Me,5-Cl) Ph(3-Et,5-CF₂H) Ph(3-Br,5-CF₃) Ph(3-Me,5-F) Ph(3-Et,5-OMe) Ph(3-Br,5-CF₂CF₃) Ph(3-Me,5-Br) Ph(3-Et,5-OCF) Ph(3-Br,5-CF₂CF₂H) Ph(3-Me,5-I) Ph(3-Et,5-OCHF₂) Ph(3-Br,5-CF₂H) Ph(3,5-di-Me) Ph(3-Et,5-OCF₂CF₂H) Ph(3-Br,5-OMe) Ph(3-Me,5-Et) Ph(3-Et,5-OCF₂CF₃) Ph(3-Br,5-OCF₃) Ph(3-Me,5-n-Pr) Ph(3-Et,5-SO₂Me) Ph(3-Br,5-OCHF₂) Ph(3-Me,5-t-Bu) Ph(3-Et,5-TMS) Ph(3-Et,5-CN) Ph(3-t-Bu,5-CF₂CF₂H) Ph(3-c-Pr,5-I) Ph(3-n-Pr,5-Cl) Ph(3-t-Bu,5-CF₂H) Ph(3-c-Pr,5-Me) Ph(3-n-Pr,5-F) Ph(3-t-Bu,5-OMe) Ph(3-c-Pr,5-Ei) Ph(3-n-Pr,5-Br) Ph(3-t-Bu,5-OCF₃) Ph(3-c-Pr,5-n-Pr) Ph(3-n-Pr,5-I) Ph(3-t-Bu,5-OCHF₂) Ph(3-c-Pr,5-t-Bu) Ph(3-n-Pr,5-Me) Ph(3-t-Bu,5-OCF₂CF₃H) Ph(3-c-Pr,5-i-Pr) Ph(3-n-Pr,5-Et) Ph(3-t-Bu,5-OCF₂CF₃) Ph(3,5-di-c-Pr) Ph(3,5-di-n-Pr) Ph(3-t-Bu,5-SO₂Me) Ph(3-c-Pr,5-CF₃) Ph(3-n-Pr,5-t-Bu) Ph(3-t-Bu,5-TMS) Ph(3-c-Pr,5-CF₂CF₃) Ph(3-n-Pr,5-i-Pr) Ph(3-t-Bu,5-CN) Ph(3-c-Pr,5-CF₂CF₂H) Ph(3-n-Pr,5-c-Pr) Ph(3-i-Pr,5-Cl) Ph(3-c-Pr,5-CF₂H) Ph(3-n-Pr,5-CF₃) Ph(3-i-Pr,5-F) Ph(3-c-Pr,5-OMe) Ph(3-n-Pr,5-CF₂CF₃) Ph(3-i-Pr,5-Br) Ph(3-c-Pr,5-OCF₃) Ph(3-n-Pr,5-CF₂CF₂H) Ph(3-i-Pr,5-I) Ph(3-c-Pr,5-OCHF₂) Ph(3-n-Pr,5-CF₂H) Ph(3-i-Pr,5-Me) Ph(3-c-Pr,5-OCF₂CF₃H) Ph(3-n-Pr,5-OMe) Ph(3-i-Pr,5-Ei) Ph(3-c-Pr,5-OCF₂CF₃) Ph(3-n-Pr,5-OCF₃) Ph(3-i-Pr,5-n-Pr) Ph(3-c-Pr,5-SO₂Me) Ph(3-n-Pr,5-OCHF₂) Ph(3-i-Pr,5-t-Bu) Ph(3-c-Pr,5-TMS) Ph(3-n-Pr,5-OCF₂CF₂H) Ph(3,5-di-i-Pr) Ph(3-c-Pr,5-CN) Ph(3-n-Pr,5-OCF₂CF₃) Ph(3-i-Pr,5-c-Pr) Ph(3-CF₃,5-Cl) Ph(3-n-Pr,5-SO₂Me) Ph(3-i-Pr,5-CF₃) Ph(3-CF₃,5-F) Ph(3-n-Pr,5-TMS) Ph(3-i-Pr,5-CF₂CF₃) Ph(3-CF₃,5-Br) Ph(3-n-Pr,5-CN) Ph(3-i-Pr,5-CF₂CF₂H) Ph(3-CF₃,5-I) Ph(3-t-Bu,5-Cl) Ph(3-i-Pr,5-CF₂H) Ph(3-CF₃,5-Me) Ph(3-t-Bu,5-F) Ph(3-i-Pr,5-OMe) Ph(3-CF₃,5-Ei) Ph(3-t-Bu,5-Br) Ph(3-i-Pr,5-OCF₃) Ph(3-CF₃,5-n-Pr) Ph(3-t-Bu,5-I) Ph(3-i-Pr,5-OCHF₂) Ph(3-CF₃,5-t-Bu) Ph(3-t-Bu,5-Me) Ph(3-i-Pr,5-OCF₂CF₂H) Ph(3-CF₃,5-i-Pr) Ph(3-t-Bu,5-Et) Ph(3-i-Pr,5-OCF₂CF₃) Ph(3-CF₃,5-c-Pr) Ph(3-t-Bu,5-n-Pr) Ph(3-i-Pr,5-SO₂Me) Ph(3,5-di-CF₃) Ph(3,5-di-t-Bu) Ph(3-i-Pr,5-TMS) Ph(3-CF₃,5-CF₂CF₃) Ph(3-t-Bu,5-i-Pr) Ph(3-i-Pr,5-CN) Ph(3-CF₃,5-CF₂CF₂H) Ph(3-t-Bu,5-c-Pr) Ph(3-c-Pr,5-Cl) Ph(3-CF₃,5-CF₂H) Ph(3-t-Bu,5-CF₃) Ph(3-c-Pr,5-F) Ph(3-CF₃,5-OMe) Ph(3-t-Bu,5-CF₂CF₃) Ph(3-c-Pr,5-Br) Ph(3-CF₃,5-OCF₃) Ph(3-CF₃,5-OCHF₂) Ph(3-CF₂CF₂H,5-t-Bu) Ph(3-CF₂H,5-TMS) Ph(3-CF₃,5-OCF₂CF₂H) Ph(3-CF₂CF₂H,5-i-Pr) Ph(3-CF₂H,5-CN) Ph(3-CF₃,5-OCF₂CF₃) Ph(3-CF₂CF₂H,5-c-Pr) Ph(3-OMe,5-Cl) Ph(3-CF₃,5-SO₂Me) Ph(3-CF₂CF₂HCF₃,5-CF₃) Ph(3-OMe,5-F) Ph(3-CF₃,5-IMS) Ph(3-CF₂CF₂H,5-CF₂CF₃) Ph(3-OMe,5-Br) Ph(3-CF₃,5-CN) Ph(3,5-di-CF₂CF₂H) Ph(3-OMe,5-I) Ph(3-CF₂CF₃,5-Cl) Ph(3-CF₂CF₂H,5-CF₂H) Ph(3-OMe,5-Me) Ph(3-CF₂CF₃,5-F) Ph(3-CF₂CF₂H,5-OMe) Ph(3-OMe,5-Ei) Ph(3-CF₂CF₃,5-Br) Ph(3-CF₂CF₂H,5-OCF₃) Ph(3-OMe,5-n-Pr) Ph(3-CF₂CF₃,5-I) Ph(3-CF₂CF₂H,5-OCHF₂) Ph(3-OMe,5-t-Bu) Ph(3-CF₂CF₃,5-Me) Ph(3-CF₂CF₂H,5-OCF₂CF₂H) Ph(3-OMe,5-i-Pr) Ph(3-CF₂CF₃,5-Ei) Ph(3-CF₂CF₂H,5-OCF₂CF₃) Ph(3-OMe,5-c-Pr) Ph(3-CF₂CF₃,5-n-Pr) Ph(3-CF₂CF₂H,5-SO₂Me) Ph(3-OMeCF₃,5-CF₃) Ph(3-CF₂CF₃,5-t-Bu) Ph(3-CF₂CF₂H,5-TMS) Ph(3-OMe,5-CF₂CF₃) Ph(3-CF₂CF₃,5-i-Pr) Ph(3-CF₂CF₂H,5-CN) Ph(3-OMe,5-CF₂CF₂H) Ph(3-CF₂CF₃,5-c-Pr) Ph(3-CF₂H,5-Cl) Ph(3-OMe,5-CF₂H) Ph(3-CF₂CF₃CF₃,5-CF₃) Ph(3-CF₂H,5-F) Ph(3,5-di-OMe) Ph(3,5-di-CF₂CF₃) Ph(3-CF₂H,5-Br) Ph(3-OMe,5-OCF₃) Ph(3-CF₂CF₃,5-CF₂CF₂H) Ph(3-CF₂H,5-I) Ph(3-OMe,5-OCHF₂) Ph(3-CF₂CF₃,5-CF₂H) Ph(3-CF₂H,5-Me) Ph(3-OMe,5-OCF₂CF₂H) Ph(3-CF₂CF₃,5-OMe) Ph(3-CF₂H,5-Ei) Ph(3-OMe,5-OCF₂CF₃) Ph(3-CF₂CF₃,5-OCF₃) Ph(3-CF₂H,5-n-Pr) Ph(3-OMe,5-SO₂Me) Ph(3-CF₂CF₃,5-OCHF₂) Ph(3-CF₂H,5-t-Bu) Ph(3-OMe,5-TMS) Ph(3-CF₂CF₃,5-OCF₂CF₂H) Ph(3-CF₂H,5-i-Pr) Ph(3-OMe,5-CN) Ph(3-CF₂CF₃,5-OCF₂CF₃) Ph(3-CF₂H,5-c-Pr) Ph(3-OCF₃,5-Cl) Ph(3-CF₂CF₃,5-SO₂Me) Ph(3-CF₂H,5-CF₃) Ph(3-OCF₃,5-F) Ph(3-CF₂CF₃,5-TMS) Ph(3-CF₂H,5-CF₂CF₃) Ph(3-OCF₃,5-Br) Ph(3-CF₂CF₃,5-CN) Ph(3-CF₂H,5-CF₂CF₂H) Ph(3-OCF₃,5-I) Ph(3-CF₂CF₂H,5-Cl) Ph(3,5-di-CF₂H) Ph(3-OCF_(3,)5-Me) Ph(3-CF₂CF₂H,5-F) Ph(3-CF₂H,5-OMe) Ph(3-OCF_(3,)5-Ei) Ph(3-CF₂CF₂H,5-Br) Ph(3-CF₂H,5-OCF₃) Ph(3-OCF₃,5-n-Pr) Ph(3-CF₂CF₂H,5-I) Ph(3-CF₂H,5-OCHF₂) Ph(3-OCF₃,5-t-Bu) Ph(3-CF₂CF₂H,5-Me) Ph(3-CF₂H,5-OCF₂CF₂H) Ph(3-OCF₃,5-i-Pr) Ph(3-CF₂CF₂H,5-Ei) Ph(3-CF₂H,5-OCF₂CF₃) Ph(3-OCF₃,5-c-Pr) Ph(3-CF₂CF₂H,5-n-Pr) Ph(3-CF₂H,5-SO₂Me) Ph(3-OCF₃,5-CF₃) Ph(3-OCF₃,5-CF₂CF₃) Ph(3-OCF₂CF₂H,5-Br) Ph(3-OCF₂CF₃,5-OCF₃) Ph(3-OCF₃,5-CF₂CF₂H) Ph(3-OCF₂CF₂H,5-I) Ph(3-OCF₂CF₃,5-OCHF₂) Ph(3-OCF₃,5-CF₂H) Ph(3-OCF₂CF₂H,5-Me) Ph(3-OCF₂CF₃,5-OCF₂CF₂H) Ph(3-OCF₃,5-OMe) Ph(3-OCF₂CF₂H,5-Ei) Ph(3,5-di-OCF₂CF₃) Ph(3,5-di-OCF₃) Ph(3-OCF₂CF₂H,5-n-Pr) Ph(3-OCF₂CF₃,5-SO₂Me) Ph(3-OCF₃,5-OCHF₂) Ph(3-OCF₂CF₂H,5-t-Bu) Ph(3-CF₂CF₃,5-TMS) Ph(3-OCF₃,5-OCF₂CF₂H) Ph(3-OCF₂CF₂H,5-i-Pr) Ph(3-OCF₂CF₃,5-CN) Ph(3-OCF₃,5-OCF₂CF₃) Ph(3-OCF₂CF₂H,5-c-Pr) Ph(3-SO₂Me,5-Cl) Ph(3-OCF₃,5-SO₂Me) Ph(3-OCF₂CF₂HCF₃,5-CF₃) Ph(3-SO₂Me,5-F) Ph(3-OCF₃,5-TMS) Ph(3-OCF₂CF₂H,5-CF₂CF₃) Ph(3-SO₂Me,5-Br) Ph(3-OCF₃,5-CN) Ph(3-OCF₂C₂H,5-CF₂CF₂H) Ph(3-SO₂Me,5-I) Ph(3-OCHF₂,5-Cl) Ph(3-OCF₂CF₂H,5-CF₂H) Ph(3-SO₂Me,5-Me) Ph(3-OCHF₂,5-F) Ph(3-OCF₂CF₂H,5-OMe) Ph(3-SO₂Me,5-Ei) Ph(3-OCHF₂,5-Br) Ph(3-OCF₂CF₂H,5-OCF₃) Ph(3-SO₂Me,5-n-Pr) Ph(3-OCHF₂,5-I) Ph(3-OCF₂CF₂H,5-OCHF₂) Ph(3-SO₂Me,5-t-Bu) Ph(3-OCHF₂,5-Me) Ph(3,5-di-OCF₂CF₂H) Ph(3-SO₂Me,5-i-Pr) Ph(3-OCHF₂,5-Ei) Ph(3-OCF₂CF₂H,5-OCF₂CF₃) Ph(3-SO₂Me,5-c-Pr) Ph(3-OCHF₂,5-n-Pr) Ph(3-OCF₂CF₂H,5-SO₂Me) Ph(3-SO₂MeCF₃,5-CF₃) Ph(3-OCHF₂,5-t-Bu) Ph(3-OCF₂CF₂H,5-TMS) Ph(3-SO₂Me,5-CF₂CF₃) Ph(3-OCHF₂,5-i-Pr) Ph(3-OCF₂CF₂H,5-CN) Ph(3-SO₂Me,5-CF₂CF₂H) Ph(3-OCHF₂,5-c-Pr) Ph(3-OCF₂CF₃,5-Cl) Ph(3-SO₂Me,5-CF₂H) Ph(3-OCHF₂CF₃,5-CF₃) Ph(3-OCF₂CF₃,5-F) Ph(3-SO₂Me,5-OMe) Ph(3-OCF₂CF₃,5-CF₂CF₃) Ph(3-OCF₂CF₃,5-Br) Ph(3-SO₂Me,5-OCF₃) Ph(3-OCHF₂,5-CF₂CF₂H) Ph(3-OCF₂CF₃,5-I) Ph(3-SO₂Me,5-OCHF₂) Ph(3-OCHF₂,5-CF₂H) Ph(3-OCF₂CF₃,5-Me) Ph(3-SO₂Me,5-OCF₂CF₂H) Ph(3-OCHF₂,5-OMe) Ph(3-OCF₂CF₃,5-Ei) Ph(3-SO₂Me,5-OCF₂CF₃) Ph(3-OCHF₂,5-OCF₂) Ph(3-OCF₂CF₃,5-n-Pr) Ph(3,5-di-SO₂Me) Ph(3,5-di-OCHF₂) Ph(3-OCF₂CF₃,5-t-Bu) Ph(3-SO₂Me,5-TMS) Ph(3-OCHF₂,5-OCF₂CF₂H) Ph(3-OCF₂CF₃,5-i-Pr) Ph(3-SO₂Me,5-CN) Ph(3-OCHF₂,5-OCF₂CF₃) Ph(3-OCF₂CF₃,5-c-Pr) Ph(3-TMS,5-Cl) Ph(3-OCHF₂,5-SO₂Me) Ph(3-OCF₂CF₃CF₃,5-CF₃) Ph(3-TMS,5-F) Ph(3-OCHF₂,5-TMS) Ph(3-OCF₂CF₃,5-CF₂CF₃) Ph(3-TMS,5-Br) Ph(3-OCHF₂,5-CN) Ph(3-OCF₂CF₃,5-CF₂CF₂H) Ph(3-TMS,5-I) Ph(3-OCF₂CF₂H,5-Cl) Ph(3-OCF₂CF₃,5-CF₂H) Ph(3-TMS,5-Me) Ph(3-OCF₂CF₂H,5-F) Ph(3-OCF₂CF₃,5-OMe) Ph(3-TMS,5-Ei) Ph(3-TMS,5-n-Pr) Ph(3-CN,5-SO₂Me) Ph(2-Cl,3-F,4-CF₃) Ph(3-TMS,5-t-Bu) Ph(3-CN,5-TMS) Ph(2-Cl,3-F,4-CF₂CF₃) Ph(3-TMS,5-i-Pr) Ph(3,5-di-CN) Ph(2-Cl,3-F,4-CF₂CF₂H) Ph(3-TMS,5-c-Pr) Ph(2,3,4-tri-Cl) Ph(2-Cl,3-F,4-CF₂H) Ph(3-TMS,5-CF₃) Ph(2-Cl,3-Cl,4-F) Ph(2-Cl,3-F,4-OMe) Ph(3-TMS,5-CF₂CF₃) Ph(2-Cl,3-Cl,4-Br) Ph(2-Cl,3-F,4-OCF₃) Ph(3-TMS,5-CF₂CF₂H) Ph(2-Cl,3-Cl,4-I) Ph(2-Cl,3-F,4-OCHF₂) Ph(3-TMS,5-CF₂H) Ph(2-Cl,3-Cl,4-Me) Ph(2-Cl,3-F,4-OCF₂CF₂H) Ph(3-TMS,5-OMe) Ph(2-Cl,3-Cl,4-Et) Ph(2-Cl,3-F,4-OCF₂CF₃) Ph(3-TMS,5-OCF₃) Ph(2-Cl,3-Cl,4-n-Pr) Ph(2-Cl,3-F,4-SO₂Me) Ph(3-TMS,5-OCHF₂) Ph(2-Cl,3-Cl,4-t-Bu) Ph(2-Cl,3-F,4-TMS) Ph(3-TMS,5-OCF₂CF₂H) Ph(2-Cl,3-Cl,4-i-Pr) Ph(2-Cl,3-F,4-CN) Ph(3-TMS,5-OCF₂CF₃) Ph(2-Cl,3-Cl,4-c-Pr) Ph(2-Cl,3-Br,4-Cl) Ph(3-TMS,5-SO₂Me) Ph(2-Cl,3-Cl,4-CF₃) Ph(2-Cl,3-Br,4-F) Ph(3,5-di-TMS) Ph(2-Cl,3-Cl,4-CF₂CF₃) Ph(2-Cl,3,4-di-Br) Ph(3-TMS,5-CN) Ph(2-Cl,3-Cl,4-CF₂CF₂H) Ph(2-Cl,3-Br,4-I) Ph(3-CN,5-Cl) Ph(2-Cl,3-Cl,4-CF₂H) Ph(2-Cl,3-Br,4-Me) Ph(3-CN,5-F) Ph(2-Cl,3-Cl,4-OMe) Ph(2-Cl,3-Br,4-Et) Ph(3-CN,5-Br) Ph(2-Cl,3-Cl,4-OCF₃) Ph(2-Cl,3-Br,4-n-Pr) Ph(3-CN,5-I) Ph(2-Cl,3-Cl,4-OCHF₂) Ph(2-Cl,3-Br,4-t-Bu) Ph(3-CN,5-Me) Ph(2-Cl,3-Cl,4-OCF₂CH₂H) Ph(2-Cl,3-Br,4-i-Pr) Ph(3-CN,5-Ei) Ph(2-Cl,3-Cl,4-OCF₂CF₃) Ph(2-Cl,3-Br,4-c-Pr) Ph(3-CN,5-n-Pr) Ph(2-Cl,3-Cl,4-SO₂Me) Ph(2-Cl,3-Br,4-CF₃) Ph(3-CN,5-t-Bu) Ph(2-Cl,3-Cl,4-TMS) Ph(2-Cl,3-Br,4-CF₂CF₃) Ph(3-CN,5-i-Pr) Ph(2-Cl,3-Cl,4-CN) Ph(2-Cl,3-Br,4-CF₂CF₂H) Ph(3-CN,5-c-Pr) Ph(2-Cl,3-F,4-Cl) Ph(2-Cl,3-Br,4-CF₂H) Ph(3-CN,5-CF₃) Ph(2-Cl,3,4-di-F) Ph(2-Cl,3-Br,4-OMe) Ph(3-CN,5-CF₂CF₃) Ph(2-Cl,3-F,4-Br) Ph(2-Cl,3-Br,4-OCF₃) Ph(3-CN,5-CF₂CF₂H) Ph(2-Cl,3-F,4-I) Ph(2-Cl,3-Br,4-OCHF₂) Ph(3-CN,5-CF₂H) Ph(2-Cl,3-F,4-Me) Ph(2-Cl,3-Br,4-OCF₂CF₂H) Ph(3-CN,5-OMe) Ph(2-Cl,3-F,4-Et) Ph(2-Cl,3-Br,4-OCF₂CF₃) Ph(3-CN,5-OCF₃) Ph(2-Cl,3-F,4-n-Pr) Ph(2-Cl,3-Br,4-SO₂Me) Ph(3-CN,5-OCHF₂) Ph(2-Cl,3-F,4-t-Bu) Ph(2-Cl,3-Br,4-TMS) Ph(3-CN,5-OCF₂CF₂H) Ph(2-Cl,3-F,4-i-Pr) Ph(2-Cl,3-Br,4-CN) Ph(3-CN,5-OCF₂CF₃) Ph(2-Cl,3-F,4-c-Pr) Ph(2-Cl,3-I,4-Cl) Ph(2-Cl,3-I,4-F) Ph(2-Cl,3-Me,4-OMe) Ph(2-Cl,3-n-Pr,4-Et) Ph(2-Cl,3-I,4-Br) Ph(2-Cl,3-Me,4-OCFH₃) Ph(2-Cl,3,4-di-n-Pr) Ph(2-Cl,3,4-di-I) Ph(2-Cl,3-Me,4-OCHF₂) Ph(2-Cl,3-n-Pr,4-t-Bu) Ph(2-Cl,3-I,4-Me) Ph(2-Cl,3-Me,4-OCF₂CF₂H) Ph(2-Cl,3-n-Pr,4-i-Pr) Ph(2-Cl,3-I,4-Et) Ph(2-Cl,3-Me,4-OCF₂CF₃) Ph(2-Cl,3-n-Pr,4-c-Pr) Ph(2-Cl,3-I,4-n-Pr) Ph(2-Cl,3-Me,4-SO₂Me) Ph(2-Cl,3-n-Pr,4-CF₃) Ph(2-Cl,3-I,4-t-Bu) Ph(2-Cl,3-Me,4-TMS) Ph(2-Cl,3-n-Pr,4-CF₂CF₃) Ph(2-Cl,3-I,4-i-Pr) Ph(2-Cl,3-Me,4-CN) Ph(2-Cl,3-n-Pr,4-CF₂CF₂H) Ph(2-Cl,3-I,4-c-Pr) Ph(2-Cl,3-Et,4-Cl) Ph(2-Cl,3-n-Pr,4-CF₂H) Ph(2-Cl,3-I,4-CF₃) Ph(2-Cl,3-Et,4-F) Ph(2-Cl,3-n-Pr,4-OMe) Ph(2-Cl,3-I,4-CF₂CF₃) Ph(2-Cl,3-Et,4-Br) Ph(2-Cl,3-n-Pr,4-OCF₃) Ph(2-Cl,3-I,4-CF₂CF₂H) Ph(2-Cl,3-Et,4-I) Ph(2-Cl,3-n-Pr,4-OCHF₂) Ph(2-Cl,3-I,4-CF₂H) Ph(2-Cl,3-Et,4-Me) Ph(2-Cl,3-n-Pr,4-OCF₂CF₂H) Ph(2-Cl,3-I,4-OMe) Ph(2-Cl,3,4-di-Et) Ph(2-Cl,3-n-Pr,4-OCF₂CF₃) Ph(2-Cl,3-I,4-OCF₃) Ph(2-Cl,3-Et,4-n-Pr) Ph(2-Cl,3-n-Pr,4-SO₂Me) Ph(2-Cl,3-I,4-OCHF₂) Ph(2-Cl,3-Et,4-t-Bu) Ph(2-Cl,3-n-Pr,4-TMS) Ph(2-Cl,3-I,4-OCF₂CF₂H) Ph(2-Cl,3-Et,4-i-Pr) Ph(2-Cl,3-n-Pr,4-CN) Ph(2-Cl,3-I,4-OCF₂CF₃) Ph(2-Cl,3-Et,4-c-Pr) Ph(2-Cl,3-t-Bu,4-Cl) Ph(2-Cl,3-I,4-SO₂Me) Ph(2-Cl,3-Et,4-CF₃) Ph(2-Cl,3-t-Bu,4-F) Ph(2-Cl,3-I,4-TMS) Ph(2-Cl,3-Et,4-CF₂CF₃) Ph(2-Cl,3-t-Bu,4-Br) Ph(2-Cl,3-I,4-CN) Ph(2-Cl,3-Et,4-CF₂Cg₂H) Ph(2-Cl,3-t-Bu,4-I) Ph(2-Cl,3-Me,4-Cl) Ph(2-Cl,3-Et,4-CF₂H) Ph(2-Cl,3-t-Bu,4-Me) Ph(2-Cl,3-Me,4-F) Ph(2-Cl,3-Et,4-OMe) Ph(2-Cl,3-t-Bu,4-Et) Ph(2-Cl,3-Me,4-Br) Ph(2-Cl,3-Et,4-OCF₃) Ph(2-Cl,3-t-Bu,4-n-Pr) Ph(2-Cl,3-Me,4-I) Ph(2-Cl,3-Et,4-OCHF₂) Ph(2-Cl,3,4-di-t-Bu) Ph(2-Cl,3,4-di-Me) Ph(2-Cl,3-Et,4-OCF₂CF₂H) Ph(2-Cl,3-t-Bu,4-i-Pr) Ph(2-Cl,3-Me,4-Et) Ph(2-Cl,3-Et,4-OCF₂CF₃) Ph(2-Cl,3-t-Bu,4-c-Pr) Ph(2-Cl,3-Me,4-n-Pr) Ph(2-Cl,3-Et,4-SO₂Me) Ph(2-Cl,3-t-Bu,4-CF₃) Ph(2-Cl,3-Me,4-t-Bu) Ph(2-Cl,3-Et,4-TMS) Ph(2-Cl,3-t-Bu,4-CF₂CF₃) Ph(2-Cl,3-Me,4-i-Pr) Ph(2-Cl,3-Et,4-CN) Ph(2-Cl,3-t-Bu,4-CF₂CF₂H) Ph(2-Cl,3-Me,4-c-Pr) Ph(2-Cl,3-n-Pr,4-Cl) Ph(2-Cl,3-t-Bu,4-CF₂H) Ph(2-Cl,3-Me,4-CF₃) Ph(2-Cl,3-n-Pr,4-F) Ph(2-Cl,3-t-Bu,4-OMe) Ph(2-Cl,3-Me,4-CF₂CF₃) Ph(2-Cl,3-n-Pr,4-Br) Ph(2-Cl,3-t-Bu,4-OCF) Ph(2-Cl,3-Me,4-CF₂CF₂H) Ph(2-Cl,3-n-Pr,4-I) Ph(2-Cl,3-t-Bu,4-OCHF₂) Ph(2-Cl,3-Me,4-CF₂H) Ph(2-Cl,3-n-Pr,4-Me) Ph(2-Cl,3-t-Bu,4-OCF₂CF₂H) Ph(2-Cl,3-t-Bu,4-OCF₂CF₃) Ph(2-Cl,3,4-di-c-Pr) Ph(2-Cl,3-CF₂CF₃,4-Cl) Ph(2-Cl,3-t-Bu,4-SO₂Me) Ph(2-Cl,3-c-Pr,4-CF₃) Ph(2-Cl,3-CF₂CF₃,4-F) Ph(2-Cl,3-t-Bu,4-TMS) Ph(2-Cl,3-c-Pr,4-CF₂CF₃) Ph(2-Cl,3-CF₂CF₃,4-Br) Ph(2-Cl,3-t-Bu,4-CN) Ph(2-Cl,3-c-Pr,4-CF₂CF₂H) Ph(2-Cl,3-CF₂CF₃,4-I) Ph(2-Cl,3-i-Pr,4-Cl) Ph(2-Cl,3-c-Pr,4-CF₂H) Ph(2-Cl,3-CF₂CF₃,4-Me) Ph(2-Cl,3-i-Pr,4-F) Ph(2-Cl,3-c-Pr,4-OMe) Ph(2-Cl,3-CF₂CF₃,4-Ei) Ph(2-Cl,3-i-Pr,4-Br) Ph(2-Cl,3-c-Pr,4-OCF₃) Ph(2-Cl,3-CF₂CF₃,4-n-Pr) Ph(2-Cl,3-i-Pr,4-I) Ph(2-Cl,3-c-Pr,4-OCHF₂) Ph(2-Cl,3-CF₂CF₃,4-t-Bu) Ph(2-Cl,3-i-Pr,4-Me) Ph(2-Cl,3-c-Pr,4-OCF₂CF₂H) Ph(2-Cl,3-CF₂CF₃,4-i-Pr) Ph(2-Cl,3-i-Pr,4-Ei) Ph(2-Cl,3-c-Pr,4-OCF₂CF₃) Ph(2-Cl,3-CF₂CF₃,4-c-Pr) Ph(2-Cl,3-i-Pr,4-n-Pr) Ph(2-Cl,3-c-Pr,4-SO₂Me) Ph(2-Cl,3-CF₂CF₃CF₃,4-CF₃) Ph(2-Cl,3-i-Pr,4-t-Bu) Ph(2-Cl,3-c-Pr,4-TMS) Ph(2-Cl,3,4-di-CF₂CF₃) Ph(2-Cl,3,4-di-i-Pr) Ph(2-Cl,3-c-Pr,4-CN) Ph(2-Cl,3-CF₂CF₃,4-CF₂CF₂H) Ph(2-Cl,3-i-Pr,4-c-Pr) Ph(2-Cl,3-CF₃,4-Cl) Ph(2-Cl,3-CF₂CF₃,4-CF₂H) Ph(2-Cl,3-i-Pr,4-CF₃) Ph(2-Cl,3-CF₃,4-F) Ph(2-Cl,3-CF₂CF₃,4-OMe) Ph(2-Cl,3-i-Pr,4-CF₂CF₃) Ph(2-Cl,3-CF₃,4-Br) Ph(2-Cl,3-CF₂CF₃, 4-OCF₃) Ph(2-Cl,3-i-Pr,4-CF₂CF₂H) Ph(2-Cl,3-CF₃,4-I) Ph(2-Cl,3-CF₂CF₃,4-OCHF₂) Ph(2-Cl,3-i-Pr,4-CF₂H) Ph(2-Cl,3-CF₃,4-Me) Ph(2-Cl,3-CF₂CF₃,4-OCF₂CF₂H) Ph(2-Cl,3-i-Pr,4-OMe) Ph(2-Cl,3-CF₃,4-Ei) Ph(2-Cl,3-CF₂CF₃,4-OCF₂CF₃) Ph(2-Cl,3-i-Pr,4-OCF₃) Ph(2-Cl,3-CF₃,4-n-Pr) Ph(2-Cl,3-CF₂CF₃,4-SO₂Me) Ph(2-Cl,3-i-Pr,4-OCHF₂) Ph(2-Cl,3-CF₃,4-t-Bu) Ph(2-Cl,3-CF₂CF₃,4-TMS) Ph(2-Cl,3-i-Pr,4-OCF₂CF₃) Ph(2-Cl,3-CF₃,4-i-Pr) Ph(2-Cl,3-CF₂CF₃,4-CN) Ph(2-Cl,3-i-Pr,4-OCF₂CF₃H) Ph(2-Cl,3-CF₃,4-c-Pr) Ph(2-Cl,3-CF₂CF₂H, 4-Cl) Ph(2-Cl,3-i-Pr,4-SO₂Me) Ph(2-Cl,3,4-di-CF₃) Ph(2-Cl,3-CF₂CF₂H, 4-F) Ph(2-Cl,3-i-Pr,4-TMS) Ph(2-Cl,3-CF₃,4-CF₂CF₃) Ph(2-Cl,3-CF₂CF₂H, 4-Br) Ph(2-Cl,3-i-Pr,4-CN) Ph(2-Cl,3-CF₃,4-CF₂CF₂H) Ph(2-Cl,3-CF₂CF₂H, 4-I) Ph(2-Cl,3-c-Pr,4-Cl) Ph(2-Cl,3-CF₃,4-CF₂H) Ph(2-Cl,3-CF₂CF₂H, 4-Me) Ph(2-Cl,3-c-Pr,4-F) Ph(2-Cl,3-CF₃,4-OMe) Ph(2-Cl,3-CF₂CF₂H, 4-Ei) Ph(2-Cl,3-c-Pr,4-Br) Ph(2-Cl,3-CF₃,4-OCF₃) Ph(2-Cl,3-CF₂CF₂H, 4-n-Pr) Ph(2-Cl,3-c-Pr,4-I) Ph(2-Cl,3-CF₃,4-OCHF₂) Ph(2-Cl,3-CF₂CF₂H, 4-t-Bu) Ph(2-Cl,3-c-Pr,4-Me) Ph(2-Cl,3-CF₃,4-OCF₂CF₂H) Ph(2-Cl,3-CF₂CF₂H, 4-i-Pr) Ph(2-Cl,3-c-Pr,4-Ei) Ph(2-Cl,3-CF₃,4-OCF₂CF₃) Ph(2-Cl,3-CF₂CF₂H, 4-c-Pr) Ph(2-Cl,3-c-Pr,4-n-Pr) Ph(2-Cl,3-CF₃,4-SO₂Me) Ph(2-Cl,3-CF₂CF₂HCF₃, 4-CF₃) Ph(2-Cl,3-c-Pr,4-t-Bu) Ph(2-Cl,3-CF₃,4-IMS) Ph(2-C,3-CF₂CF₂H,4-CF₂CF₃) Ph(2-Cl,3-c-Pr,4-i-Pr) Ph(2-Cl,3-CF₃,4-CN) Ph(2-Cl,3,4-di-CF₂CF₂H) Ph(2-Cl,3-CF₂CF₂H,4-CF₂H) Ph(2-Cl,3-OMe,4-Me) Ph(2-Cl,3-OCF₃,4-OCF₂CF₂H) Ph(2-Cl,3-CF₂CF₂H,4-OMe) Ph(2-Cl,3-OMe,4-Ei) Ph(2-Cl,3-OCF₃,4-OCF₂CF₃) Ph(2-Cl,3-CF₂CF₂H,4-OCF₃) Ph(2-Cl,3-OMe,4-n-Pr) Ph(2-Cl,3-OCF₃,4-SO₂Me) Ph(2-Cl,3-CF₂CF₂H,4-OCHF₂) Ph(2-Cl,3-OMe,4-t-Bu) Ph(2-Cl,3-OCF₃,4-TMS) Ph(2-Cl,3-CF₂CF₂H,4-OCF₂CF₂H) Ph(2-Cl,3-OMe,4-i-Pr) Ph(2-Cl,3-OCF₃,4-CN) Ph(2-Cl,3-CF₂CF₂H,4-OCF₂CF₃) Ph(2-Cl,3-OMe,4-c-Pr) Ph(2-Cl,3-OCHF₂,4-Cl) Ph(2-Cl,3-CF₂CF₂H, 4-SO₂Me) Ph(2-Cl,3-OMeCF₃,4-CF₃) Ph(2-Cl,3-OCHF₂,4-F) Ph(2-Cl,3-CF₂CF₂H,4-TMS) Ph(2-Cl,3-OMe,4-CF₂CF₃) Ph(2-Cl,3-OCHF₂,4-Br) Ph(2-Cl,3-CF₂CF₂H,4-CN) Ph(2-Cl,3-OMe,4-CF₂CF₂H) Ph(2-Cl,3-OCHF₂,4-I) Ph(2-Cl,3-CF₂H,4-Cl) Ph(2-Cl,3-OMe,4-CF₂H) Ph(2-Cl,3-OCHF₂,4-Me) Ph(2-Cl,3-CF₂H,4-F) Ph(2-Cl,3,4-di-OMe) Ph(2-Cl,3-OCHF₂,4-Ei) Ph(2-Cl,3-CF₂H,4-Br) Ph(2-Cl,3-OMe,4-OCF₃) Ph(2-Cl,3-OCHF₂,4-n-Pr) Ph(2-Cl,3-CF₂H,4-I) Ph(2-Cl,3-OMe,4-OCHF₂) Ph(2-Cl,3-OCHF₂,4-t-Bu) Ph(2-Cl,3-CF₂H,4-Me) Ph(2-Cl,3-OMe,4-OCF₂CF₂H) Ph(2-Cl,3-OCHF₂,4-i-Pr) Ph(2-Cl,3-CF₂H,4-Ei) Ph(2-Cl,3-OMe,4-OCF₂CF₃) Ph(2-Cl,3-OCHF₂,4-c-Pr) Ph(2-Cl,3-CF₂H,4-n-Pr) Ph(2-Cl,3-OMe,4-SO₂Me) Ph(2-Cl,3-OCHF₂CF₃,4-CF₃) Ph(2-Cl,3-CF₂H,4-t-Bu) Ph(2-Cl,3-OMe,4-TMS) Ph(2-Cl,3-OCF₂CF₃,4-CF₂CF₃) Ph(2-Cl,3-CF₂H,4-i-Pr) Ph(2-Cl,3-OMe,4-CN) Ph(2-Cl,3-OCHF₂CF₃,4-CF₃) Ph(2-Cl,3-CF₂H,4-c-Pr) Ph(2-Cl,3-OCF₃,4-C1) Ph(2-Cl,3-OCHF₂,4-CF₂H) Ph(2-Cl,3-CF₂H,4-CF₃) Ph(2-Cl,3-OCF₃,4-F) Ph(2-Cl,3-OCHF₂,4-OMe) Ph(2-Cl,3-CF₂H,4-CF₂CF₃) Ph(2-Cl,3-OCF₃,4-Br) Ph(2-Cl,3-OCHF₂,4-OCF₃) Ph(2-Cl,3-CF₂H,4-CF₂CF₂H) Ph(2-Cl,3-OCF₃,4-I) Ph(2-Cl,3,4-di-OCHF₂) Ph(2-Cl,3,4-di-CF₂H) Ph(2-Cl,3-OCF₃,4-Me) Ph(2-Cl,3-OCHF₂,4-OCF₂CF₂H) Ph(2-Cl,3-CF₂H,4-OMe) Ph(2-Cl,3-OCF₃,4-Ei) Ph(2-Cl,3-OCHF₂,4-OCF₂CF₃) Ph(2-Cl,3-CF₂H,4-OCF₃) Ph(2-Cl,3-OCF₃,4-n-Pr) Ph(2-Cl,3-OCHF₂,4-SO₂Me) Ph(2-Cl,3-CF₂H,4-OCHF₂) Ph(2-Cl,3-OCF₃,4-t-Bu) Ph(2-Cl,3-OCHF₂,4-TMS) Ph(2-Cl,3-CF₂H,4-OCF₂CF₂H) Ph(2-Cl,3-OCF₃,4-i-Pr) Ph(2-Cl,3-OCHF₂,4-CN) Ph(2-Cl,3-CF₂H,4-OCF₂CF₃) Ph(2-Cl,3-OCF₃,4-c-Pr) Ph(2-Cl,3-OCF₂CF₂H,4-C1) Ph(2-Cl,3-CF₂H,4-SO₂Me) Ph(2-Cl,3-OCF₃,4-CF₃) Ph(2-C1,3-OCF₂CF₂H,4-F) Ph(2-Cl,3-CF₂H,4-TMS) Ph(2-Cl,3-OCF₃,4-CF₂CF₃) Ph(2-Cl,3-OCF₂CF₂H,4-Br) Ph(2-Cl,3-CF₂H,4-CN) Ph(2-Cl,3-OCF₃,4-CF₂CF₂H) Ph(2-Cl,3-OCF₂CF₂H,4-I) Ph(2-Cl,3-OMe,4-Cl) Ph(2-Cl,3-OCF₃,4-CF₂H) Ph(2-Cl,3-OCF₂CF₂H,4-Me) Ph(2-Cl,3-OMe,4-F) Ph(2-Cl,3-OCF₃,4-OMe) Ph(2-Cl,3-OCF₂CF₂H,4-Ei) Ph(2-Cl,3-OMe,4-Br) Ph(2-Cl,3,4-di-OCF₃) Ph(2-Cl,3-OCF₂CF₂H,4-n-Pr) Ph(2-Cl,3-OMe,4-I) Ph(2-Cl,3-OCF₃,4-OCHF₂) Ph(2-Cl,3OCF₂CF₂H,4-t-Bu) Ph(2-Cl,3-OCF₂CF₂H,4-i-Pr) Ph(2-Cl,3-OCF₂CF₃,4-CN) Ph(2-Cl,3-TMS,4-CF₂CF₂H) Ph(2-Cl,3-OCF₂CF₂H,4-c-Pr) Ph(2-Cl,3-SO₂Me,4-Cl) Ph(2-Cl,3-TMS,4-CF₂H) Ph(2-Cl,3-OCF₂CF₂HCF₃,4-CF₃) Ph(2-Cl,3-SO₂Me,4-F) Ph(2-Cl,3-TMS,4-OMe) Ph(2-Cl,3-OCF₂CF₂H,4-CF₂CF₃) Ph(2-Cl,3-SO₂Me,4-Br) Ph(2-Cl,3-TMS,4-OCF₃) Ph(2-Cl,3-OCF₂CF₂H,4-CF₂CF₂H) Ph(2-Cl,3-SO₂Me,4-I) Ph(2-Cl,3-TMS,4-OCHF₂) Ph(2-Cl,3-OCF₂CF₂H,4-CF₂H) Ph(2-Cl,3-SO₂Me,4-Me) Ph(2-Cl,3-TMS,4-OCF₂CF₂H) Ph(2-C1,3-OCF₂CF₂H,4-OMe) Ph(2-Cl,3-SO₂Me,4-Ei) Ph(2-Cl,3-TMS,4-OCF₂CF₃) Ph(2-Cl,3-OCF₂CF₂H,4-OCF₃) Ph(2-Cl,3-SO₂Me,4-n-Pr) Ph(2-Cl,3-TMS,4-SO₂Me) Ph(2-Cl,3-OCF₂CF₂H,4-OCHF₂) Ph(2-Cl,3-SO₂Me,4-t-Bu) Ph(2-Cl,3,4-di-TMS) Ph(2-Cl,3,4-di-OCF₂CF₂H) Ph(2-Cl,3-SO₂Me,4-i-Pr) Ph(2-Cl,3-TMS,4-CN) Ph(2-Cl,3-OCF₂CF₂H,4-OCF₂CF₃) Ph(2-Cl,3-SO₂Me,4-c-Pr) Ph(2-Cl,3-CN,4-Cl) Ph(2-Cl,3-OCF₂CF₂H,4-SO₂Me) Ph(2-Cl,3-SO₂MeCF₃,4-CF₃) Ph(2-Cl,3-CN,4-F) Ph(2-Cl,3-OCF₂CF₂H,4-TMS) Ph(2-Cl,3-SO₂Me,4-CF₂CF₃) Ph(2-Cl,3-CN,4-Br) Ph(2-Cl,3-OCF₂CF₂H,4-CN) Ph(2-Cl,3-SO₂Me,4-CF₂CF₂H) Ph(2-Cl,3-CN,4-I) Ph(2-Cl,3-OCF₂CF₃,4-Cl) Ph(2-Cl,3-SO₂Me,4-CF₂H) Ph(2-Cl,3-CN,4-Me) Ph(2-Cl,3-OCF₂CF₃,4-F) Ph(2-Cl,3-SO₂Me,4-OMe) Ph(2-Cl,3-CN,4-Ei) Ph(2-Cl,3-OCF₂CF₃,4-Br) Ph(2-Cl,3-SO₂Me,4-OCF₃) Ph(2-Cl,3-CN,4-n-Pr) Ph(2-Cl,3-OCF₂CF₃,4-I) Ph(2-Cl,3-SO₂Me,4-OCHF₂) Ph(2-Cl,3-CN,4-t-Bu) Ph(2-Cl,3-OCF₂CF₃,4-Me) Ph(2-Cl,3-SO₂Me,4-OCF₂CF₂H) Ph(2-Cl,3-CN,4-i-Pr) Ph(2-Cl,3-OCF₂CF₃,4-Ei) Ph(2-Cl,3-SO₂Me,4-OCF₂CF₃) Ph(2-Cl,3-CN,4-c-Pr) Ph(2-Cl,3-OCF₂CF₃,4-n-Pr) Ph(2-Cl,3,4-di-SO₂Me) Ph(2-Cl,3-CN,4-CF₃) Ph(2-Cl,3-OCF₂CF₃,4-t-Bu) Ph(2-Cl,3-SO₂Me,4-TMS) Ph(2-Cl,3-CN,4-CF₂CF₃) Ph(2-Cl,3-OCF₂CF₃,4-i-Pr) Ph(2-Cl,3-SO₂Me,4-CN) Ph(2-Cl,3-CN,4-CF₂CF₂H) Ph(2-Cl,3-OCF₂CF₃,4-c-Pr) Ph(2-Cl,3-TMS,4-Cl) Ph(2-Cl,3-CN,4-CF₂H) Ph(2-Cl,3-OCF₂CF₃CF₃,4-CF₃) Ph(2-Cl,3-TMS,4-F) Ph(2-Cl,3-CN,4-OMe) Ph(2-Cl,3-OCF₂CF₃,4-CF₂CF₃) Ph(2-Cl,3-TMS,4-Br) Ph(2-Cl,3-CN,4-OCF₃) Ph(2-Cl,3-OCF₂CF₃,4-CF₂CF₂H) Ph(2-Cl,3-TMS,4-I) Ph(2-Cl,3-CN,4-OCHF₂) Ph(2-Cl,3-OCF₂CF₃,4-CF₂H) Ph(2-Cl,3-TMS,4-Me) Ph(2-Cl,3-CN,4-OCF₂CF₂H) Ph(2-Cl,3-OCF₂CF₃,4-OMe) Ph(2-Cl,3-TMS,4-Ei) Ph(2-Cl,3-CN,4-OCF₂CF₃) Ph(2-Cl,3-OCF₂CF₃,4-OCF₃) Ph(2-Cl,3-TMS,4-n-Pr) Ph(2-Cl,3-CN,4-SO₂Me) Ph(2-Cl,3-OCF₂CF₃,4-OCHF₂) Ph(2-Cl,3-TMS,4-t-Bu) Ph(2-Cl,3-CN,4-TMS) Ph(2-Cl,3-OCF₂CF₃,4-OCF₂CF₂H) Ph(2-Cl,3-TMS,4-i-Pr) Ph(2-Cl,3,4-di-CN) Ph(2-Cl,3,4-di-OCF₂CF₃) Ph(2-Cl,3-TMS,4-c-Pr) Ph(2,3,5-tri-Cl) Ph(2-Cl,3-OCF₂CF₃,4-SO₂Me) Ph(2-Cl,3-TMS,4-CF₃) Ph(2-Cl,3-Cl,5-F) Ph(2-Cl,3-OCF₂CF₃,4-TMS) Ph(2-Cl,3-TMS,4-CF₂CF₃) Ph(2-Cl,3-Cl,5-Br) Ph(2-Cl,3-Cl,5-I) Ph(2-Cl,3-F,5-OCHF₂) Ph(2-Cl,3-I,5-t-Bu) Ph(2-Cl,3-Cl,5-Me) Ph(2-Cl,3-F,5-OCF₂CF₂H) Ph(2-Cl,3-I,-i-Pr) Ph(2-Cl,3-Cl,5-Et) Ph(2-Cl,3-F,5-OCF₂CF₃) Ph(2-Cl,3-I,5-c-Pr) Ph(2-Cl,3-Cl,5-n-Pr) Ph(2-Cl,3-F,5-SO₂Me) Ph(2-Cl,3-I,5-CF₃) Ph(2-Cl,3-Cl,5-t-Bu) Ph(2-Cl,3-F,5-TMS) Ph(2-Cl,3-I,5-CF₂CF₃) Ph(2-Cl,3-Cl,5-i-Pr) Ph(2-Cl,3-F,5-CN) Ph(2-Cl,3-I,5-CF₂CF₂H) Ph(2-Cl,3-Cl,5-c-Pr) Ph(2-Cl,3-Br,5-Cl) Ph(2-Cl,3-I,5-CF₂H) Ph(2-Cl,3-Cl,5-CF₃) Ph(2-Cl,3-Br,5-F) Ph(2-Cl,3-I,5-OMe) Ph(2-Cl,3-Cl,5-CF₂CF₃) Ph(2-Cl,3,5-di-Br) Ph(2-Cl,3-I,5-OCF₃) Ph(2-Cl,3-Cl,5-CF₂CF₂H) Ph(2-Cl,3-Br,5-I) Ph(2-Cl,3-I,5-OCHF₂) Ph(2-Cl,3-Cl,5-CF₂H) Ph(2-Cl,3-Br,5-Me) Ph(2-Cl,3-I,5-OCF₂CF₂H) Ph(2-Cl,3-Cl,5-OMe) Ph(2-Cl,3-Br,5-Et) Ph(2-Cl,3-I,5-OCF₂CF₃) Ph(2-Cl,3-Cl,5-OCF₃) Ph(2-Cl,3-Br,5-n-Pr) Ph(2-Cl,3-I,5-SO₂Me) Ph(2-Cl,3-Cl,5-OCHF₂) Ph(2-Cl,3-Br,5-t-Bu) Ph(2-Cl,3-I,5-TMS) Ph(2-Cl,3-Cl,5-OCF₂CF₂H) Ph(2-Cl,3-Br,5-i-Pr) Ph(2-Cl,3-I,5-CN) Ph(2-Cl,3-Cl,5-OCF₂CF₃) Ph(2-Cl,3-Br,5-c-Pr) Ph(2-Cl,3-Me,5-Cl) Ph(2-Cl,3-Cl,5-SO₂Me) Ph(2-Cl,3-Br,5-CF₃) Ph(2-Cl,3-Me,5-F) Ph(2-Cl,3-Cl,5-TMS) Ph(2-Cl,3-Br,5-CF₂CF₃) Ph(2-Cl,3-Me,5-Br) Ph(2-Cl,3-Cl,5-CN) Ph(2-Cl,3-Br,5-CF₂CF₂H) Ph(2-Cl,3-Me,5-I) Ph(2-Cl,3-F,5-Cl) Ph(2-Cl,3-Br,5-CF₂H) Ph(2-Cl,3,5-di-Me) Ph(2-Cl,3,5-di-F) Ph(2-Cl,3-Br,5-OMe) Ph(2-Cl,3-Me,5-Et) Ph(2-Cl,3-F,5-Br) Ph(2-Cl,3-Br,5-OCF₃) Ph(2-Cl,3-Me,5-n-Pr) Ph(2-Cl,3-F,5-I) Ph(2-Cl,3-Br,5-OCHF₂) Ph(2-Cl,3-Me,5-t-Bu) Ph(2-Cl,3-F,5-Me) Ph(2-Cl,3-Br,5-OCF₂CF₂H) Ph(2-Cl,3-Me,5-i-Pr) Ph(2-Cl,3-F,5-Et) Ph(2-Cl,3-Br,5-OCF₂CF₃) Ph(2-Cl,3-Me,5-c-Pr) Ph(2-Cl,3-F,5-n-Pr) Ph(2-Cl,3-Br,5-SO₂Me) Ph(2-Cl,3-Me,5-CF₃) Ph(2-Cl,3-F,5-t-Bu) Ph(2-Cl,3-Br,5-TMS) Ph(2-Cl,3-Me,5-CF₂CF₃) Ph(2-Cl,3-F,5-i-Pr) Ph(2-Cl,3-Br,5-CN) Ph(2-Cl,3-Me,5-CF₂CF₂H) Ph(2-Cl,3-F,5-c-Pr) Ph(2-Cl,34,5-Cl) Ph(2-Cl,3-Me,5-CF₂H) Ph(2-Cl,3-F,5-CF₃) Ph(2-Cl,34,5-F) Ph(2-Cl,3-Me,5-OMe) Ph(2-Cl,3-F,5-CF₂CF₃) Ph(2-Cl,34,5-Br) Ph(2-Cl,3-Me,5-OCF₃) Ph(2-Cl,3-F,5-CF₂CF₂H) Ph(2-Cl,3,5-di-I) Ph(2-Cl,3-Me,5-OCHF₂) Ph(2-Cl,3-F,5-CF₂H) Ph(2-Cl,34,5-Me) Ph(2-Cl,3-Me,5-OCF₂CF₂H) Ph(2-Cl,3-F,5-OMe) Ph(2-Cl,34,5-Et) Ph(2-Cl,3-Me,5-OCF₂CF₃) Ph(2-Cl,3-F,5-OCF₃) Ph(2-Cl,3-I,5-n-Pr) Ph(2-Cl,3-Me,5-SO₂Me) Ph(2-Cl,3-Me,5-TMS) Ph(2-Cl,3-n-Pr,5-CF₂CF₃) Ph(2-Cl,3-i-Pr,5-Br) Ph(2-Cl,3-Me,5-CN) Ph(2-Cl,3-n-Pr,5-CF₂CF₂H) Ph(2-Cl,3-i-Pr,5-I) Ph(2-Cl,3-Et,5-Cl) Ph(2-Cl,3-n-Pr,5-CF₂H) Ph(2-Cl,3-i-Pr,5-Me) Ph(2-Cl,3-Et,5-F) Ph(2-Cl,3-n-Pr,5-OMe) Ph(2-Cl,3-i-Pr,5-Ei) Ph(2-Cl,3-Et,5-Br) Ph(2-Cl,3-n-Pr,5-OCF₃) Ph(2-Cl,3-i-Pr,5-n-Pr) Ph(2-Cl,3-Et,5-I) Ph(2-Cl,3-n-Pr,5-OCHF₂) Ph(2-Cl,3-i-Pr,5-t-Bu) Ph(2-Cl,3-Et,5-Me) Ph(2-Cl,3-n-Pr,5-OCF₂CF₂H) Ph(2-Cl,3,5-di-i-Pr) Ph(2-Cl,3,5-di-Et) Ph(2-Cl,3-n-Pr,5-OCF₂CF₃) Ph(2-Cl,3-i-Pr,5-c-Pr) Ph(2-Cl,3-Et,5-n-Pr) Ph(2-Cl,3-n-Pr,5-SO₂Me) Ph(2-Cl,3-i-Pr,5-CF₃) Ph(2-Cl,3-Et,5-t-Bu) Ph(2-Cl,3-n-Pr,5-TMS) Ph(2-Cl,3-i-Pr,5-CF₂CF₃) Ph(2-Cl,3-Et,5-i-Pr) Ph(2-Cl,3-n-Pr,5-CN) Ph(2-Cl,3-i-Pr,5-CF₂CF₂H) Ph(2-Cl,3-Et,5-c-Pr) Ph(2-Cl,3-t-Bu,5-Cl) Ph(2-Cl,3-i-Pr,5-CF₂H) Ph(2-Cl,3-Et,5-CF₃) Ph(2-Cl,3-t-Bu,5-F) Ph(2-Cl,3-i-Pr,5-OMe) Ph(2-Cl,3-Et,5-CF₂CF₃) Ph(2-Cl,3-t-Bu,5-Br) Ph(2-Cl,3-i-Pr,5-OCF₃) Ph(2-Cl,3-Et,5-CF₂CF₂H) Ph(2-Cl,3-t-Bu,5-I) Ph(2-Cl,3-i-Pr,5-OCHF₂) Ph(2-Cl,3-Et,5-CF₂H) Ph(2-Cl,3-t-Bu,5-Me) Ph(2-Cl,3-i-Pr,5-OCF₂CF₂H) Ph(2-Cl,3-Et,5-OMe) Ph(2-Cl,3-t-Bu,5-Et) Ph(2-Cl,3-i-Pr,5-OCF₂CF₃) Ph(2-Cl,3-Et,5-OCF₃) Ph(2-Cl,3-t-Bu,5-n-Pr) Ph(2-Cl,3-i-Pr,5-SO₂Me) Ph(2-Cl,3-Et,5-OCHF₂) Ph(2-Cl,3,5-di-t-Bu) Ph(2-Cl,3-i-Pr,5-TMS) Ph(2-Cl,3-Et,5-OCF₂CF₂H) Ph(2-Cl,3-t-Bu,5-i-Pr) Ph(2-Cl,3-i-Pr,5-CN) Ph(2-Cl,3-Et,5-OCF₂CF₃) Ph(2-Cl,3-t-Bu,5-c-Pr) Ph(2-Cl,3-c-Pr,5-Cl) Ph(2-Cl,3-Et,5-SO₂Me) Ph(2-Cl,3-t-Bu,5-CF₃) Ph(2-Cl,3-c-Pr,5-F) Ph(2-Cl,3-Et,5-TMS) Ph(2-Cl,3-t-Bu,5-CF₂CF₃) Ph(2-Cl,3-c-Pr,5-Br) Ph(2-Cl,3-Et,5-CN) Ph(2-Cl,3-t-Bu,5-CF₂CF₂H) Ph(2-Cl,3-c-Pr,5-I) Ph(2-Cl,3-n-Pr,5-Cl) Ph(2-Cl,3-t-Bu,5-CF₂H) Ph(2-Cl,3-c-Pr,5-Me) Ph(2-Cl,3-n-Pr,5-F) Ph(2-Cl,3-t-Bu,5-OMe) Ph(2-Cl,3-c-Pr,5-Ei) Ph(2-Cl,3-n-Pr,5-Br) Ph(2-Cl,3-t-Bu,5-OCF₃) Ph(2-Cl,3-c-Pr,5-n-Pr) Ph(2-Cl,3-n-Pr,5-I) Ph(2-Cl,3-t-Bu,5-OCHF₂) Ph(2-Cl,3-c-Pr,5-t-Bu) Ph(2-Cl,3-n-Pr,5-Me) Ph(2-Cl,3-t-Bu,5-OCF₂CF₂H) Ph(2-Cl,3-c-Pr,5-i-Pr) Ph(2-Cl,3-n-Pr,5-Et) Ph(2-Cl,3-t-Bu,5-OCF₂CF₃) Ph(2-Cl,3,5-di-c-Pr) Ph(2-Cl,3,5-di-n-Pr) Ph(2-Cl,3-t-Bu,5-SO₂Me) Ph(2-Cl,3-c-Pr,5-CF₃) Ph(2-Cl,3-n-Pr,5-t-Bu) Ph(2-Cl,3-t-Bu,5-TMS) Ph(2-Cl,3-c-Pr,5-CF₂CF₃) Ph(2-Cl,3-n-Pr,5-i-Pr) Ph(2-Cl,3-t-Bu,5-CN) Ph(2-Cl,3-c-Pr,5-CF₂CF₂H) Ph(2-Cl,3-n-Pr,5-c-Pr) Ph(2-Cl,3-i-Pr,5-Cl) Ph(2-Cl,3-c-Pr,5-CF₂H) Ph(2-Cl,3-n-Pr,5-CF₃) Ph(2-Cl,3-i-Pr,5-F) Ph(2-Cl,3-c-Pr,5-OMe) Ph(2-Cl,3-c-Pr,5-OCF) Ph(2-Cl,3-CF₂CF₃,5-n-Pr) Ph(2-Cl,3-CF₂CF₂H,5-SO₂Me) Ph(2-Cl,3-c-Pr,5-OCHF₂) Ph(2-Cl,3-CF₂CF₃,5-t-Bu) Ph(2-Cl,3-CF₂CF₂H,5-TMS) Ph(2-Cl,3-c-Pr,5-OCF₂CF₂H) Ph(2-Cl,3-CF₂CF₃,5-i-Pr) Ph(2-Cl,3-CF₂CF₂H,5-CN) Ph(2-Cl,3-c-Pr,5-OCF₂CF₃) Ph(2-Cl,3-CF₂CF₃,5-c-Pr) Ph(2-Cl,3-CF₂H,5-Cl) Ph(2-Cl,3-c-Pr,5-SO₂Me) Ph(2-Cl,3-CF₂CF₃CF₃,5-CF₃) Ph(2-Cl,3-CF₂H,5-F) Ph(2-Cl,3-c-Pr,5-TMS) Ph(2-Cl,3,5-di-CF₂CF₃) Ph(2-Cl,3-CF₂H,5-Br) Ph(2-Cl,3-c-Pr,5-CN) Ph(2-Cl,3-CF₂CF₃,5-CF₂CF₂H) Ph(2-Cl,3-CF₂H,5-I) Ph(2-Cl,3-CF₃,5-Cl) Ph(2-Cl,3-CF₂CF₃,5-CF₂H) Ph(2-Cl,3-CF₂H,5-Me) Ph(2-Cl,3-CF₃,5-F) Ph(2-Cl,3-CF₂CF₃,5-OMe) Ph(2-Cl,3-CF₂H,5-Et) Ph(2-Cl,3-CF₃,5-Br) Ph(2-Cl,3-CF₂CF₃,5-OCF₃) Ph(2-Cl,3-CF₂H,5-n-Pr) Ph(2-Cl,3-CF₃,5-I) Ph(2-Cl,3-CF₂CF₃,5-OCHF₂) Ph(2-Cl,3-CF₂H,5-t-Bu) Ph(2-Cl,3-CF₃,5-Me) Ph(2-Cl,3-CF₂CF₃,5-OCF₂CF₂H) Ph(2-Cl,3-CF₂H,5-i-Pr) Ph(2-Cl,3-CF₃,5-Ei) Ph(2-Cl,3-CF₂CF₃,5-OCF₂CF₃) Ph(2-Cl,3-CF₂H,5-c-Pr) Ph(2-Cl,3-CF₃,5-n-Pr) Ph(2-Cl,3-CF₂CF₃,5-SO₂Me) Ph(2-Cl,3-CF₂H,5-CF₃) Ph(2-Cl,3-CF₃,5-t-Bu) Ph(2-Cl,3-CF₂CF₃,5-TMS) Ph(2-Cl,3-CF₂H,5-CF₂CF₃) Ph(2-Cl,3-CF₃,5-i-Pr) Ph(2-Cl,3-CF₂CF₃,5-CN) Ph(2-Cl,3-CF₂H,5-CF₂CF₂H) Ph(2-Cl,3-CF₃,5-c-Pr) Ph(2-Cl,3-CF₂CF₂H,5-Cl) Ph(2-Cl,3,5-di-CF₂H) Ph(2-Cl,3,5-di-CF₃) Ph(2-Cl,3-CF₂CF₂H,5-F) Ph(2-Cl,3-CF₂H,5-OMe) Ph(2-Cl,3-CF₃,5-CF₂CF₃) Ph(2-Cl,3-CF₂CF₂H,5-Br) Ph(2-Cl,3-CF₂H,5-OCF₃) Ph(2-Cl,3-CF,5-CF₂CF₂H) Ph(2-Cl,3-CF₂CF₂H,5-I) Ph(2-Cl,3-CF₂H,5-OCHF₂) Ph(2-Cl,3-CF₃,5-CF₂H) Ph(2-Cl,3-CF₂CF₂H,5-Me) Ph(2-Cl,3-CF₂H,5-OCF₂CF₂H) Ph(2-Cl,3-CF₃,5-OMe) Ph(2-Cl,3-CF₂CF₂H,5-Ei) Ph(2-Cl,3-CF₂H,5-OCF₂CF₃) Ph(2-Cl,3-CF₃,5-OCF₃) Ph(2-Cl,3-CF₂CF₂H,5-n-Pr) Ph(2-Cl,3-CF₂H,5-SO₂Me) Ph(2-Cl,3-CF₃,5-OCHF₂) Ph(2-Cl,3-CF₂CF₂H,5-t-Bu) Ph(2-Cl,3-CF₂H,5-TMS) Ph(2-Cl,3-CF₃,5-OCF₂CF₂H) Ph(2-Cl,3-CF₂CF₂H,5-i-Pr) Ph(2-Cl,3-CF₂H,5-CN) Ph(2-Cl,3-CF₃,5-OCF₂CF₃) Ph(2-Cl,3-CF₂CF₂H,5-c-Pr) Ph(2-Cl,3-OMe,5-Cl) Ph(2-Cl,3-CF₃,5-SO₂Me) Ph(2-Cl,3-CF₂CF₂HCF₃,5-CF₃) Ph(2-Cl,3-OMe,5-F) Ph(2-Cl,3-CF₃,5-IMS) Ph(2-Cl,3-CF₂CF₂H,5-CF₂CF₃) Ph(2-Cl,3-OMe,5-Br) Ph(2-Cl,3-CF₃,5-CN) Ph(2-Cl,3,5-di-CF₂CF₂H) Ph(2-Cl,3-OMe,5-I) Ph(2-Cl,3-CF₂CF₃,5-Cl) Ph(2-Cl,3-CF₂CF₂H,5-CF₂H) Ph(2-Cl,3-OMe,5-Me) Ph(2-Cl,3-CF₂CF₃,5-F) Ph(2-Cl,3-CF₂CF₂H,5-OMe) Ph(2-Cl,3-OMe,5-Ei) Ph(2-Cl,3-CF₂CF₃,5-Br) Ph(2-Cl,3-CF₂CF₂H,5-OCF₃) Ph(2-Cl,3-OMe,5-n-Pr) Ph(2-Cl,3-CF₂CF₃,5-I) Ph(2-Cl,3-CF₂CF₂H,5-OCHF₂) Ph(2-Cl,3-OMe,5-t-Bu) Ph(2-Cl,3-CF₂CF₃,5-Me) Ph(2-Cl,3-CF₂CF₂H,5-OCF₂CF₂H) Ph(2-Cl,3-OMe,5-i-Pr) Ph(2-Cl,3-CF₂CF₃,5-Ei) Ph(2-Cl,3-CF₂CF₂H,5-OCF₂CF₃) Ph(2-Cl,3-OMe,5-c-Pr) Ph(2-Cl,3-OMeCF₃,5-CF₃) Ph(2-Cl,3-OCHF₂,5-F) Ph(2-Cl,3-OCF₂CF₂H,5-OMe) Ph(2-Cl,3-OMe,5-CF₂CF₃) Ph(2-Cl,3-OCHF₂,5-Br) Ph(2-Cl,3-OCF₂CF₂H,5-OCF₃) Ph(2-Cl,3-OMe,5-CF₂CF₂H) Ph(2-Cl,3-OCHF₂,5-I) Ph(2-Cl,3-OCF₂CF₂H,5-OCHF₂) Ph(2-Cl,3-OMe,5-CF₂H) Ph(2-Cl,3-OCHF₂,5-Me) Ph(2-Cl,3,5-di-OCF₂CF₂H) Ph(2-Cl,3,5-di-OMe) Ph(2-Cl,3-OCHF₂,5-Ei) Ph(2-Cl,3-OCF₂CF₂H,5-OCF₂CF₃) Ph(2-Cl,3-OMe,5-OCF₃) Ph(2-Cl,3-OCHF₂,5-n-Pr) Ph(2-Cl,3-OCF₂CF₂H,5-SO₂Me) Ph(2-Cl,3-OMe,5-OCHF₂) Ph(2-Cl,3-OCHF₂,5-t-Bu) Ph(2-Cl,3-OCF₂CF₂H,5-TMS) Ph(2-Cl,3-OMe,5-OCF₂CF₂H) Ph(2-Cl,3-OCHF₂,5-i-Pr) Ph(2-Cl,3-OCF₂CF₂H,5-CN) Ph(2-Cl,3-OMe,5-OCF₂CF₃) Ph(2-Cl,3-OCHF₂,5-c-Pr) Ph(2-Cl,3-OCF₂CF₃,5-Cl) Ph(2-Cl,3-OMe,5-SO₂Me) Ph(2-Cl,3-OCHF₂CF₃,5-CF₃) Ph(2-Cl,3-OCF₂CF₃,5-F) Ph(2-Cl,3-OMe,5-TMS) Ph(2-Cl,3-OCF₂CF₃,5-CF₂CF₃) Ph(2-Cl,3-OCF₂CF₃,5-Br) Ph(2-Cl,3-OMe,5-CN) Ph(2-Cl,3-OCHF₂,5-CF₂CF₂H) Ph(2-Cl,3-OCF₂CF₃,5-I) Ph(2-Cl,3-OCF₃,5-Cl) Ph(2-Cl,3-OCHF₂,5-CF₂H) Ph(2-Cl,3-OCF₂CF₃,5-Me) Ph(2-Cl,3-OCF₃,5-F) Ph(2-Cl,3-OCHF₂,5-OMe) Ph(2-Cl,3-OCF₂CF₃,5-Ei) Ph(2-Cl,3-OCF₃,5-Br) Ph(2-Cl,3-OCHF₂,5-OCF₃) Ph(2-Cl,3-OCF₂CF₃,5-n-Pr) Ph(2-Cl,3-OCF₃,5-I) Ph(2-Cl,3,5-di-OCHF₂) Ph(2-Cl,3-OCF₂CF₃,5-t-Bu) Ph(2-Cl,3-OCF₃,5-Me) Ph(2-Cl,3-OCHF₂,5-OCF₂CF₂H) Ph(2-Cl,3-OCF₂CF₃,5-i-Pr) Ph(2-Cl,3-OCF₃,5-Ei) Ph(2-Cl,3-OCHF₂,5-OCF₂CF₃) Ph(2-Cl,3-OCF₂CF₃,5-c-Pr) Ph(2-Cl,3-OCF₃,5-n-Pr) Ph(2-Cl,3-OCHF₂,5-SO₂Me) Ph(2-Cl,3-OCF₂CF₃CF₃,5-CF₃) Ph(2-Cl,3-OCF₃,5-t-Bu) Ph(2-Cl,3-OCHF₂,5-TMS) Ph(2-Cl,3-OCF₂CF₃,5-CF₂CF₃) Ph(2-Cl,3-OCF₃,5-i-Pr) Ph(2-Cl,3-OCHF₂,5-CN) Ph(2-Cl,3-OCF₂CF₃,5-CF₂CF₂H) Ph(2-Cl,3-OCF₃,5-c-Pr) Ph(2-Cl,3-OCF₂CF₂H,5-Cl) Ph(2-Cl,3-OCF₂CF₃,5-CF₂H) Ph(2-Cl,3-OCF₃,5-CF₃) Ph(2-Cl,3-OCF₂CF₂H,5-F) Ph(2-Cl,3-OCF₂CF₃,5-OMe) Ph(2-Cl,3-OCF₃,5-CF₂CF₃) Ph(2-Cl,3-OCF₂CF₂H,5-Br) Ph(2-Cl,3-OCF₂CF₃,5-OCF₃) Ph(2-Cl,3-OCF₃,5-CF₂CF₂H) Ph(2-Cl,3-OCF₂CF₂H,5-I) Ph(2-Cl,3-OCF₂CF₃,5-OCHF₂) Ph(2-Cl,3-OCF₃,5-CF₂H) Ph(2-Cl,3-OCF₂CF₂H,5-Me) Ph(2-Cl,3-OCF₂CF₃,5-OCF₂CF₂H) Ph(2-Cl,3-OCF₃,5-OMe) Ph(2-Cl,3-OCF₂CF₂H,5-Ei) Ph(2-Cl,3,5-di-OCF₂CF₃) Ph(2-Cl,3,5-di-OCF₃) Ph(2-Cl,3-OCF_(2l CF2)H,5-n-Pr) Ph(2-Cl,3-OCF₂CF₃,5-SO₂Me) Ph(2-Cl,3-OCHF₂) Ph(2-Cl,3-OCF₂CF₂H,5-t-Bu) Ph(2-Cl,3-OCF₂CF₃,5-TMS) Ph(2-Cl,3-OCF₃,5-OCF₂CF₂H) Ph(2-Cl,3-OCF₂CF₂H,5-i-Pr) Ph(2-Cl,3-OCF₂CF₃,5-CN) Ph(2-Cl,3-OCF₃,5-OCF₂CF₃) Ph(2-Cl,3-OCF₂CF₂H,5-c-Pr) Ph(2-Cl,3-SO₂Me,5-Cl) Ph(2-Cl,3-OCF₃,5-SO₂Me) Ph(2-Cl,3-OCF₂CF₂HCF₃,5-CF₃) Ph(2-Cl,3-SO₂Me,5-F) Ph(2-Cl,3-OCF₃,5-TMS) Ph(2-Cl,3-OCF₂CF₂H,5-CF₂CF₃) Ph(2-Cl,3-SO₂Me,5-Br) Ph(2-Cl,3-OCF₃,5-CN) Ph(2-Cl,3-OCF₂CF₂H,5-CF₂CF₂H) Ph(2-Cl,3-SO₂Me,5-I) Ph(2-Cl,3-OCHF₂,5-Cl) Ph(2-Cl,3-OCF₂CF₂H,5-CF₂H) Ph(2-Cl,3-SO₂Me,5-Me) Ph(2-Cl,3-SO₂Me,5-Ei) Ph(2-Cl,3-TMS,5-OCF₂CF₃) Ph(2-Cl,4-Cl,5-c-Pr) Ph(2-Cl,3-SO₂Me,5-n-Pr) Ph(2-Cl,3-TMS,5-SO₂Me) Ph(2-Cl,4-Cl,5-CF₃) Ph(2-Cl,3-SO₂Me,5-t-Bu) Ph(2-Cl,3,5-di-TMS) Ph(2-Cl,4-Cl,5-CF₂CF₃) Ph(2-Cl,3-SO₂Me,5-i-Pr) Ph(2-Cl,3-TMS,5-CN) Ph(2-Cl,4-Cl,5-CFCF₂H) Ph(2-Cl,3-SO₂Me,5-c-Pr) Ph(2-Cl,3-CN,5-Cl) Ph(2-Cl,4-Cl,5-CF₂H) Ph(2-Cl,3-SO₂MeCF₃,5-CF₃) Ph(2-Cl,3-CN,5-F) Ph(2-Cl,4-Cl,5-OMe) Ph(2-Cl,3-SO₂Me,5-CF₂CF₃) Ph(2-Cl,3-CN,5-Br) Ph(2-Cl,4-Cl,5-OCF₃) PPh(2-Cl,3-SO₂Me,5-CF₂CF₂H) Ph(2-Cl,3-CN,5-I) Ph(2-Cl,4-Cl,5-OCHF₂) Ph(2-Cl,3-SO₂Me,5-CF₂H) Ph(2-Cl,3-CN,5-Me) Ph(2-Cl,4-Cl,5-OCF₂CF₂H) Ph(2-Cl,3-SO₂Me,5-OMe) Ph(2-Cl,3-CN,5-Ei) Ph(2-Cl,4-Cl,5-OCF₂CF₃) Ph(2-Cl,3-SO₂Me,5-OCF₃) Ph(2-Cl,3-CN,5-n-Pr) Ph(2-Cl,4-Cl,5-SO₂Me) Ph(2-Cl,3-SO₂Me,5-OCHF₂) Ph(2-Cl,3-CN,5-t-Bu) Ph(2-Cl,4-Cl,5-TMS) Ph(2-Cl,3-SO₂Me,5-OCF₂CF₂H) Ph(2-Cl,3-CN,5-i-Pr) Ph(2-Cl,4-Cl,5-CN) Ph(2-Cl,3-SO₂Me,5-OCF₂CF₃) Ph(2-Cl,3-CN,5-c-Pr) Ph(2-Cl,4-F,5-Cl) Ph(2-Cl,3,5-di-SO₂Me) Ph(2-Cl,3-CN,5-CF₃) Ph(2-Cl,4,5-di-F) Ph(2-Cl,3-SO₂Me,5-TMS) Ph(2-Cl,3-CN,5-CF₂CF₃) Ph(2-Cl,4-F,5-Br) Ph(2-Cl,3-SO₂Me,5-CN) Ph(2-Cl,3-CN,5-CF₂CF₂H) Ph(2-Cl,4-F,5-I) Ph(2-Cl,3-TMS,5-Cl) Ph(2-Cl,3-CN,5-CF₂H) Ph(2-Cl,4-F,5-Me) Ph(2-Cl,3-TMS,5-F) Ph(2-Cl,3-CN,5-OMe) Ph(2-Cl,4-F,5-Et) Ph(2-Cl,3-TMS,5-Br) Ph(2-Cl,3-CN,5-OCF) Ph(2-Cl,4-F,5-n-Pr) Ph(2-Cl,3-TMS,5-I) Ph(2-Cl,3-CN,5-OCHF₂) Ph(2-Cl,4-F,5-t-Bu) Ph(2-Cl,3-TMS,5-Me) Ph(2-Cl,3-CN,5-OCF₂CF₂H) Ph(2-Cl,4-F,5-i-Pr) Ph(2-Cl,3-TMS,5-Ei) Ph(2-Cl,3-CN,5-OCF₂CF) Ph(2-Cl,4-F,5-c-Pr) Ph(2-Cl,3-TMS,5-n-Pr) Ph(2-Cl,3-CN,5-SO₂Me) Ph(2-Cl,4-F,5-CF₃) Ph(2-Cl,3-TMS,5-t-Bu) Ph(2-Cl,3-CN,5-TMS) Ph(2-Cl,4-F,5-CF₂CF₃) Ph(2-Cl,3-TMS,5-i-Pr) Ph(2-Cl,3,5-di-CN) Ph(2-Cl,4-F,5-CF₂CF₂H) Ph(2-Cl,3-TMS,5-c-Pr) Ph(2,4,5-tri-Cl) Ph(2-Cl,4-F,5-CF₂H) Ph(2-Cl,3-TMS,5-CF₃) Ph(2-Cl,4-Cl,5-F) Ph(2-Cl,4-F,5-OMe) Ph(2-Cl,3-TMS,5-CF₂CF₃) Ph(2-Cl,4-Cl,5-Br) Ph(2-Cl,4-F,5-OCF) Ph(2-Cl,3-TMS,5-CF₂CF₂H) Ph(2-Cl,4-Cl,5-I) Ph(2-Cl,4-F,5-OCHF₂) Ph(2-Cl,3-TMS,5-CF₂H) Ph(2-Cl,4-Cl,5-Me) Ph(2-Cl,4-F,5-OCF₂CF₂H) Ph(2-Cl,3-TMS,5-OMe) Ph(2-Cl,4-Cl,5-Et) Ph(2-Cl,4-F,5-OCF₂CF₃) Ph(2-Cl,3-TMS,5-OCF₃) Ph(2-Cl,4-Cl,5-n-Pr) Ph(2-Cl,4-F,5-SO₂Me) Ph(2-Cl,3-TMS,5-OCHF₂) Ph(2-Cl,4-Cl,5-t-Bu) Ph(2-Cl,4-F,5-TMS) Ph(2-Cl,3-TMS,5-OCF₂CF₂H) Ph(2-Cl,4-Cl,5-i-Pr) Ph(2-Cl,4-F,5-CN) Ph(2-Cl,4-Br,5-Cl) Ph(2-Cl,4-I,5-CF₂H) Ph(2-Cl,4-Et,5-Me) Ph(2-Cl,4-Br,5-F) Ph(2-Cl,4-I,5-OMe) Ph(2-Cl,4,5-di-Et) Ph(2-Cl,4,5-di-Br) Ph(2-Cl,4-I,5-OCF₃) Ph(2-Cl,4-Et,5-n-Pr) Ph(2-Cl,4-Br,5-I) Ph(2-Cl,4-I,5-OCHF₂) Ph(2-Cl,4-Et,5-t-Bu) Ph(2-Cl,4-Br,5-Me) Ph(2-Cl,4-I,5-OCF₂CF₂H) Ph(2-Cl,4-Et,5-i-Pr) Ph(2-Cl,4-Br,5-Et) Ph(2-Cl,4-I,5-OCF₂CF₃) Ph(2-Cl,4-Et,5-c-Pr) Ph(2-Cl,4-Br,5-n-Pr) Ph(2-Cl,4-I,5-SO₂Me) Ph(2-Cl,4-Et,5-CF₃) Ph(2-Cl,4-Br,5-t-Bu) Ph(2-Cl,4-I,5-TMS) Ph(2-Cl,4-Et,5-CF₂CF₃) Ph(2-Cl,4-Br,5-i-Pr) Ph(2-Cl,4-I,5-CN) Ph(2-Cl,4-Et,5-CF₂CF₂H) Ph(2-Cl,4-Br,5-c-Pr) Ph(2-Cl,4-Me,5-Cl) Ph(2-Cl,4-Et,5-CF₂H) Ph(2-Cl,4-Br,5-CF₃) Ph(2-Cl,4-Me,5-F) Ph(2-Cl,4-Et,5-OMe) Ph(2-Cl,4-Br,5-CF₂CF₃) Ph(2-Cl,4-Me,5-Br) Ph(2-Cl,4-Et,5-OCF₃) Ph(2-Cl,4-Br,5-CF₂CF₂H) Ph(2-Cl,4-Me,5-I) Ph(2-Cl,4-Et,5-OCHF₂) Ph(2-Cl,4-Br,5-CF₂H) Ph(2-Cl,4,5-di-Me) Ph(2-Cl,4-Et,5-OCF₂CF₂H) Ph(2-Cl,4-Br,5-OMe) Ph(2-Cl,4-Me,5-Et) Ph(2-Cl,4-Et,5-OCF₂CF₃) Ph(2-Cl,4-Br,5-OCF₃) Ph(2-Cl,4-Me,5-n-Pr) Ph(2-Cl,4-Et,5-SO₂Me) Ph(2-Cl,4-Br,5-OCHF₂) Ph(2-Cl,4-Me,5-t-Bu) Ph(2-Cl,4-Et,5-TMS) Ph(2-Cl,4-Br,5-CF₂CF₂H) Ph(2-Cl,4-Me,5-i-Pr) Ph(2-Cl,4-Et,5-CN) Ph(2-Cl,4-Br,5-OCF₂CF₃) Ph(2-Cl,4-Me,5-c-Pr) Ph(2-Cl,4-n-Pr,5-Cl) Ph(2-Cl,4-Br,5-SO₂Me) Ph(2-Cl,4-Me,5-CF₃) Ph(2-Cl,4-n-Pr,5-F) Ph(2-Cl,4-Br,5-TMS) Ph(2-Cl,4-Me,5-CF₂CF₃) Ph(2-Cl,4-n-Pr,5-Br) Ph(2-Cl,4-Br,5-CN) Ph(2-Cl,4-Me,5-CF₂CF₂H) Ph(2-Cl,4-n-Pr,5-I) Ph(2-Cl,4-I,5-Cl) Ph(2-Cl,4-Me,5-CFH) Ph(2-Cl,4-n-Pr,5-Me) Ph(2-Cl,4-I,5-F) Ph(2-Cl,4-Me,5-OMe) Ph(2-Cl,4-n-Pr,5-Et) Ph(2-Cl,4-I,5-Br) Ph(2-Cl,4-Me,5-OCF₃) Ph(2-Cl,4,5-di-n-Pr) Ph(2-Cl,4,5-di-I) Ph(2-Cl,4-Me,5-OCHF₂) Ph(2-Cl,4-n-Pr,5-t-Bu) Ph(2-Cl,4-I,5-Me) Ph(2-Cl,4-Me,5-OCF₂CF₂H) Ph(2-Cl,4-n-Pr,5-i-Pr) Ph(2-Cl,4-I,5-Et) Ph(2-C1,4-Me,5-OCFCF₃) Ph(2-Cl,4-n-Pr,5-c-Pr) Ph(2-Cl,4-I,5-n-Pr) Ph(2-Cl,4-Me,5-SO₂Me) Ph(2-Cl,4-n-Pr,5-CF₃) Ph(2-Cl,4-I,5-t-Bu) Ph(2-Cl,4-Me,5-TMS) Ph(2-Cl,4-n-Pr,5-CF₂CF₃) Ph(2-Cl,4-I,5-i-Pr) Ph(2-Cl,4-Me,5-CN) Ph(2-Cl,4-n-Pr,5-CF₂CF₂H) Ph(2-C1,4-I,5-c-Pr) Ph(2-Cl,4-Et,5-Cl) Ph(2-Cl,4-n-Pr,5-CF₂H) Ph(2-Cl,4-I,5-CF₃) Ph(2-Cl,4-Et,5-F) Ph(2-Cl,4-n-Pr,5-OMe) Ph(2-Cl,4-I,5-CF₂CF₃) Ph(2-Cl,4-Et,5-Br) Ph(2-Cl,4-n-Pr,5-OCF₃) Ph(2-Cl,4-I,5-CF₂CF₂H) Ph(2-Cl,4-Et,5-I) Ph(2-Cl,4-n-Pr,5-OCHF₂) Ph(2-Cl,4-n-Pr,5-OCF₂CF₂H) Ph(2-Cl,4,5-di-i-Pr) Ph(2-Cl,4-c-Pr,5-CN) Ph(2-Cl,4-n-Pr,5-OCF₂CF₃) Ph(2-Cl,4-i-Pr,5-c-Pr) Ph(2-Cl,4-CF₃,5-Cl) Ph(2-Cl,4-n-Pr,5-SO₂Me) Ph(2-Cl,4-i-Pr,5-CF₃H) Ph(2-Cl,4-CF₃,5-F) Ph(2-Cl,4-n-Pr,5-TMS) Ph(2-Cl,4-i-Pr,5-CF₂CF₃) Ph(2-Cl,4-CF₃,5-Br) Ph(2-Cl,4-n-Pr,5-CN) Ph(2-Cl,4-i-Pr,5-CF₂CF₂H) Ph(2-Cl,4-CF₃,5-I) Ph(2-Cl,4-t-Bu,5-Cl) Ph(2-Cl,4-i-Pr,5-CF₂H) Ph(2-Cl,4-CF₃,5-Me) Ph(2-Cl,4-t-Bu,5-F) Ph(2-Cl,4-i-Pr,5-OMe) Ph(2-Cl,4-CF₃,5-Ei) Ph(2-Cl,4-t-Bu,5-Br) Ph(2-Cl,4-i-Pr,5-OCF₃) Ph(2-Cl,4-CF₃,5-n-Pr) Ph(2-Cl,4-t-Bu,5-I) Ph(2-Cl,4-i-Pr,5-OCHF₂) Ph(2-Cl,4-CF₃,5-t-Bu) Ph(2-Cl,4-t-Bu,5-Me) Ph(2-Cl,4-i-Pr,5-OCF₂CF₂H) Ph(2-Cl,4-CF₃,5-i-Pr) Ph(2-Cl,4-t-Bu,5-Et) Ph(2-Cl,4-i-Pr,5-OCF₂CF₃) Ph(2-Cl,4-CF₃,5-c-Pr) Ph(2-Cl,4-t-Bu,5-n-Pr) Ph(2-Cl,4-i-Pr,5-SO₂Me) Ph(2-Cl,4,5-di-CF₃) Ph(2-Cl,4,5-di-t-Bu) Ph(2-Cl,4-i-Pr,5-TMS) Ph(2-Cl,4-CF₃,5-CF₂CF₃) Ph(2-Cl,4-t-Bu,5-i-Pr) Ph(2-Cl,4-i-Pr,5-CN) Ph(2-Cl,4-CF₃,5-CF₂CF₂H) Ph(2-Cl,4-t-Bu,5-c-Pr) Ph(2-Cl,4-c-Pr,5-Cl) Ph(2-Cl,4-CF₃,5-CF₂H) Ph(2-Cl,4-t-Bu,5-CF₃) Ph(2-Cl,4-c-Pr,5-F) Ph(2-Cl,4-CF₃,5-OMe) Ph(2-Cl,4-t-Bu,5-CF₂CF₃) Ph(2-Cl,4-c-Pr,5-Br) Ph(2-Cl,4-CF₃,5-OCF₃) Ph(2-Cl,4-t-Bu,5-CF₂CF₂H) Ph(2-Cl,4-c-Pr,5-I) Ph(2-Cl,4-CF₃,5-OCHF₂) Ph(2-Cl,4-t-Bu,5-CF₂H) Ph(2-Cl,4-c-Pr,5-Me) Ph(2-Cl,4-CF₃,5-OCF₂CF₂H) Ph(2-Cl,4-t-Bu,5-OMe) Ph(2-Cl,4-c-Pr,5-Ei) Ph(2-Cl,4-CF₃,5-OCF₂CF₃) Ph(2-Cl,4-t-Bu,5-OCF₃) Ph(2-Cl,4-c-Pr,5-n-Pr) Ph(2-Cl,4-CF₃,5-SO₂Me) Ph(2-Cl,4-t-Bu,5-OCHF₂) Ph(2-Cl,4-c-Pr,5-t-Bu) Ph(2-Cl,4-CF₃,5-IMS) Ph(2-Cl,4-t-Bu,5-OCF₂CF₂H) Ph(2-Cl,4-c-Pr,5-i-Pr) Ph(2-Cl,4-CF₃,5-CN) Ph(2-Cl,4-t-Bu,5-OCF₂CF₃) Ph(2-Cl,4,5-di-c-Pr) Ph(2-Cl,4-CF₂CF₃,5-Cl) Ph(2-Cl,4-t-Bu,5-SO₂Me) Ph(2-Cl,4-c-Pr,5-CF₃H) Ph(2-Cl,4-CF₂CF₃,5-F) Ph(2-Cl,4-t-Bu,5-TMS) Ph(2-Cl,4-c-Pr,5-CF₂CF₃) Ph(2-Cl,4-CF₂CF₃,5-Br) Ph(2-Cl,4-t-Bu,5-CN) Ph(2-Cl,4-c-Pr,5-CF₂CF₂H) Ph(2-Cl,4-CF₂CF₃,5-I) Ph(2-Cl,4-i-Pr,5-Cl) Ph(2-Cl,4-c-Pr,5-CF₂H) Ph(2-Cl,4-CF₂CF₃,5-Me) Ph(2-Cl,4-i-Pr,5-F) Ph(2-Cl,4-c-Pr,5-OMe) Ph(2-Cl,4-CF₂CF₃,5-Ei) Ph(2-Cl,4-i-Pr,5-Br) Ph(2-Cl,4-c-Pr,5-OCF₃) Ph(2-Cl,4-CF₂CF₃,5-n-Pr) Ph(2-Cl,4-i-Pr,5-I) Ph(2-Cl,4-c-Pr,5-OCHF₂) Ph(2-Cl,4-CF₂CF₃,5-t-Bu) Ph(2-Cl,4-i-Pr,5-Me) Ph(2-Cl,4-c-Pr,5-OCF₂CF₂H) Ph(2-Cl,4-CF₂CF₃,5-i-Pr) Ph(2-Cl,4-i-Pr,5-Ei) Ph(2-Cl,4-c-Pr,5-OCF₂CF₃) Ph(2-Cl,4-CF₂CF₃,5-c-Pr) Ph(2-Cl,4-i-Pr,5-n-Pr) Ph(2-Cl,4-c-Pr,5-SO₂Me) Ph(2-Cl,4-CF₂CF₃CF₃,5-CF₃) Ph(2-Cl,4-i-Pr,5-t-Bu) Ph(2-Cl,4-c-Pr,5-TMS) Ph(2-Cl,4,5-di-CF₂CF₃) Ph(2-Cl,4-CF₂CF₃,5-CF₂CF₂H) Ph(2-Cl,4-CF₂H,5-I) Ph(2-Cl,4-OMe,5-OCHF₂) Ph(2-Cl,4-CF₂CF₃,5-CF₂H) Ph(2-Cl,4-CF₂H,5-Me) Ph(2-Cl,4-OMe,5-OCF₂CF₂H) Ph(2-Cl,4-CF₂CF₃,5-OMe) Ph(2-Cl,4-CF₂H,5-Ei) Ph(2-Cl,4-OMe,5-OCF₂CF₃) Ph(2-Cl,4-CF₂CF₃,5-OCF₃) Ph(2-Cl,4-CF₂H,5-n-Pr) Ph(2-Cl,4-OMe,5-SO₂Me) Ph(2-Cl,4-CF₂CF₃,5-OCHF₂) Ph(2-Cl,4-CF₂H,5-t-Bu) Ph(2-Cl,4-OMe,5-TMS) Ph(2-Cl,4-CF₂CF₃,5-OCF₂CF₂H) Ph(2-Cl,4-CF₂H,5-i-Pr) Ph(2-Cl,4-OMe,5-CN) PPh(2-Cl,4-CF₂CF₃,5-OCF₂CF₃) Ph(2-Cl,4-CF₂H,5-c-Pr) Ph(2-Cl,4-OCF₃,5-Cl) Ph(2-Cl,4-CF₂CF₃,5-SO₂Me) Ph(2-Cl,4-CF₂H,5-CF₃) Ph(2-Cl,4-OCF₃,5-F) Ph(2-Cl,4-CF₂CF₃,5-TMS) Ph(2-Cl,4-CF₂H,5-CF₂CF₃) Ph(2-Cl,4-OCF₃,5-Br) Ph(2-Cl,4-CF₂CF₃,5-CN) Ph(2-Cl,4-CF₂H,5-CF₂CF₂H) Ph(2-Cl,4-OCF₃,5-I) Ph(2-Cl,4-CF₂CF₂H,5-Cl) Ph(2-Cl,4,5-di-CF₂H) Ph(2-Cl,4-OCF₃,5-Me) Ph(2-Cl,4-CF₂CF₂H,5-F) Ph(2-Cl,4-CF₂H,5-OMe) Ph(2-Cl,4-OCF₃,5-Ei) Ph(2-Cl,4-CF₂CF₂H,5-Br) Ph(2-Cl,4-CF₂H,5-OCF₃) Ph(2-Cl,4-OCF₃,5-n-Pr) Ph(2-Cl,4-CF₂CF₂H,5-I) Ph(2-Cl,4-CF₂H,5-OCHF₂) Ph(2-Cl,4-OCF₃,5-t-Bu) Ph(2-Cl,4-CF₂CF₂H,5-Me) Ph(2-Cl,4-CF₂H,5-OCF₂CF₂H) Ph(2-Cl,4-OCF₃,5-i-Pr) Ph(2-Cl,4-CF₂CF₂H,5-Ei) Ph(2-Cl,4-CF₂H,5-OCF₂CF₃) Ph(2-Cl,4-OCF₃,5-c-Pr) Ph(2-Cl,4-CF₂CF₂H,5-n-Pr) Ph(2-Cl,4-CF₂H,5-SO₂Me) Ph(2-Cl,4-OCF₃,5-CF₃) Ph(2-Cl,4-CF₂CF₂H,5-t-Bu) Ph(2-Cl,4-CF₂H,5-TMS) Ph(2-Cl,4-OCF₃,5-CF₂CF₃) Ph(2-Cl,4-CF₂CF₂H,5-i-Pr) Ph(2-Cl,4-CF₂H,5-CN) Ph(2-Cl,4-OCF₃,5-CF₂CF₂H) Ph(2-Cl,4-CF₂CF₂H,5-c-Pr) Ph(2-Cl,4-OMe,5-Cl) Ph(2-Cl,4-OCF₃,5-CF₂H) Ph(2-Cl,4-CF₂CF₂HCF₃,5-CF₃) Ph(2-Cl,4-OMe,5-F) Ph(2-Cl,4-OCF₃,5-OMe) Ph(2-Cl,4-CF₂CF₂H,5-CF₂CF₃) Ph(2-Cl,4-OMe,5-Br) Ph(2-Cl,4,5-di-OCF₃) Ph(2-Cl,4,5-di-CF₂CF₂H) Ph(2-Cl,4-OMe,5-I) Ph(2-Cl,4-OCF₃,5-OCHF₂) Ph(2-Cl,4-CF₂CF₂H,5-CF₂H) Ph(2-Cl,4-OMe,5-Me) Ph(2-Cl,4-OCF₃,5-OCF₂CF₂H) Ph(2-Cl,4-CF₂CF₂H,5-OMe) Ph(2-Cl,4-OMe,5-Ei) Ph(2-Cl,4-OCF₃,5-OCF₂CF₃) Ph(2-Cl,4-CF₂CF₂H,5-OCF₃) Ph(2-Cl,4-OMe,5-n-Pr) Ph(2-Cl,4-OCF₃,5-SO₂Me) Ph(2-Cl,4-CF₂CF₂H,5-OCHF₂) Ph(2-Cl,4-OMe,5-t-Bu) Ph(2-Cl,4-OCF₃,5-TMS) Ph(2-Cl,4-CF₂CF₂H,5-OCF₂CF₂H) Ph(2-Cl,4-OMe,5-i-Pr) Ph(2-Cl,4-OCF₃,5-CN) Ph(2-Cl,4-CF₂CF₂H,5-OCF₂CF₃) Ph(2-Cl,4-OMe,5-c-Pr) Ph(2-Cl,4-OCHF₂,5-Cl) Ph(2-Cl,4-CF₂CF₂H,5-SO₂Me) Ph(2-Cl,4-OMeCF₃,5-CF₃) Ph(2-Cl,4-OCHF₂,5-F) Ph(2-Cl,4-CF₂CF₂H,5-TMS) Ph(2-C1,4-OMe,5-CF₂CF₃) Ph(2-Cl,4-OCHF₂,5-Br) Ph(2-Cl,4-CF₂CF₂H,5-CN) Ph(2-Cl,4-OMe,5-CF₂CF₂H) Ph(2-Cl,4-OCHF₂,5-I) Ph(2-Cl,4-CF₂H,5-Cl) Ph(2-Cl,4-OMe,5-CF₂H) Ph(2-Cl,4-OCHF₂,5-Me) Ph(2-Cl,4-CF₂H,5-F) Ph(2-Cl,4,5-di-OMe) Ph(2-Cl,4-OCHF₂,5-Ei) Ph(2-Cl,4-CF₂H,5-Br) Ph(2-Cl,4-OMe,5-OCF₃) Ph(2-Cl,4-OCHF₂,5-n-Pr) Ph(2-Cl,4-OCHF₂,5-t-Bu) Ph(2-Cl,4-oCF₂CF₂H,5-TMS) Ph(2-Cl,4-SO₂Me,5-CF₂CF₃) Ph(2-Cl,4-OCHF₂,5-i-Pr) Ph(2-Cl,4-OCF₂CF₂H,5-CN) Ph(2-Cl,4-SO₂Me,5-CF₂CF₂H) Ph(2-Cl,4-OCHF₂,5-c-Pr) Ph(2-Cl,4-OCF₂CF₃,5-Cl) Ph(2-Cl,4-SO₂Me,5-CF₂H) Ph(2-Cl,4-OCHF₂CF₃,5-CF₃) Ph(2-Cl,4-OCF₂CF₃,5-F) Ph(2-Cl,4-SO₂Me,5-OMe) Ph(2-Cl,4-OCF₂CF₃,5-CF₂CF₃) Ph(2-Cl,4-OCF₂CF₃,5-Br) Ph(2-Cl,4-SO₂Me,5-OCF₃) Ph(2-Cl,4-OCHF₂,5-CF₂CF₂H) Ph(2-Cl,4-OCF₂CF₃,5-I) Ph(2-Cl,4-SO₂Me,5-OCHF₂) Ph(2-Cl,4-OCHF₂,5-CF₂H) Ph(2-Cl,4-OCF₂CF₃,5-Me) Ph(2-Cl,4-SO₂Me,5-OCF₂CF₂H) Ph(2-Cl,4-OCHF₂,5-OMe) Ph(2-Cl,4-OCF₂CF₃,5-Ei) Ph(2-Cl,4-SO₂Me,5-OCF₂CF₃) Ph(2-Cl,4-OCHF₂,5-OCF₃) Ph(2-Cl,4-OCF₂CF₃,5-n-Pr) Ph(2-Cl,4,5-di-SO₂Me) Ph(2-Cl,4,5-di-OCHF₂) Ph(2-Cl,4-OCF₂CF₃,5-t-Bu) Ph(2-Cl,4-SO₂Me,5-TMS) Ph(2-Cl,4-OCHF₂,5-OCF₂CF₂H) Ph(2-Cl,4-OCF₂CF₃,5-i-Pr) Ph(2-Cl,4-SO₂Me,5-CN) Ph(2-Cl,4-OCHF₂,5-OCF₂CF₃) Ph(2-Cl,4-OCF₂CF₃,5-c-Pr) Ph(2-Cl,4-TMS,5-Cl) Ph(2-Cl,4-OCHF₂,5-SO₂Me) Ph(2-Cl,4-OCF₂CF₃CF₃,5-CF₃) Ph(2-Cl,4-TMS,5-F) Ph(2-Cl,4-OCHF₂,5-TMS) Ph(2-Cl,4-OCF₂CF₃,5-CF₂CF₃) Ph(2-Cl,4-TMS,5-Br) Ph(2-Cl,4-OCHF₂,5-CN) Ph(2-Cl,4-OCF₂CF₃,5-CF₂CF₂H) Ph(2-Cl,4-TMS,5-I) Ph(2-Cl,4-OCF₂CF₂H,5-Cl) Ph(2-Cl,4-OCF₂CF₃,5-CF₂H) Ph(2-Cl,4-TMS,5-Me) Ph(2-Cl,4-OCF₂CF₂H,5-F) Ph(2-Cl,4-OCF₂CF₃,5-OMe Ph(2-Cl,4-TMS,5-Ei) Ph(2-Cl,4-OCF₂CF₂H,5-Br) Ph(2-Cl,4-OCF₂CF₃,5-OCF₃) Ph(2-Cl,4-TMS,5-n-Pr) Ph(2-Cl,4-OCF₂CF₂H,5-I) Ph(2-Cl,4-OCF₂CF₃,5-OCHF₂) Ph(2-Cl,4-TMS,5-t-Bu) Ph(2-Cl,4-OCF₂CF₂H,5-Me) Ph(2-Cl,4-OCF₂CF₃,5-OCF₂CF₂H) Ph(2-Cl,4-TMS,5-i--Pr) Ph(2-Cl,4-OCF₂CF₂H,5-Ei) Ph(2-Cl,4,5-di-OCF₂CF₃) Ph(2-Cl,4-TMS,5-c-Pr) Ph(2-Cl,4-OCF₂CF₂H,5-n-Pr) Ph(2-Cl,4-OCF₂CF₃,5-SO₂Me) Ph(2-Cl,4-TMS,5-CF₃) Ph(2-Cl,4-OCF₂CF₂H,5-t-Bu) Ph(2-Cl,4-OCF₂CF₃,5-TMS) Ph(2-Cl,4-TMS,5-CF₂CF₃) Ph(2-Cl,4-OCF₂CF₂H,5-i-Pr) Ph(2-Cl,4-OCF₂CF₃,5-CN) Ph(2-Cl,4-TMS,5-CF₂CF₂H) Ph(2-Cl,4-OCF₂CF₂H,5-c-Pr) Ph(2-Cl,4-SO₂Me,5-Cl) Ph(2-Cl,4-TMS,5-CF₂H) Ph(2-Cl,4-OCF₂CF₂HCF₃,5-CF₃) Ph(2-Cl,4-SO₂Me,5-F) Ph(2-Cl,4-TMS,5-OMe) Ph(2-Cl,4-OCF₂CF₂H,5-CF₂CF₃) Ph(2-Cl,4-SO₂Me,5-Br) Ph(2-Cl,4-TMS,5-OCF₃) Ph(2-Cl,4-OCF₂CF₂H,5-CF₂CF₂H) Ph(2-Cl,4-SO₂Me,5-I) Ph(2-Cl,4-TMS,5-OCHF₂) Ph(2-Cl,4-OCF₂CF₂H,5-CF₂H) Ph(2-Cl,4-SO₂Me,5-Me) Ph(2-Cl,4-TMS,5-OCF₂CF₂H) Ph(2-Cl,4-OCF₂CF₂H,5-OMe) Ph(2-Cl,4-SO₂Me,5-Ei) Ph(2-Cl,4-TMS,5-OCF₂CF₃) Ph(2-Cl,4-OCF₂CF₂H,5-OCF₃) Ph(2-Cl,4-SO₂Me,5-n-Pr) Ph(2-Cl,4-TMS,5-SO₂Me) Ph(2-Cl,4-OCF₂CF₂H,5-OCHF₂) Ph(2-Cl,4-SO₂Me,5-t-Bu) Ph(2-Cl,4,5-di-TMS) Ph(2-Cl,4,5-di-OCF₂CF₂H) Ph(2-Cl,4-SO₂Me,5-i-Pr) Ph(2-Cl,4-TMS,5-CN) Ph(2-Cl,4-OCF₂CF₂H,5-OCF₂CF₃) Ph(2-Cl,4-SO₂Me,5-c-Pr) Ph(2-Cl,4-CN,5-Cl) Ph(2-Cl,4-OCF₂CF₂H,5-SO₂Me) Ph(2-Cl,4-SO₂MeCF₃,5-CF₃) Ph(2-Cl,4-CN,5-F) Ph(2-Cl,4-CN,5-Br) Ph(2-F,3-Cl,4-OCF₃) Ph(2-F,3-Br,4-n-Pr) Ph(2-Cl,4-CN,5-I) Ph(2-F,3-Cl,4-OCHF₂) Ph(2-F,3-Br,4-t-Bu) Ph(2-Cl,4-CN,5-Me) Ph(2-F,3-Cl,4-OCF₂CF₂H) Ph(2-F,3-Br,4-i-Pr) Ph(2-Cl,4-CN,5-Ei) Ph(2-F,3-Cl,4-OCF₂CF₃) Ph(2-F,3-Br,4-c-Pr) Ph(2-C1,4-CN,5-n-Pr) Ph(2-F,3-Cl,4-SO₂Me) Ph(2-F,3-Br,4-CF₃) Ph(2-Cl,4-CN,5-t-Bu) Ph(2-F,3-Cl,4-TMS) Ph(2-F,3-Br,4-CF₂CF₃) Ph(2-Cl,4-CN,5-i-Pr) Ph(2-F,3-Cl,4-CN) Ph(2-F,3-Br,4-CF₂CF₂H) Ph(2-Cl,4-CN,5-c-Pr) Ph(2-F,3-F,4-Cl) Ph(2-F,3-Br,4-CF₂H) Ph(2-Cl,4-CN,5-CF₃) Ph(2,3,4-tri-F) Ph(2-F,3-Br,4-OMe) Ph(2-Cl,4-CN,5-CF₂CF₃) Ph(2-F,3-F,4-Br) Ph(2-F,3-Br,4-OCF₃) Ph(2-Cl,4-CN,5-CF₂CF₂H) Ph(2-F,3-F,4-I) Ph(2-F,3-Br,4-OCHF₂) Ph(2-Cl,4-CN,5-CF₂H) Ph(2-F,3-F,4-Me) Ph(2-F,3-Br,4-OCF₂CF₂H) Ph(2-Cl,4-CN,5-OMe) Ph(2-F,3-F,4-Et) Ph(2-F,3-Br,4-OCF₂CF₃) Ph(2-Cl,4-CN,5-OCF₃) Ph(2-F,3-F,4-n-Pr) Ph(2-F,3-Br,4-SO₂Me) Ph(2-Cl,4-CN,5-OCHF₂) Ph(2-F,3-F,4-t-Bu) Ph(2-F,3-Br,4-TMS) Ph(2-Cl,4-CN,5-OCF₂CF₂H) Ph(2-F,3-F,4-i-Pr) Ph(2-F,3-Br,4-CN) Ph(2-Cl,4-CN,5-OCF₂CF₃) Ph(2-F,3-F,4-c-Pr) Ph(2-F,3-I,4-Cl) Ph(2-Cl,4-CN,5-SO₂Me) Ph(2-F,3-F,4-CF₃) Ph(2-F,3-I,4-F) Ph(2-Cl,4-CN,5-TMS) Ph(2-F,3-F,4-CF₂CF₃) Ph(2-F,3-I,4-Br) Ph(2-Cl,4,5-di-CN) Ph(2-F,3-F,4-CF₂CF₂H) Ph(2-F,3,4-di-I) Ph(2-F,3,4-di-Cl) Ph(2-F,3-F,4-CF₂H) Ph(2-F,3-I,4-Me) Ph(2-F,3-Cl,4-F) Ph(2-F,3-F,4-OMe) Ph(2-F,3-I,4-Et) Ph(2-F,3-Cl,4-Br) Ph(2-F,3-F,4-OCF₃) Ph(2-F,3-I,4-n-Pr) Ph(2-F,3-Cl,4-I) Ph(2-F,3-F,4-OCHF₂) Ph(2-F,3-I,4-t-Bu) Ph(2-F,3-Cl,4-Me) Ph(2-F,3-F,4-OCF₂CF₂H) Ph(2-F,3-I,4-i-Pr) Ph(2-F,3-Cl,4-Et) Ph(2-F,3-F,4-OCF₂CF₃) Ph(2-F,3-I,4-c-Pr) Ph(2-F,3-Cl,4-n-Pr) Ph(2-F,3-F,4-SO₂Me) Ph(2-F,3-I,4-CF₃) Ph(2-F,3-Cl,4-t-Bu) Ph(2-F,3-F,4-TMS) Ph(2-F,3-I,4-CF₂CF₃) Ph(2-F,3-Cl,4-i-Pr) Ph(2-F,3-F,4-CN) Ph(2-F,3-I,4-CF₂CF₂H) Ph(2-F,3-Cl,4-c-Pr) Ph(2-F,3-Br,4-Cl) Ph(2-F,3-I,4-CF₂H) Ph(2-F,3-Cl,4-CF₃) Ph(2-F,3-Br,4-F) Ph(2-F,3-I,4-OMe) Ph(2-F,3-Cl,4-CF₂CF₃) Ph(2-F,3,4-di-Br) Ph(2-F,3-I,4-OCF₃) Ph(2-F,3-Cl,4-CF₂CF₂H) Ph(2-F,3-Br,4-I) Ph(2-F,3-I,4-OCHF₂) Ph(2-F,3-Cl,4-CF₂H) Ph(2-F,3-Br,4-Me) Ph(2-F,3-I,4-OCF₂CF₂H) Ph(2-F,3-Cl,4-OMe) Ph(2-F,3-Br,4-Et) Ph(2-F,3-I,4-OCF₂CF₃) Ph(2-F,3-I,4-SO₂Me) Ph(2-F,3-Et,4-CF₃) Ph(2-F,3-t-Bu,4-F) Ph(2-F,3-I,4-TMS) Ph(2-F,3-Et,4-CF₂CF₃) Ph(2-F,3-t-Bu,4-Br) Ph(2-F,3-I,4-CN) Ph(2-F,3-Et,4-CF₂CF₂H) Ph(2-F,3-t-Bu,4-I) Ph(2-F,3-Me,4-Cl) Ph(2-F,3-Et,4-CF₂H) Ph(2-F,3-t-Bu,4-Me) Ph(2-F,3-Me,4-F) Ph(2-F,3-Et,4-OMe) Ph(2-F,3-t-Bu,4-Et) Ph(2-F,3-Me,4-Br) Ph(2-F,3-Et,4-OCF₃) Ph(2-F,3-t-Bu,4-n-Pr) Ph(2-F,3-Me,4-I) Ph(2-F,3-Et,4-OCHF₂) Ph(2-F,3,4-di-t-Bu) Ph(2-F,3,4-di-Me) Ph(2-F,3-Et,4-OCF₂CF₂H) Ph(2-F,3-t-Bu,4-i-Pr) Ph(2-F,3-Me,4-Et) Ph(2-F,3-Et,4-OCF₂CF₃) Ph(2-F,3-t-Bu,4-c-Pr) Ph(2-F,3-Me,4-n-Pr) Ph(2-F,3-Et,4-SO₂Me) Ph(2-F,3-t-Bu,4-CF₃) Ph(2-F,3-Me,4-t-Bu) Ph(2-F,3-Et,4-TMS) Ph(2-F,3-t-Bu,4-CF₂CF₃) Ph(2-F,3-Me,4-i-Pr) Ph(2-F,3-Et,4-CN) Ph(2-F,3-t-Bu,4-CF₂CF₂H) Ph(2-F,3-Me,4-c-Pr) Ph(2-F,3-n-Pr,4-Cl) Ph(2-F,3-t-Bu,4-CF₂H) Ph(2-F,3-Me,4-CF₃) Ph(2-F,3-n-Pr,4-F) Ph(2-F,3-t-Bu,4-OMe) Ph(2-F,3-Me,4-CF₂CF₃) Ph(2-F,3-n-Pr,4-Br) Ph(2-F,3-t-Bu,4-OCF₃) Ph(2-F,3-Me,4-CF₂CF₂H) Ph(2-F,3-n-Pr,4-I) Ph(2-F,3-t-Bu,4-OCHF₂) Ph(2-F,3-Me,4-CF₂H) Ph(2-F,3-n-Pr,4-Me) Ph(2-F,3-t-Bu,4-OCF₂CF₂H) Ph(2-F,3-Me,4-OMe) Ph(2-F,3-n-Pr,4-Et) Ph(2-F,3-t-Bu,4-OCF₂CF₃) Ph(2-F,3-Me,4-OCF₃) Ph(2-F,3,4-di-n-Pr) Ph(2-F,3-t-Bu,4-SO₂Me) Ph(2-F,3-Me,4-OCHF₂) Ph(2-F,3-n-Pr,4-t-Bu) Ph(2-F,3-t-Bu,4-TMS) Ph(2-F,3-Me,4-OCF₂CF₂H) Ph(2-F,3-n-Pr,4-i-Pr) Ph(2-F,3-t-Bu,4-CN) Ph(2-F,3-Me,4-OCF₂CF₃) Ph(2-F,3-n-Pr,4-c-Pr) Ph(2-F,3-i-Pr,4-Cl) Ph(2-F,3-Me,4-SO₂Me) Ph(2-F,3-n-Pr,4-CF₃) Ph(2-F,3-i-Pr,4-F) Ph(2-F,3-Me,4-TMS) Ph(2-F,3-n-Pr,4-CF₂CF₃) Ph(2-F,3-i-Pr,4-Br) Ph(2-F,3-Me,4-CN) Ph(2-F,3-n-Pr,4-CF₂CF₂H) Ph(2-F,3-i-Pr,4-I) Ph(2-F,3-Et,4-Cl) Ph(2-F,3-n-Pr,4-CF₂H) Ph(2-F,3-i-Pr,4-Me) Ph(2-F,3-Et,4-F) Ph(2-F,3-n-Pr,4-OMe) Ph(2-F,3-i-Pr,4-Ei) Ph(2-F,3-Et,4-Br) Ph(2-F,3-n-Pr,4-OCF₃) Ph(2-F,3-i-Pr,4-n-Pr) Ph(2-F,3-Et,4-I) Ph(2-F,3-n-Pr,4-OCHF₂) Ph(2-F,3-i-Pr,4-t-Bu) Ph(2-F,3-Et,4-Me) Ph(2-F,3-n-Pr,4-OCF₂CF₂H) Ph(2-F,3,4-di-i-Pr) Ph(2-F,3,4-di-Et) Ph(2-F,3-n-Pr,4-OCF₂CF₃) Ph(2-F,3-i-Pr,4-c-Pr) Ph(2-F,3-Et,4-n-Pr) Ph(2-F,3-n-Pr,4-SO₂Me) Ph(2-F,3-i-Pr,4-CF₃) Ph(2-F,3-Et,4-t-Bu) Ph(2-F,3-n-Pr,4-TMS) Ph(2-F,3-i-Pr,4-CF₂CF₃) Ph(2-F,3-Et,4-i-Pr) Ph(2-F,3-n-Pr,4-CN) Ph(2-F,3-i-Pr,4-CF₂CF₂H) Ph(2-F,3-Et,4-c-Pr) Ph(2-F,3-t-Bu,4-Cl) Ph(2-F,3-i-Pr,4-CF₂H) Ph(2-F,3-i-Pr,4-OMe) Ph(2-F,3-CF3,4-Ei) Ph(2-F,3-CF2CF3,4-OCF2CF3) Ph(2-F,3-i-Pr,4-OCF₃) Ph(2-F,3-CF3,4-n-Pr) Ph(2-F,3-CF2CF3,4-SO2Me) Ph(2-F,3-i-Pr,4-OCHF₂) Ph(2-F,3-CF3,4-t-Bu) Ph(2-F,3-CF2CF3,4-TMS) Ph(2-F,3-i-Pr,4-OCF₂CF₂H) Ph(2-F,3-CF3,4-i-Pr) Ph(2-F,3-CF2CF3,4-CN) Ph(2-F,3-i-Pr,4-OCF₂CF₃) Ph(2-F,3-CF3,4-c-Pr) Ph(2-F,3-CF2CF2H,4-C1) Ph(2-F,3-i-Pr,4-SO₂Me) Ph(2-F,3,4-di-CF₃) Ph(2-F,3-CF₂CF₂H,4-F) Ph(2-F,3-i-Pr,4-TMS) Ph(2-F,3-CF₃,4-CF₂CF₃) Ph(2-F,3-CF₂CF₂H,4-Br) Ph(2-F,3-i-Pr,4-CN) Ph(2-F,3-CF₃,4-CF₂CF₂H) Ph(2-F,3-CF₂CF₂H,4-I) Ph(2-F,3-c-Pr,4-Cl) Ph(2-F,3-CF₃,4-CF₂H) Ph(2-F,3-CF₂CF₂H,4-Me) Ph(2-F,3-c-Pr,4-F) Ph(2-F,3-CF₃,4-OMe) Ph(2-F,3-CF₂CF₂H,4-Ei) Ph(2-F,3-c-Pr,4-Br) Ph(2-F,3-CF₃,4-OCF₃) Ph(2-F,3-CF₂CF₂H,4-n-Pr) Ph(2-F,3-c-Pr,4-I) Ph(2-F,3-CF₃,4-OCHF₂) Ph(2-F,3-CF₂CF₂,4-t-Bu) Ph(2-F,3-c-Pr,4-Me) Ph(2-F,3-CF₃,4-OCF₂CF₂H) Ph(2-F,3-CF₂CF₂H,4-i-Pr) Ph(2-F,3-c-Pr,4-Ei) Ph(2-F,3-CF₃,4-OCF₂CF₃) Ph(2-F,3-CF₂CF₂H,4-c-Pr) Ph(2-F,3-c-Pr,4-n-Pr) Ph(2-F,3-CF₃,4-SO₂Me) Ph(2-F,3-CF₂CF₂HCF₃,4-CF₃) Ph(2-F,3-c-Pr,4-t-Bu) Ph(2-F,3-CF₃,4-IMS) Ph(2-F,3-CF₂CF₂H,4-CF₂CF₃) Ph(2-F,3-c-Pr,4-i-Pr) Ph(2-F,3-CF₃,4-CN) Ph(2-F,3,4-di-CF₂CF₂H) Ph(2-F,3,4-di-c-Pr) Ph(2-F,3-CF₂CF₃,4-C1) Ph(2-F,3-CF₂CF₂H,4-CF₂H) Ph(2-F,3-c-Pr,4-CF₃) Ph(2-F,3-CF₂CF₃,4-F) Ph(2-F,3-CF₂CF₂H,4-OMe) Ph(2-F,3-c-Pr,4-CF₂CF₃) Ph(2-F,3-CF₂CF₃,4-Br) Ph(2-F,3-CF₂CF₂H,4-OCF₃) Ph(2-F,3-c-Pr,4-CF₂CF₂H) Ph(2-F,3-CF₂CF₃,4-I) Ph(2-F,3-CF₂CF₂H,4-OCHF₂) Ph(2-F,3-c-Pr,4-CF₂H) Ph(2-F,3-CF₂CF₃,4-Me) Ph(2-F,3-CF₂CF₂H,4-OCF₂CF₂H Ph(2-F,3-c-Pr,4-OMe) Ph(2-F,3-CF₂CF₃,4-Et) Ph(2-F,3-CF₂CF₂H,4-OCF₂CF₃) Ph(2-F,3-c-Pr,4-OCF₃) Ph(2-F,3-CF₂CF₃,4-n-Pr) Ph(2-F,3-CF₂CF₂H,4-SO₂Me) Ph(2-F,3-c-Pr,4-OCHF₂) Ph(2-F,3-CF₂CF₃,4-t-Bu) Ph(2-F,3-CF₂CF₂H,4-TMS) Ph(2-F,3-c-Pr,4-OCF₂CF₂H) Ph(2-F,3-CF₂CF₃,4-i-Pr) Ph(2-F,3-CF₂CF₂H,4-CN) Ph(2-F,3-c-Pr,4-OCF₂CF₃) Ph(2-F,3-CF₂CF₃,4-c-Pr) Ph(2-F,3-CF₂H,4-Cl) Ph(2-F,3-c-Pr,4-SO₂Me) Ph(2-F,3-CF₂CF₃CF₃,4-CF₃) Ph(2-F,3-CF₂H,4-F) Ph(2-F,3-c-Pr,4-TMS) Ph(2-F,3,4-di-CF₂CF₃) Ph(2-F,3-CF₂H,4-Br) Ph(2-F,3-c-Pr,4-CN) Ph(2-F,3-CF₂CF₃,4-CF₂CF₂H) Ph(2-F,3-CF₂H,4-I) Ph(2-F,3-CF3,4-Cl) Ph(2-F,3-CF₂CF₃,4-CF₂H) Ph(2-F,3-CF₂H,4-Me) Ph(2-F,3-CF3,4-F) Ph(2-F,3-CF₂CF₃,4-OMe) Ph(2-F,3-CF₂H,4-Ei) Ph(2-F,3-CF3,4-Br) Ph(2-F,3-CF₂CF₃,4-OCF₃) Ph(2-F,3-CF₂H,4-n-Pr) Ph(2-F,3-CF3,4-I) Ph(2-F,3-CF₂CF₃,4-OOCHF₂) Ph(2-F,3-CF₂H,4-t-Bu) Ph(2-F,3-CF3,4-Me) Ph(2-F,3-CF₂CF₃,4-OCF₂CF₂H) Ph(2-F,3-CF₂H,4-i-Pr) Ph(2-F,3-CF₂H,4-c-Pr) Ph(2-F,3-OCF₃,4-Cl) Ph(2-F,3-OCHF₂,4-CF₂H) Ph(2-F,3-CF₂H,4-CF₃) Ph(2-F,3-OCF₃,4-F) Ph(2-F,3-OCHF₂,4-OMe) Ph(2-F,3-CF₂H,4-CF₂CF₃) Ph(2-F,3-OCF₃,4-Br) Ph(2-F,3-OCHF₂,4-OCF₃) Ph(2-F,3-CF₂H,4-CF₂CF₂H) Ph(2-F,3-OCF₃,4-I) Ph(2-F,3,4-di-OCHF₂) Ph(2-F,3,4-di-CF₂H) Ph(2-F,3-OCF₃,4-Me) Ph(2-F,3-OCHF₂,4-OCF₂CF₂H) Ph(2-F,3-CF₂H,4-OMe) Ph(2-F,3-OCF₃,4-Ei) Ph(2-F,3-OCHF₂,4-OCF₂CF₃) Ph(2-F,3-CF₂H,4-OCF₃) Ph(2-F,3-OCF₃,4-n-Pr) Ph(2-F,3-OCHF₂,4-SO₂Me) Ph(2-F,3-CF₂H,4-OCHF₂) Ph(2-F,3-OCF₃,4-t-Bu) Ph(2-F,3-OCHF₂,4-TMS) Ph(2-F,3-CF₂H,4-OCF₂CF₂H) Ph(2-F,3-OCF₃,4-i-Pr) Ph(2-F,3-OCHF₂,4-CN) Ph(2-F,3-CF₂H,4-OCF₂CF₃) Ph(2-F,3-OCF₃,4-c-Pr) Ph(2-F,3-OCF₂CF₂H,4-Cl) Ph(2-F,3-CF₂H,4-SO₂Me) Ph(2-F,3-OCF₃,4-CF₃) Ph(2-F,3-OCF₂CF₂H,4-F) Ph(2-F,3-CF₂H,4-TMS) Ph(2-F,3-OCF₃,4-CF₂CF₃) Ph(2-F,3-OCF₂CF₂H,4-Br) Ph(2-F,3-CF₂H,4-CN) Ph(2-F,3-OCF₃,4-CF₂CF₂H) Ph(2-F,3-OCF₂CF₂H,4-I) Ph(2-F,3-OMe,4-Cl) Ph(2-F,3-OCF₃,4-CF₂H) Ph(2-F,3-OCF₂CF₂H,4-Me) Ph(2-F,3-OMe,4-F) Ph(2-F,3-OCF₃,4-OMe) Ph(2-F,3-OCF₂CF₂H,4-Ei) Ph(2-F,3-OMe,4-Br) Ph(2-F,3,4-di-OCF₃) Ph(2-F,3-OCF₂CF₂H,4-n-Pr) Ph(2-F,3-OMe,4-I) Ph(2-F,3-OCF₃,4-OCHF₂) Ph(2-F,3-OCF₂CF₂H,4-t-Bu) Ph(2-F,3-OMe,4-Me) Ph(2-F,3-OCF₃,4-OCF₂CF₂H) Ph(2-F,3-OCF₂CF₂H,4-i-Pr) Ph(2-F,3-OMe,4-Ei) Ph(2-F,3-OCF₃,4-OCF₂CF₃) Ph(2-F,3-OCF₂CF₂H,4-c-Pr) Ph(2-F,3-OMe,4-n-Pr) Ph(2-F,3-OCF₃,4-SO₂Me) Ph(2-F,3-OCF₂CF₂HCF₃,4-CF₃) Ph(2-F,3-OMe,4-t-Bu) Ph(2-F,3-OCF₃,4-TMS) Ph(2-F,3-OCF₂CF₂H,4-CF₂CF₃) Ph(2-F,3-OMe,4-i-Pr) Ph(2-F,3-OCF₃,4-CN) Ph(2-F,3-OCF₂CF₂H,4-CF₂CF₂H) Ph(2-F,3-OMe,4-c-Pr) Ph(2-F,3-OCHF₂,4-Cl) Ph(2-F,3-OCF₂CF₂H,4-CF₂H) Ph(2-F,3-OMeCF₃,4-CF₃) Ph(2-F,3-OCHF₂,4-F) Ph(2-F,3-OCF₂CF₂H,4-OMe) Ph(2-F,3-OMe,4-CF₂CF₃) Ph(2-F,3-OCHF₂,4-Br) Ph(2-F,3-OCF₂CF₂H,4-OCF₃) Ph(2-F,3-OMe,4-CF₂CF₂H) Ph(2-F,3-OCHF₂,4-I) Ph(2-F,3-OCF₂CF₂H,4-OCHF₂) Ph(2-F,3-OMe,4-CF₂H) Ph(2-F,3-OCHF₂,4-Me) Ph(2-F,3,4-di-OCF₂CF₂H) Ph(2-F,3,4-di-OMe) Ph(2-F,3-OCHF₂,4-Ei) Ph(2-F,3-OCF₂CF₂H,4-OCF₂CF₃) Ph(2-F,3-OMe,4-OCF₃) Ph(2-F,3-OCHF₂,4-n-Pr) Ph(2-F,3-OCF₂CF₃H,4-SO₂Me) Ph(2-F,3-OMe,4-OCHF₂) Ph(2-F,3-OCHF₂,4-t-Bu) Ph(2-F,3-OCF₂CF₂H,4-TMS) Ph(2-F,3-OMe,4-OCF₂CF₂H) Ph(2-F,3-OCHF₂,4-i-Pr) Ph(2-F,3-OCF₂CF₂H,4-CN) Ph(2-F,3-OMe,4-OCF₂CF₃) Ph(2-F,3-OCHF₂,4-c-Pr) Ph(2-F,3-OCF₂CF₃,4-Cl) Ph(2-F,3-OMe,4-SO₂Me) Ph(2-F,3-OCHF₂CF₃,4-CF₃) Ph(2-F,3-OCF₂CF₃,4-F) Ph(2-F,3-OMe,4-TMS) Ph(2-F,3-OCF₂CF₃,4-CF₂CF₃) Ph(2-F,3-OCF₂CF₃,4-Br) Ph(2-F,3-OMe,4-CN) Ph(2-F,3-OCHF₂,4-CF₂CF₂H) Ph(2-F,3-OCF₂CF₃,4-I) Ph(2-F,3-OCF₂CF₃,4-Me) Ph(2-F,3-SO₂Me,4-OCF₂CF₂H) Ph(2-F,3-CN,4-i-Pr) Ph(2-F,3-OCF₂CF₃,4-Ei) Ph(2-F,3-SO₂Me,4-OCF₂CF₃) Ph(2-F,3-CN,4-c-Pr) Ph(2-F,3-OCF₂CF₃,4-n-Pr) Ph(2-F,3,4-di-SO₂Me) Ph(2-F,3-CN,4-CF₃) Ph(2-F,3-OCF₂CF₃,4-t-Bu) Ph(2-F,3-SO₂Me,4-TMS) Ph(2-F,3-CN,4-CF₂CF₃) Ph(2-F,3-OCF₂CF₃,4-i-Pr) Ph(2-F,3-SO₂Me,4-CN) Ph(2-F,3-CN,4-CF₂CF₂H) Ph(2-F,3-OCF₂CF₃,4-c-Pr) Ph(2-F,3-TMS,4-C1) Ph(2-F,3-CN,4-CF₂H) Ph(2-F,3-OCF₂CF₃,CF₂,4-CF₃) Ph(2-F,3-TMS,4-F) Ph(2-F,3-CN,4-OMe) Ph(2-F,3-OCF₂CF₃,4-CF₂CF₃) Ph(2-F,3-TMS,4-Br) Ph(2-F,3-CN,4-OCF₃) Ph(2-F,3-OCF₂CF₃,4-CF₂CF₂H) Ph(2-F,3-TMS,4-I) Ph(2-F,3-CN,4-OCHF₂) Ph(2-F,3-OCF₂CF₃,4-CF₂H) Ph(2-F,3-TMS,4-Me) Ph(2-F,3-CN,4-OCF₂CF₂H) Ph(2-F,3-OCF₂CF₃,4-OMe) Ph(2-F,3-TMS,4-Ei) Ph(2-F,3-CN,4-OCF₂CF₂H) Ph(2-F,3-OCF₂CF₃,4-OCF₃) Ph(2-F,3-TMS,4-n-Pr) Ph(2-F,3-CN,4-SO₂Me) Ph(2-F,3-OCF₂CF₃,4-OCHF₂) Ph(2-F,3-TMS,4-t-Bu) Ph(2-F,3-CN,4-TMS) Ph(2-F,3-OCF₂CF₃,4-OCF₂CF₂H) Ph(2-F,3-TMS,4-i-Pr) Ph(2-F,3,4-di-CN) Ph(2-F,3,4-di-OCF₂CF₃) Ph(2-F,3-TMS,4-c-Pr) Ph(2-F,3,5-di-Cl) Ph(2-F,3-OCF₂CF₃,4-SO₂Me) Ph(2-F,3-TMS,4-CF₃) Ph(2-F,3-Cl,5-F) Ph(2-F,3-OCF₂CF₃,4-TMS) Ph(2-F,3-TMS,4-CF₂CF₃) Ph(2-F,3-Cl,5-Br) Ph(2-F,3-OCF₂CF₃,4-CN) Ph(2-F,3-TMS,4-CF₂CF₂H) Ph(2-F,3-Cl,5-I) Ph(2-F,3-SO₂Me,4-Cl) Ph(2-F,3-TMS,4-CF₂H) Ph(2-F,3-Cl,5-Me) Ph(2-F,3-SO₂Me,4-F) Ph(2-F,3-TMS,4-OMe) Ph(2-F,3-Cl,5-Et) Ph(2-F,3-SO₂Me,4-Br) Ph(2-F,3-TMS,4-OCF₃) Ph(2-F,3-Cl,5-n-Pr) Ph(2-F,3-SO₂Me,4-I) Ph(2-F,3-TMS,4-OCHF₂) Ph(2-F,3-Cl,5-t-Bu) Ph(2-F,3-SO₂Me,4-Me) Ph(2-F,3-TMS,4-OCF₂CF₂H) Ph(2-F,3-Cl,5-i-Pr) Ph(2-F,3-SO₂Me,4-Ei) Ph(2-F,3-TMS,4-OCF₂CF₃) Ph(2-F,3-Cl,5-c-Pr) Ph(2-F,3-SO₂Me,4-n-Pr) Ph(2-F,3-TMS,4-SO₂Me) Ph(2-F,3-Cl,5-CF₃) Ph(2-F,3-SO₂Me,4-t-Bu) Ph(2-F,3,4-di-TMS) Ph(2-F,3-C1,5-CF₂CF₃) Ph(2-F,3-SO₂Me,4-i-Pr) Ph(2-F,3-TMS,4-CN) Ph(2-F,3-Cl,5-CF₂CF₂H) Ph(2-F,3-SO₂Me,4-c-Pr) Ph(2-F,3-CN,4-C1) Ph(2-F,3-Cl,5-CF₂H) Ph(2-F,3-SO₂MeCF₃,4-CF₃) Ph(2-F,3-CN,4-F) Ph(2-F,3-Cl,5-OMe) Ph(2-F,3-SO₂Me,4-CF₂CF₃) Ph(2-F,3-CN,4-Br) Ph(2-F,3-Cl,5-OCF₃) Ph(2-F,3-SO₂Me,4-CF₂CF₂H) Ph(2-F,3-CN,4-I) Ph(2-F,3-Cl,5-OCHF₂) Ph(2-F,3-SO₂Me,4-CF₂H) Ph(2-F,3-CN,4-Me) Ph(2-F,3-Cl,5-OCF₂CF₂H) Ph(2-F,3-SO₂Me,4-OMe) Ph(2-F,3-CN,4-Ei) Ph(2-F,3-Cl,5-OCF₂CF₃) Ph(2-F,3-SO₂Me,4-OCF₃) Ph(2-F,3-CN,4-n-Pr) Ph(2-F,3-Cl,5-SO₂Me) Ph(2-F,3-SO₂Me,4-OCHF₂) Ph(2-F,3-CN,4-t-Bu) Ph(2-F,3-Cl,5-TMS) Ph(2-F,3-Cl,5-CN) Ph(2-F,3-Br,5-CF₂CF₂H) Ph(2-F,3-Me,5-I) Ph(2-F,3-F,5-Cl) Ph(2-F,3-Br,5-CF₂H) Ph(2-F,3,5-di-Me) Ph(2,3,5-tri-F) Ph(2-F,3-Br,5-OMe) Ph(2-F,3-Me,5-Et) Ph(2-F,3-F,5-Br) Ph(2-F,3-Br,5-OCF₃) Ph(2-F,3-Me,5-n-Pr) Ph(2-F,3-F,5-I) Ph(2-F,3-Br,5-OCHF₂) Ph(2-F,3-Me,5-t-Bu) Ph(2-F,3-F,5-Me) Ph(2-F,3-Br,5-OCF₂CF₂H) Ph(2-F,3-Me,5-i-Pr) Ph(2-F,3-F,5-Et) Ph(2-F,3-Br,5-OCF₂CF₃) Ph(2-F,3-Me,5-c-Pr) Ph(2-F,3-F,5-n-Pr) Ph(2-F,3-Br,5-SO₂Me) Ph(2-F,3-Me,5-CF₃) Ph(2-F,3-F,5-t-Bu) Ph(2-F,3-Br,5-TMS) Ph(2-F,3-Me,5-CF₂CF₃) Ph(2-F,3-F,5-i-Pr) Ph(2-F,3-Br,5-CN) Ph(2-F,3-Me,5-CF₂CF₂H) Ph(2-F,3-F,5-c-Pr) Ph(2-F,3-I,5-Cl) Ph(2-F,3-Me,5-CF₂H) Ph(2-F,3-F,5-CF₃) Ph(2-F,3-I,5-F) Ph(2-F,3-Me,5-OMe) Ph(2-F,3-F,5-CF₂CF₃) Ph(2-F,3-I,5-Br) Ph(2-F,3-Me,5-OCF₃) Ph(2-F,3-F,5-CF₂CF₂H) Ph(2-F,3,5-di-I) Ph(2-F,3-Me,5-OCHF₂) Ph(2-F,3-F,5-CF₂H) Ph(2-F,3-I,5-Me) Ph(2-F,3-Me,5-OCF₂CF₂H) Ph(2-F,3-F,5-OMe) Ph(2-F,3-I,5-Et) Ph(2-F,3-Me,5-OCF₂CF₃) Ph(2-F,3-F,5-OCF₃) Ph(2-F,3-I,5-n-Pr) Ph(2-F,3-Me,5-SO₂Me) Ph(2-F,3-F,5-OCHF₂) Ph(2-F,3-I,5-t-Bu) Ph(2-F,3-Me,5-TMS) Ph(2-F,3-F,5-OCF₂CF₂H) Ph(2-F,3-I,5-i-Pr) Ph(2-F,3-Me,5-CN) Ph(2-F,3-F,5-OCF₂CF₃) Ph(2-F,3-I,5-c-Pr) Ph(2-F,3-Et,5-Cl) Ph(2-F,3-F,5-SO₂Me) Ph(2-F,3-I,5-CF₃) Ph(2-F,3-Et,5-F) Ph(2-F,3-F,5-TMS) Ph(2-F,3-I,5-CF₂CF₃) Ph(2-F,3-Et,5-Br) Ph(2-F,3-F,5-CN) Ph(2-F,3-I,5-CF₂CF₂H) Ph(2-F,3-Et,5-I) Ph(2-F,3-Br,5-Cl) Ph(2-F,3-I,5-CF₂H) Ph(2-F,3-Et,5-Me) Ph(2-F,3-Br,5-F) Ph(2-F,3-I,5-OMe) Ph(2-F,3,5-di-Et) Ph(2-F,3,5-di-Br) Ph(2-F,34,5-OCF₃) Ph(2-F,3-Et,5-n-Pr) Ph(2-F,3-Br,5-I) Ph(2-F,34,5-OCHF₂) Ph(2-F,3-Et,5-t-Bu) Ph(2-F,3-Br,5-Me) Ph(2-F,34,5-OCF₂CF₂H) Ph(2-F,3-Et,5-i-Pr) Ph(2-F,3-Br,5-Et) Ph(2-F,34,5-OCF₂CF₃) Ph(2-F,3-Et,5-c-Pr) Ph(2-F,3-Br,5-n-Pr) Ph(2-F,3-I,5-SO₂Me) Ph(2-F,3-Et,5-CF₃) Ph(2-F,3-Br,5-t-Bu) Ph(2-F,3-I,5-TMS) Ph(2-F,3-Et,5-CF₂CF₃) Ph(2-F,3-Br,5-i-Pr) Ph(2-F,3-I,5-CN) Ph(2-F,3-Et,5-CF₂CF₂H) Ph(2-F,3-Br,5-c-Pr) Ph(2-F,3-Me,5-Cl) Ph(2-F,3-Et,5-CF₂H) Ph(2-F,3-Br,5-CF₃) Ph(2-F,3-Me,5-F) Ph(2-F,3-Et,5-OMe) Ph(2-F,3-Br,5-CF₂CF₃) Ph(2-F,3-Me,5-Br) Ph(2-F,3-Et,5-OCF₃) Ph(2-F,3-Et,5-OCHF₂) Ph(2-F,3,5-di-t-Bu) Ph(2-F,3-i-Pr,5-TMS) Ph(2-F,3-Et,5-OCF₂CF₂H) Ph(2-F,3-t-Bu,5-i-Pr) Ph(2-F,3-i-Pr,5-CN) Ph(2-F,3-Et,5-OCF₂CF₃) Ph(2-F,3-t-Bu,5-c-Pr) Ph(2-F,3-c-Pr,5-Cl) Ph(2-F,3-Et,5-SO₂Me) Ph(2-F,3-t-Bu,5-CF₃) Ph(2-F,3-c-Pr,5-F) Ph(2-F,3-Et,5-TMS) Ph(2-F,3-t-Bu,5-CF₂CF₃) Ph(2-F,3-c-Pr,5-Br) Ph(2-F,3-Et,5-CN) Ph(2-F,3-t-Bu,5-CF₂CF₂H) Ph(2-F,3-c-Pr,5-I) Ph(2-F,3-n-Pr,5-Cl) Ph(2-F,3-t-Bu,5-CF₂H) Ph(2-F,3-c-Pr,5-Me) Ph(2-F,3-n-Pr,5-F) Ph(2-F,3-t-Bu,5-OMe) Ph(2-F,3-c-Pr,5-Ei) Ph(2-F,3-n-Pr,5-Br) Ph(2-F,3-t-Bu,5-OCF₃) Ph(2-F,3-c-Pr,5-n-Pr) Ph(2-F,3-n-Pr,5-I) Ph(2-F,3-t-Bu,5-OCHF₂) Ph(2-F,3-c-Pr,5-t-Bu) Ph(2-F,3-n-Pr,5-Me) Ph(2-F,3-t-Bu,5-OCF₂CF₂H) Ph(2-F,3-c-Pr,5-i-Pr) Ph(2-F,3-n-Pr,5-Et) Ph(2-F,3-t-Bu,5-OCF₂CF₃) Ph(2-F,3,5-di-c-Pr) Ph(2-F,3,5-di-n-Pr) Ph(2-F,3-t-Bu,5-SO₂Me) Ph(2-F,3-c-Pr,5-CF₃) Ph(2-F,3-n-Pr,5-t-Bu) Ph(2-F,3-t-Bu,5-TMS) Ph(2-F,3-c-Pr,5-CF₂CF₃) Ph(2-F,3-n-Pr,5-i-Pr) Ph(2-F,3-t-Bu,5-CN) Ph(2-F,3-c-Pr,5-CF₂CF₂H) Ph(2-F,3-n-Pr,5-c-Pr) Ph(2-F,3-i-Pr,5-Cl) Ph(2-F,3-c-Pr,5-CF₂H) Ph(2-F,3-n-Pr,5-CF₃) Ph(2-F,3-i-Pr,5-F) Ph(2-F,3-c-Pr,5-OMe) Ph(2-F,3-n-Pr,5-CF₂CF₃) Ph(2-F,3-i-Pr,5-Br) Ph(2-F,3-c-Pr,5-OCF₃) Ph(2-F,3-n-Pr,5-CF₂CF₂H) Ph(2-F,3-i-Pr,5-I) Ph(2-F,3-c-Pr,5-OCHF₂) Ph(2-F,3-n-Pr,5-CF₂H) Ph(2-F,3-i-Pr,5-Me) Ph(2-F,3-c-Pr,5-OCF₂CF₂H) Ph(2-F,3-n-Pr,5-OMe) Ph(2-F,3-i-Pr,5-Ei) Ph(2-F,3-c-Pr,5-OCF₂CF₃) Ph(2-F,3-n-Pr,5-OCF₃) Ph(2-F,3-i-Pr,5-n-Pr) Ph(2-F,3-c-Pr,5-SO₂Me) Ph(2-F,3-n-Pr,5-OCHF₂) Ph(2-F,3-i-Pr,5-t-Bu) Ph(2-F,3-c-Pr,5-TMS) Ph(2-F,3-n-Pr,5-OCF₂CF₂H) Ph(2-F,3,5-di-i-Pr) Ph(2-F,3-c-Pr,5-CN) Ph(2-F,3-n-Pr,5-OCF₂CF₃) Ph(2-F,3-i-Pr,5-c-Pr) Ph(2-F,3-CF₃,5-Cl) Ph(2-F,3-n-Pr,5-SO₂Me) Ph(2-F,3-i-Pr,5-CF₃) Ph(2-F,3-CF₃,5-F) Ph(2-F,3-n-Pr,5-TMS) Ph(2-F,3-i-Pr,5-CF₂CF₃) Ph(2-F,3-CF₃,5-Br) Ph(2-F,3-n-Pr,5-CN) Ph(2-F,3-i-Pr,5-CF₂CF₂H) Ph(2-F,3-CF₃,5-I) Ph(2-F,3-t-Bu,5-Cl) Ph(2-F,3-i-Pr,5-CF₂H) Ph(2-F,3-CF₃,5-Me) Ph(2-F,3-t-Bu,5-F) Ph(2-F,3-i-Pr,5-OMe) Ph(2-F,3-CF₃,5-Ei) Ph(2-F,3-t-Bu,5-Br) Ph(2-F,3-i-Pr,5-OCF₃) Ph(2-F,3-CF₃,5-n-Pr) Ph(2-F,3-t-Bu,5-I) Ph(2-F,3-i-Pr,5-OCHF₂) Ph(2-F,3-CF₃,5-t-Bu) Ph(2-F,3-t-Bu,5-Me) Ph(2-F,3-i-Pr,5-OCF₂CF₂H) Ph(2-F,3-CF₃,5-i-Pr) Ph(2-F,3-t-Bu,5-Et) Ph(2-F,3-i-Pr,5-OCF₂CF₃) Ph(2-F,3-CF₃,5-c-Pr) Ph(2-F,3-t-Bu,5-n-Pr) Ph(2-F,3-i-Pr,5-SO₂Me) Ph(2-F,3,5-di-CF₃) Ph(2-F,3-CF₃,5-CF₂CF₃) Ph(2-F,3-CF₂CF₂H,5-Br) Ph(2-F,3-CF₂H,5-OCF₃) Ph(2-F,3-CF₃,5-CF₂CF₂H) Ph(2-F,3-CF₂CF₂H,5-I) Ph(2-F,3-CF₂H,5-OCHF₂) Ph(2-F,3-CF₃,5-CF₂H) Ph(2-F,3-CF₂CF₂H,5-Me) Ph(2-F,3-CF₂H,5-OCF₂CF₂H) Ph(2-F,3-CF₃,5-OMe) Ph(2-F,3-CF₂CF₂H,5-Ei) Ph(2-F,3-CF₂H,5-OCF₂CF₃) Ph(2-F,3-CF₃,5-OCF₃) Ph(2-F,3-CF₂CF₂H,5-n-Pr) Ph(2-F,3-CF₂H,5-SO₂Me) Ph(2-F,3-CF₃,5-OCHF₂) Ph(2-F,3-CF₂CF₂H,5-t-Bu) Ph(2-F,3-CF₂H,5-TMS) Ph(2-F,3-CF₃,5-OCF₂CF₂H) Ph(2-F,3-CF₂CF₂H,5-i-Pr) Ph(2-F,3-CF₂H,5-CN) Ph(2-F,3-CF₃,5-OCF₂CF₃) Ph(2-F,3-CF₂CF₂H,5-c-Pr) Ph(2-F,3-OMe,5-Cl) Ph(2-F,3-CF₃,5-SO₂Me) Ph(2-F,3-CF₂CF₂HCF₃,5-CF₃) Ph(2-F,3-OMe,5-F) Ph(2-F,3-CF₃,5-IMS) Ph(2-F,3-CF₂CF₂H,5-CF₂CF₃) Ph(2-F,3-OMe,5-Br) Ph(2-F,3-CF₃,5-CN) Ph(2-F,3,5-di-CF₂CF₂H) Ph(2-F,3-OMe,5-I) Ph(2-F,3-CF₂CF₃,5-Cl) Ph(2-F,3-CF₂CF₂H,5-CF₂H) Ph(2-F,3-OMe,5-Me) Ph(2-F,3-CF₂CF₃,5-F) Ph(2-F,3-CF₂CF₂H,5-OMe) Ph(2-F,3-OMe,5-Ei) Ph(2-F,3-CF₂CF₃,5-Br) Ph(2-F,3-CF₂CF₂H,5-OCF₃) Ph(2-F,3-OMe,5-n-Pr) Ph(2-F,3-CF₂CF₃,5-I) Ph(2-F,3-CF₂CF₂H,5-OCHF₂) Ph(2-F,3-OMe,5-t-Bu) Ph(2-F,3-CF₂CF₃,5-Me) Ph(2-F,3-CF₂CF₂H,5-OCF₂CF₂H) Ph(2-F,3-OMe,5-i-Pr) Ph(2-F,3-CF₂CF₃,5-Ei) Ph(2-F,3-CF₂CF₂H,5-OCF₂CF₃) Ph(2-F,3-OMe,5-c-Pr) Ph(2-F,3-CF₂CF₃,5-n-Pr) Ph(2-F,3-CF₂CF₂H,5-SO₂Me) Ph(2-F,3-OMeCF₃,5-CF₃) Ph(2-F,3-CF₂CF₃,5-t-Bu) Ph(2-F,3-CF₂CF₂H,5-TMS) Ph(2-F,3-OMe,5-CF₂CF₃) Ph(2-F,3-CF₂CF₃,5-i-Pr) Ph(2-F,3-CF₂CF₂H,5-CN) Ph(2-F,3-OMe,5-CF₂CF₂H) Ph(2-F,3-CF₂CF₃,5-c-Pr) Ph(2-F,3-CF₂H,5-Cl) Ph(2-F,3-OMe,5-CF₂H) Ph(2-F,3-CF₂CF₃CF₃,5-CF₃) Ph(2-F,3-CF₂H,5-F) Ph(2-F,3,5-di-OMe) Ph(2-F,3,5-di-CF₂CF₃) Ph(2-F,3-CF₂H,5-Br) Ph(2-F,3-OMe,5-OCF₃) Ph(2-F,3-CF₂CF₃,5-CF₂CF₂H) Ph(2-F,3-CF₂H,5-I) Ph(2-F,3-OMe,5-OCHF₂) Ph(2-F,3-CF₂CF₃,5-CF₂H) Ph(2-F,3-CF₂H,5-Me) Ph(2-F,3-OMe,5-OCF₂CF₂H) Ph(2-F,3-CF₂CF₃,5-OMe) Ph(2-F,3-CF₂H,5-Ei) Ph(2-F,3-OMe,5-OCF₂CF₃) Ph(2-F,3-CF₂CF₃, 5-OCF₃) Ph(2-F,3-CF₂H,5-n-Pr) Ph(2-F,3-OMe,5-SO₂Me) Ph(2-F,3-CF₂CF₃, 5-OCHF₂) Ph(2-F,3-CF₂H,5-t-Bu) Ph(2-F,3-OMe,5-TMS) Ph(2-F,3-CF₂CF₃,5-OCF₂CF₂H) Ph(2-F,3-CF₂H,5-i-Pr) Ph(2-F,3-OMe,5-CN) Ph(2-F,3-CF₂CF₃,5-OCF₂CF₃) Ph(2-F,3-CF₂H,5-c-Pr) Ph(2-F,3-OCF₃,5-Cl) Ph(2-F,3-CF₂CF₃,5-SO₂Me) Ph(2-F,3-CF₂H,5-CF₃) Ph(2-F,3-OCF₃,5-F) Ph(2-F,3-CF₂CF₃,5-TMS) Ph(2-F,3-CF₂H,5-CF₂CF₃) Ph(2-F,3-OCF₃,5-Br) Ph(2-F,3-CF₂CF₃,5-CN) Ph(2-F,3-CF₂H,5-CF₂CF₂H) Ph(2-F,3-OCF₃,5-I) Ph(2-F,3-CF₂CF₂H,5-Cl) Ph(2-F,3,5-di-CF₂H) Ph(2-F,3-OCF₃,5-Me) Ph(2-F,3-CF₂CF₂H,5-F) Ph(2-F,3-CF₂H,5-OMe) Ph(2-F,3-OCF₃,5-Ei) Ph(2-F,3-OCF₃,5-n-Pr) Ph(2-F,3-OCHF₂,5-SO₂Me) Ph(2-F,3-OCF₂CF₃CF₃,5-CF₃) Ph(2-F,3-OCF₃,5-t-Bu) Ph(2-F,3-OCHF₂,5-TMS) Ph(2-F,3-OCF₂CF₃,5-CF₂CF₃) Ph(2-F,3-OCF₃,5-i-Pr) Ph(2-F,3-OCHF₂,5-CN) Ph(2-F,3-OCF₂CF₃,5-CF₂CF₂H) Ph(2-F,3-OCF₃,5-c-Pr) Ph(2-F,3-OCF₂CF₂H,5-Cl) Ph(2-F,3-OCF₂CF₃,5-CF₂H) Ph(2-F,3-OCF₃,5-CF₃) Ph(2-F,3-OCF₂CF₂H,5-F) Ph(2-F,3-OCF₂CF₃,5-OMe) Ph(2-F,3-OCF₃,5-CF₂CF₃) Ph(2-F,3-OCF₂CF₂H,5-Br) Ph(2-F,3-OCF₂CF₃,5-OCF₃) Ph(2-F,3-OCF₃,5-CF₂CF₂H) Ph(2-F,3-OCF₂CF₂H,5-I) Ph(2-F,3-OCF₂CF₃,5-OCHF₂) Ph(2-F,3-OCF₃,5-CF₂H) Ph(2-F,3-OCF₂CF₂H,5-Me) Ph(2-F,3-OCF₂CF₃,5-OCF₂CF₂H) Ph(2-F,3-OCF₃,5-OMe) Ph(2-F,3-OCF₂CF₂H,5-Ei) Ph(2-F,3,5-di-OCF₂CF₃) Ph(2-F,3,5-di-OCF₃) Ph(2-F,3-OCF₂CF₂H,5-n-Pr) Ph(2-F,3-OCF₂CF₃,5-SO₂Me) Ph(2-F,3-OCF₃,5-OCHF₂) Ph(2-F,3-OCF₂CF₂H,5-t-Bu) Ph(2-F,3-OCF₂CF₃,5-TMS) Ph(2-F,3-OCF₃,5-OCF₂CF₂H) Ph(2-F,3-OCF₂CF₂H,5-i-Pr) Ph(2-F,3-OCF₂CF₃,5-CN) Ph(2-F,3-OCF₃,5-OCF₂CF₃) Ph(2-F,3-OCF₂CF₂H,5-c-Pr) Ph(2-F,3-SO₂Me,5-Cl) Ph(2-F,3-OCF₃,5-SO₂Me) Ph(2-F,3-OCF₂CF₂HCF₃,5-CF₃) Ph(2-F,3-SO₂Me,5-F) Ph(2-F,3-OCF₃,5-TMS) Ph(2-F,3-OCF₂CF₂H,5-CF₂CF₃) Ph(2-F,3-SO₂Me,5-Br) Ph(2-F,3-OCF₃,5-CN) Ph(2-F,3-OCF₂CF₂H,5-CF₂CF₂H) Ph(2-F,3-SO₂Me,5-I) Ph(2-F,3-OCHF₂,5-Cl) Ph(2-F,3-OCF₂CF₂H,5-CF₂H) Ph(2-F,3-SO₂Me,5-Me) Ph(2-F,3-OCHF₂,5-F) Ph(2-F,3-OCF₂CF₂H,5-OMe) Ph(2-F,3-SO₂Me,5-Ei) Ph(2-F,3-OCHF₂,5-Br) Ph(2-F,3-OCF₂CF₂H,5-OCF₃) Ph(2-F,3-SO₂Me,5-n-Pr) Ph(2-F,3-OCHF₂,5-I) Ph(2-F,3-OCF₂CF₂H,5-OCHF₂) Ph(2-F,3-SO₂Me,5-t-Bu) Ph(2-F,3-OCHF₂,5-Me) Ph(2-F,3,5-di-OCF₂CF₂H) Ph(2-F,3-SO₂Me,5-i-Pr) Ph(2-F,3-OCHF₂,5-Ei) Ph(2-F,3-OCF₂CF₂H,5-OCF₂CF₃) Ph(2-F,3-SO₂Me,5-c-Pr) Ph(2-F,3-OCHF₂,5-n-Pr) Ph(2-F,3-OCF₂CF₂H,5-SO₂Me) Ph(2-F,3-SO₂MeCF₃,5-CF₃) Ph(2-F,3-OCHF₂,5-t-Bu) Ph(2-F,3-OCF₂CF₂H,5-TMS) Ph(2-F,3-SO₂Me,5-CF₂CF₃) Ph(2-F,3-OCHF₂,5-i-Pr) Ph(2-F,3-OCF₂CF₂H,5-CN) Ph(2-F,3-SO₂Me,5-CF₂CF₂H) Ph(2-F,3-OCHF₂,5-c-Pr) Ph(2-F,3-OCF₂CF₃,5-Cl) Ph(2-F,3-SO₂Me,5-CF₂H) Ph(2-F,3-OCHF₂CF₃,5-CF₃) Ph(2-F,3-OCF₂CF₃,5-F) Ph(2-F,3-SO₂Me,5-OMe) Ph(2-F,3-OCF₂CF₃,5-CF₂CF₃) Ph(2-F,3-OCF₂CF₃,5-Br) Ph(2-F,3-SO₂Me,5-OCF₃) Ph(2-F,3-OCHF₂,5-CF₂CF₂H) Ph(2-F,3-OCF₂CF₃,5-I) Ph(2-F,3-SO₂Me,5-OCHF₂) Ph(2-F,3-OCHF₂,5-CF₂H) Ph(2-F,3-OCF₂CF₃,5-Me) Ph(2-F,3-SO₂Me,5-OCF₂CF₂H) Ph(2-F,3-OCHF₂,5-OMe) Ph(2-F,3-OCF₂CF₃,5-Ei) Ph(2-F,3-SO₂Me,5-OCF₂CF₃) Ph(2-F,3-OCHF₂,5-OCF₃) Ph(2-F,3-OCF₂CF₃,5-n-Pr) Ph(2-F,3,5-di-SO₂Me) Ph(2-F,3,5-di-OCHF₂) Ph(2-F,3-OCF₂CF₃,5-t-Bu) Ph(2-F,3-SO₂Me,5-TMS) Ph(2-F,3-OCHF₂,5-OCF₂CF₂H) Ph(2-F,3-OCF₂CF₃,5-i-Pr) Ph(2-F,3-SO₂Me,5-CN) Ph(2-F,3-OCHF₂,5-OCF₂CF₃) Ph(2-F,3-OCF₂CF₃,5-c-Pr) Ph(2-F,3-TMS,5-Cl) Ph(2-F,3-TMS,5-F) Ph(2-F,3-CN,5-OMe) Ph(2-F,4-F,5-Et) Ph(2-F,3-TMS,5-Br) Ph(2-F,3-CN,5-OCF₃) Ph(2-F,4-F,5-n-Pr) Ph(2-F,3-TMS,5-I) Ph(2-F,3-CN,5-OCHF₂) Ph(2-F,4-F,5-t-Bu) Ph(2-F,3-TMS,5-Me) Ph(2-F,3-CN,5-OCF₂CF₂H) Ph(2-F,4-F,5-i-Pr) Ph(2-F,3-TMS,5-Ei) Ph(2-F,3-CN,5-OCF₂CF₃) Ph(2-F,4-F,5-c-Pr) Ph(2-F,3-TMS,5-n-Pr) Ph(2-F,3-CN,5-SO₂Me) Ph(2-F,4-F,5-CF₃) Ph(2-F,3-TMS,5-t-Bu) Ph(2-F,3-CN,5-TMS) Ph(2-F,4-F,5-CF₂CF₃) Ph(2-F,3-TMS,5-i-Pr) Ph(2-F,3,5-di-CN) Ph(2-F,4-F,5-CF₂CF₂H) Ph(2-F,3-TMS,5-c-Pr) Ph(2-F,4,5-di-Cl) Ph(2-F,4-F,5-CF₂H) Ph(2-F,3-TMS,5-CF₃) Ph(2-F,4-Cl,5-F) Ph(2-F,4-F,5-OMe) Ph(2-F,3-TMS,5-CF₂CF₃) Ph(2-F,4-Cl,5-Br) Ph(2-F,4-F,5-OCF₃) Ph(2-F,3-TMS,5-CF₂CF₂H) Ph(2-F,4-Cl,5-I) Ph(2-F,4-F,5-OCHF₂) Ph(2-F,3-TMS,5-CF₂H) Ph(2-F,4-Cl,5-Me) Ph(2-F,4-F,5-OCF₂CF₂H) Ph(2-F,3-TMS,5-OMe) Ph(2-F,4-Cl,5-Et) Ph(2-F,4-F,5-OCF₂CF₃) Ph(2-F,3-TMS,5-OCF₃) Ph(2-F,4-Cl,5-n-Pr) Ph(2-F,4-F,5-SO₂Me) Ph(2-F,3-TMS,5-OCHF₂) Ph(2-F,4-Cl,5-t-Bu) Ph(2-F,4-F,5-TMS) Ph(2-F,3-TMS,5-OCF₂CF₂H) Ph(2-F,4-Cl,5-i-Pr) Ph(2-F,4-F,5-CN) Ph(2-F,3-TMS,5-OCF₂CF₃) Ph(2-F,4-Cl,5-c-Pr) Ph(2-F,4-Br,5-Cl) Ph(2-F,3-TMS,5-SO₂Me) Ph(2-F,4-Cl,5-CF₃) Ph(2-F,4-Br,5-F) Ph(2-F,3,5-di-TMS) Ph(2-F,4-Cl,5-CF₂CF₃) Ph(2-F,4,5-di-Br) Ph(2-F,3-TMS,5-CN) Ph(2-F,4-Cl,5-CF₂CF₂H) Ph(2-F,4-Br,5-I) Ph(2-F,3-CN,5-Cl) Ph(2-F,4-Cl,5-CF₂H) Ph(2-F,4-Br,5-Me) Ph(2-F,3-CN,5-F) Ph(2-F,4-Cl,5-OMe) Ph(2-F,4-Br,5-Et) Ph(2-F,3-CN,5-Br) Ph(2-F,4-Cl,5-OCF₃) Ph(2-F,4-Br,5-n-Pr) Ph(2-F,3-CN,5-I) Ph(2-F,4-Cl,5-OCHF₂) Ph(2-F,4-Br,5-t-Bu) Ph(2-F,3-CN,5-Me) Ph(2-F,4-Cl,5-OCF₂CF₂H) Ph(2-F,4-Br,5-i-Pr) Ph(2-F,3-CN,5-Ei) Ph(2-F,4-Cl,5-OCF₂CF₃) Ph(2-F,4-Br,5-c-Pr) Ph(2-F,3-CN,5-n-Pr) Ph(2-F,4-Cl,5-SO₂Me) Ph(2-F,4-Br,5-CF₃) Ph(2-F,3-CN,5-t-Bu) Ph(2-F,4-Cl,5-TMS) Ph(2-F,4-Br,5-CF₂CF₃) Ph(2-F,3-CN,5-i-Pr) Ph(2-F,4-Cl,5-CN) Ph(2-F,4-Br,5-CF₂CF₂H) Ph(2-F,3-CN,5-c-Pr) Ph(2-F,4-F,5-Cl) Ph(2-F,4-Br,5-CF₂H) Ph(2-F,3-CN,5-CF₃) Ph(2,4,5-tri-F) Ph(2-F,4-Br,5-OMe) Ph(2-F,3-CN,5-CF₂CF₃) Ph(2-F,4-F,5-Br) Ph(2-F,4-Br,5-OCF₃) Ph(2-F,3-CN,5-CF₂CF₂H) Ph(2-F,4-F,5-I) Ph(2-F,4-Br,5-OCHF₂) Ph(2-F,3-CN,5-CF₂H) Ph(2-F,4-F,5-Me) Ph(2-F,4-Br,5-OCF₂CF₂H) Ph(2-F,4-Br,5-OCF₂CF₃) Ph(2-F,4-Me,5-c-Pr) Ph(2-F,4-n-Pr,5-C1) Ph(2-F,4-Br,5-SO₂Me) Ph(2-F,4-Me,5-CF₃) Ph(2-F,4-n-Pr,5-F) Ph(2-F,4-Br,5-TMS) Ph(2-F,4-Me,5-CF₂CF₃) Ph(2-F,4-n-Pr,5-Br) Ph(2-F,4-Br,5-CN) Ph(2-F,4-Me,5-CF₂CF₂H) Ph(2-F,4-n-Pr,5-I) Ph(2-F,4-I,5-Cl) Ph(2-F,4-Me,5-CF₂H) Ph(2-F,4-n-Pr,5-Me) Ph(2-F,4-I,5-F) Ph(2-F,4-Me,5-OMe) Ph(2-F,4-n-Pr,5-Et) Ph(2-F,4-I,5-Br) Ph(2-F,4-Me,5-OCF₃) Ph(2-F,4,5-di-n-Pr) Ph(2-F,4,5-di-I) Ph(2-F,4-Me,5-OCHF₂) Ph(2-F,4-n-Pr,5-t-Bu) Ph(2-F,4-I,5-Me) Ph(2-F,4-Me,5-OCF₂CF₂H) Ph(2-F,4-n-Pr,5-i-Pr) Ph(2-F,4-I,5-Et) Ph(2-F,4-Me,5-OCF₂CF₃) Ph(2-F,4-n-Pr,5-c-Pr) Ph(2-F,4-I,5-n-Pr) Ph(2-F,4-Me,5-SO₂Me) Ph(2-F,4-n-Pr,5-CF₃) Ph(2-F,4-I,5-t-Bu) Ph(2-F,4-Me,5-TMS) Ph(2-F,4-n-Pr,5-CF₂CF₃) Ph(2-F,4-I,5-i-Pr) Ph(2-F,4-Me,5-CN) Ph(2-F,4-n-Pr,5-CF₂CF₂H) Ph(2-F,4-I,5-c-Pr) Ph(2-F,4-Et,5-Cl) Ph(2-F,4-n-Pr,5-CF₂H) Ph(2-F,4-I,5-CF₃) Ph(2-F,4-Et,5-F) Ph(2-F,4-n-Pr,5-OMe) Ph(2-F,4-I,5-CF₂CF₃) Ph(2-F,4-Et,5-Br) Ph(2-F,4-n-Pr,5-OCF₃) Ph(2-F,4-I,5-CF₂CF₂H) Ph(2-F,4-Et,5-I) Ph(2-F,4-n-Pr,5-OCHF₂) Ph(2-F,4-I,5-CF₂H) Ph(2-F,4-Et,5-Me) Ph(2-F,4-n-Pr,5-OCF₂CF₂H) Ph(2-F,4-I,5-OMe) Ph(2-F,4,5-di-Et) Ph(2-F,4-n-Pr,5-OCF₂CF₃) Ph(2-F,4-I,5-OCF₃) Ph(2-F,4-Et,5-n-Pr) Ph(2-F,4-n-Pr,5-SO₂Me) Ph(2-F,4-I,5-OCHF₂) Ph(2-F,4-Et,5-t-Bu) Ph(2-F,4-n-Pr,5-TMS) Ph(2-F,4-I,5-OCF₂CF₂H) Ph(2-F,4-Et,5-i-Pr) Ph(2-F,4-n-Pr,5-CN) Ph(2-F,4-I,5-OCF₂CF₃) Ph(2-F,4-Et,5-c-Pr) Ph(2-F,4-t-Bu,5-Cl) Ph(2-F,4-I,5-SO₂Me) Ph(2-F,4-Et,5-CF₃) Ph(2-F,4-t-Bu,5-F) Ph(2-F,4-I,5-TMS) Ph(2-F,4-Et,5-CF₂CF₃) Ph(2-F,4-t-Bu,5-Br) Ph(2-F,4-I,5-CN) Ph(2-F,4-Et,5-CF₂CF₂H) Ph(2-F,4-t-Bu,5-I) Ph(2-F,4-Me,5-Cl) Ph(2-F,4-Et,5-CF₂H) Ph(2-F,4-t-Bu,5-Me) Ph(2-F,4-Me,5-F) Ph(2-F,4-Et,5-OMe) Ph(2-F,4-t-Bu,5-Et) Ph(2-F,4-Me,5-Br) Ph(2-F,4-Et,5-OCF₃) Ph(2-F,4-t-Bu,5-n-Pr) Ph(2-F,4-Me,5-I) Ph(2-F,4-Et,5-OCHF₂) Ph(2-F,4,5-di-t-Bu) Ph(2-F,4,5-di-Me) Ph(2-F,4-Et,5-OCF₂CF₂H) Ph(2-F,4-t-Bu,5-i-Pr) Ph(2-F,4-Me,5-Et) Ph(2-F,4-Et,5-OCF₂CF₃) Ph(2-F,4-t-Bu,5-c-Pr) Ph(2-F,4-Me,5-n-Pr) Ph(2-F,4-Et,5-SO₂Me) Ph(2-F,4-t-Bu,5-CF₃) Ph(2-F,4-Me,5-t-Bu) Ph(2-F,4-Et,5-TMS) Ph(2-F,4-t-Bu,5-CF₂CF₃) Ph(2-F,4-Me,5-i-Pr) Ph(2-F,4-Et,5-CN) Ph(2-F,4-t-Bu,5-CF₂CF₂H) Ph(2-F,4-t-Bu,5-CF₂H) Ph(2-F,4-c-Pr,5-Me) Ph(2-F,4-CF₃,5-OCF₂CF₂H) Ph(2-F,4-t-Bu,5-OMe) Ph(2-F,4-c-Pr,5-Ei) Ph(2-F,4-CF₃,5-OCF₂CF₃) Ph(2-F,4-t-Bu,5-OCF₃) Ph(2-F,4-c-Pr,5-n-Pr) Ph(2-F,4-CF₃,5-SO₂Me) Ph(2-F,4-t-Bu,5-OCHF₂) Ph(2-F,4-c-Pr,5-t-Bu) Ph(2-F,4-CF₃,5-IMS) Ph(2-F,4-t-Bu,5-OCF₂CF₂H) Ph(2-F,4-c-Pr,5-i-Pr) Ph(2-F,4-CF₃,5-CN) Ph(2-F,4-t-Bu,5-OCF₂CF₃) Ph(2-F,4,5-di-c-Pr) Ph(2-F,4-CF₂CF₃,5-Cl) Ph(2-F,4-t-Bu,5-SO₂Me) Ph(2-F,4-c-Pr,5-CF₃) Ph(2-F,4-CF₂CF₃,5-F) Ph(2-F,4-t-Bu,5-TMS) Ph(2-F,4-c-Pr,5-CF₂CF₃ Ph(2-F,4-CF₂CF₃,5-Br) Ph(2-F,4-t-Bu,5-CN) Ph(2-F,4-c-Pr,5-CF₂CF₂H) Ph(2-F,4-CF₂CF₃,5-I) Ph(2-F,4-i-Pr,5-Cl) Ph(2-F,4-c-Pr,5-CF₂H) Ph(2-F,4-CF_(2l CF3),5-Me) Ph(2-F,4-i-Pr,5-F) Ph(2-F,4-c-Pr,5-OMe) Ph(2-F,4-CF₂CF₃,5-Ei) Ph(2-F,4-i-Pr,5-Br) Ph(2-F,4-c-Pr,5-OCF₃) Ph(2-F,4-CF₂CF₃,5-n-Pr) Ph(2-F,4-i-Pr,5-I) Ph(2-F,4-c-Pr,5-OCHF₂) Ph(2-F,4-CF₂CF₃,5-t-Bu) Ph(2-F,4-i-Pr,5-Me) Ph(2-F,4-c-Pr,5-OCF₂CF₂H) Ph(2-F,4-CF₂CF₃,5-i-Pr) Ph(2-F,4-i-Pr,5-Ei) Ph(2-F,4-c-Pr,5-OCF₂CF₃) Ph(2-F,4-CF₂CF₃,5-c-Pr) Ph(2-F,4-i-Pr,5-n-Pr) Ph(2-F,4-c-Pr,5-SO₂Me) Ph(2-F,4-CF₂CF₃CF₃,5-CF₃) Ph(2-F,4-i-Pr,5-t-Bu) Ph(2-F,4-c-Pr,5-TMS) Ph(2-F,4,5-di-CF₂CF₃) Ph(2-F,4,5-di-i-Pr) Ph(2-F,4-c-Pr,5-CN) Ph(2-F,4-CF₂CF₃,5-CF₂CF₂H) Ph(2-F,4-i-Pr,5-c-Pr) Ph(2-F,4-CF₃,5-Cl) Ph(2-F,4-CF₂CF₃,5-CF₂H) Ph(2-F,4-i-Pr,5-CF₃) Ph(2-F,4-CF₃,5-F) Ph(2-F,4-CF₂CF₃,5-OMe) Ph(2-F,4-i-Pr,5-CF₂CF₃) Ph(2-F,4-CF₃,5-Br) Ph(2-F,4-CF₂CF₃,5-OCF₃) Ph(2-F,4-i-Pr,5-CF₂CF₂H) Ph(2-F,4-CF₃,5-I) Ph(2-F,4-CF₂CF₃,5-OCHF₂) Ph(2-F,4-i-Pr,5-CF₂H) Ph(2-F,4-CF₃,5-Me) Ph(2-F,4-CF₂CF₃,5-OCF₂CF₂H) Ph(2-F,4-i-Pr,5-OMe) Ph(2-F,4-CF₃,5-Ei) Ph(2-F,4-CF₂CF₃,5-OCF₂CF₃) Ph(2-F,4-i-Pr,5-OCF₃) Ph(2-F,4-CF₃,5-n-Pr) Ph(2-F,4-CF₂CF₃,5-SO₂Me) Ph(2-F,4-i-Pr,5-OCHF₂) Ph(2-F,4-CF₃,5-t-Bu) Ph(2-F,4-CF₂CF₃,5-TMS) Ph(2-F,4-i-Pr,5-OCF₂CF₂H) Ph(2-F,4-CF₃,5-i-Pr) Ph(2-F,4-CF₂CF₃,5-CN) Ph(2-F,4-i-Pr,5-OCF₂CF₃) Ph(2-F,4-CF₃,5-c-Pr) Ph(2-F,4-CF₂CF₂H,5-Cl) Ph(2-F,4-i-Pr,5-SO₂Me) Ph(2-F,4,5-di-CF₃) Ph(2-F,4-CF₂CF₂H,5-F) Ph(2-F,4-i-Pr,5-TMS) Ph(2-F,4-CF₃,5-CF₂CF₃) Ph(2-F,4-CF₂CF₂H,5-Br) Ph(2-F,4-i-Pr,5-CN) Ph(2-F,4-CF₃,5-CF₂CF₂H) Ph(2-F,4-CF₂CF₂H,5-I) Ph(2-F,4-c-Pr,5-Cl) Ph(2-F,4-CF₃,5-CF₂H) Ph(2-F,4-CF₂CF₂H,5-Me) Ph(2-F,4-c-Pr,5-F) Ph(2-F,4-CF₃,5-OMe) Ph(2-F,4-CF₂CF₂H,5-Ei) Ph(2-F,4-c-Pr,5-Br) Ph(2-F,4-CF₃,5-OCF₃) Ph(2-F,4-CF₂CF₂H,5-n-Pr) Ph(2-F,4-c-Pr,5-I) Ph(2-F,4-CF₃,5-OCHF₂) Ph(2-F,4-CF₂CF₂H,5-t-Bu) Ph(2-F,4-CF₂CF₂H,5-i-Pr) Ph(2-F,4-CF₂H,5-CN) Ph(2-F,4-OCF₃,5-CF₂CF₂H) Ph(2-F,4-CF₂CF₂H,5-c-Pr) Ph(2-F,4-OMe,5-C1) Ph(2-F,4-OCF₃,5-CF₂H) Ph(2-F,4-CF₂CF₂HCF₃,5-CF₃) Ph(2-F,4-OMe,5-F) Ph(2-F,4-OCF₃,5-OMe) Ph(2-F,4-CF₂CF₂H,5-CF₂CF₃) Ph(2-F,4-OMe,5-Br) Ph(2-F,4,5-di-OCF₃) Ph(2-F,4,5-di-CF₂CF₂H) Ph(2-F,4-OMe,5-I) Ph(2-F,4-OCF₃,5-OCHF₂) Ph(2-F,4-CF₂CF₂H,5-CF₂H) Ph(2-F,4-OMe,5-Me) Ph(2-F,4-OCF₃,5-OCF₂CF₂H) Ph(2-F,4-CF₂CF₂H,5-OMe) Ph(2-F,4-OMe,5-Ei) Ph(2-F,4-OCF₃,5-OCF₂CF₃) Ph(2-F,4-CF₂CF₂H,5-OCF₃) Ph(2-F,4-OMe,5-n-Pr) Ph(2-F,4-OCF₃,5-SO₂Me) Ph(2-F,4-CF₂CF₂H,5-OCHF₂) Ph(2-F,4-OMe,5-t-Bu) Ph(2-F,4-OCF₃,5-TMS) Ph(2-F,4-CF₂CF₂H,5-OCF₂CF₂H) Ph(2-F,4-OMe,5-i-Pr) Ph(2-F,4-OCF₃,5-CN) Ph(2-F,4-CF₂CF₂H,5-OCF₂CF₃) Ph(2-F,4-OMe,5-c-Pr) Ph(2-F,4-OCHF₂,5-Cl) Ph(2-F,4-CF₂CF₂H,5-SO₂Me) Ph(2-F,4-OMeCF₃,5-CF₃) Ph(2-F,4-OCHF₂,5-F) Ph(2-F,4-CF₂CF₂H,5-TMS) Ph(2-F,4-OMe,5-CF₂CF₃) Ph(2-F,4-OCHF₂,5-Br) Ph(2-F,4-CF₂CF₂H,5-CN) Ph(2-F,4-OMe,5-CF₂CF₂H) Ph(2-F,4-OCHF₂,5-I) Ph(2-F,4-CF₂H,5-Cl) Ph(2-F,4-OMe,5-CF₂H) Ph(2-F,4-OCHF₂,5-Me) Ph(2-F,4-CF₂H,5-F) Ph(2-F,4,5-di-OMe) Ph(2-F,4-OCHF₂,5-Ei) Ph(2-F,4-CF₂H,5-Br) Ph(2-F,4-OMe,5-OCF₃) Ph(2-F,4-OCHF₂,5-n-Pr) Ph(2-F,4-CF₂H,5-I) Ph(2-F,4-OMe,5-OCHF₂) Ph(2-F,4-OCHF₂,5-t-Bu) Ph(2-F,4-CF₂H,5-Me) Ph(2-F,4-OMe,5-OCF₂CF₂H) Ph(2-F,4-OCHF₂,5-i-Pr) Ph(2-F,4-CF₂H,5-Ei) Ph(2-F,4-OMe,5-OCF₂CF₃) Ph(2-F,4-OCHF₂,5-c-Pr) Ph(2-F,4-CF₂H,5-n-Pr) Ph(2-F,4-OMe,5-SO₂Me) Ph(2-F,4-OCHF₂CF₃,5-CF₃) Ph(2-F,4-CF₂H,5-t-Bu) Ph(2-F,4-OMe,5-TMS) Ph(2-F,4-OCF₂CF₃,5-CF₂CF₃) Ph(2-F,4-CF₂H,5-i-Pr) Ph(2-F,4-OMe,5-CN) Ph(2-F,4-OCHF₂,5-CF₂CF₂H) Ph(2-F,4-CF₂H,5-c-Pr) Ph(2-F,4-OCF₃,5-Cl) Ph(2-F,4-OCHF₂,5-CF₂H) Ph(2-F,4-CF₂H,5-CF₃) Ph(2-F,4-OCF₃,5-F) Ph(2-F,4-OCHF₂,5-OMe) Ph(2-F,4-CF₂H,5-CF₂CF₃) Ph(2-F,4-OCF₃,5-Br) Ph(2-F,4-OCHF₂,5-OCF₃) Ph(2-F,4-CF₂H,5-CF₂CF₂H) Ph(2-F,4-OCF₃,5-I) Ph(2-F,4,5-di-OCHF₂) Ph(2-F,4,5-di-CF₂H) Ph(2-F,4-OCF₃,5-Me) Ph(2-F,4-OCHF₂,5-OCF₂CF₂H) Ph(2-F,4-CF₂H,5-OMe) Ph(2-F,4-OCF₃,5-Ei) Ph(2-F,4-OCHF₂,5-OCF₂CF₃) Ph(2-F,4-CF₂H,5-OCF₃) Ph(2-F,4-OCF₃,5-n-Pr) Ph(2-F,4-OCHF₂,5-SO₂Me) Ph(2-F,4-CF₂H,5-OCHF₂) Ph(2-F,4-OCF₃,5-t-Bu) Ph(2-F,4-OCHF₂,5-TMS) Ph(2-F,4-CF₂H,5-OCF₂CF₂H) Ph(2-F,4-OCF₃,5-i-Pr) Ph(2-F,4-OCHF₂,5-CN) Ph(2-F,4-CF₂H,5-OCF₂CF₃) Ph(2-F,4-OCF₃,5-c-Pr) Ph(2-F,4-OCF₂CF₂H,5-Cl) Ph(2-F,4-CF₂H,5-SO₂Me) Ph(2-F,4-OCF₃,5-CF₃) Ph(2-F,4-OCF₂CF₂H,5-F) Ph(2-F,4-CF₂H,5-TMS) Ph(2-F,4-OCF₃,5-CF₂CF₃) Ph(2-F,4-OCF₂CF₂H,5-Br) Ph(2-F,4-OCF₂CF₂H,5-I) Ph(2-F,4-OCF₂CF₃,5-OCHF₂) Ph(2-F,4-TMS,5-t-Bu) Ph(2-F,4-OCF₂CF₂H,5-Me) Ph(2-F,4-OCF₂CF₃,5-OCF₂CFH) Ph(2-F,4-TMS,5-i-Pr) Ph(2-F,4-OCF₂CF₂H,5-Ei) Ph(2-F,4,5-di-OCF₂CF₃) Ph(2-F,4-TMS,5-c-Pr) Ph(2-F,4-OCF₂CF₂H,5-n-Pr) Ph(2-F,4-OCF₂CF₃,5-SO₂Me) Ph(2-F,4-TMS,5-CF₃) Ph(2-F,4-OCF₂CF₂H,5-t-Bu) Ph(2-F,4-OCF₂CF₃,5-TMS) Ph(2-F,4- TMS,5-CF₂CF₃) Ph(2-F,4-OCF₂CF₂H,5-i-Pr) Ph(2-F,4-OCF₂CF₃,5-CN) Ph(2-F,4-TMS,5-CF₂CF₂H) Ph(2-F,4-OCF₂CF₂H,5-c-Pr) Ph(2-F,4-SO₂Me,5-C1) Ph(2-F,4-TMS,5-CF₂H) Ph(2-F,4-OCF₂CF₂HCF₃,5-CF₃) Ph(2-F,4-SO₂Me,5-F) Ph(2-F,4-TMS,5-OMe) Ph(2-F,4-OCF₂CF₂H,5-CFCF₃) Ph(2-F,4-SO₂Me,5-Br) Ph(2-F,4-TMS,5-OCF₃) Ph(2-F,4-OCF₂CF₂H,5-CF₂CF₂H Ph(2-F,4-SO₂Me,5-I) Ph(2-F,4-TMS,5-OCHF₂) Ph(2-F,4-OCF₂CF₂H,5-CF₂H) Ph(2-F,4-SO₂Me,5-Me) Ph(2-F,4-TMS,5-OCF₂CF₂H) Ph(2-F,4-OCF₂CF₂H,5-OMe) Ph(2-F,4-SO₂Me,5-Ei) Ph(2-F,4-TMS,5-OCF₂CF₃) Ph(2-F,4-OCF₂CF₂H,5-OCF₃) Ph(2-F,4-SO₂Me,5-n-Pr) Ph(2-F,4-TMS,5-SO₂Me) Ph(2-F,4-OCF₂CF₂H,5-OCHF₂) Ph(2-F,4-SO₂Me,5-t-Bu) Ph(2-F,4,5-di-TMS) Ph(2-F,4,5-di-OCFCF₂H) Ph(2-F,4-SO₂Me,5-i-Pr) Ph(2-F,4-TMS,5-CN) Ph(2-F,4-OCF₂CF₂H,5-OCF₂CF₃) Ph(2-F,4-SO₂Me,5-c-Pr) Ph(2-F,4-CN,5-Cl) Ph(2-F,4-OCF₂CF₂H,5-SO₂Me) Ph(2-F,4SO₂MeCF₃,5-CF₃) Ph(2-F,4-CN,5-F) Ph(2-F,4-OCF₂CF₂H,5-TMS) Ph(2-F,4-SO₂Me,5-CF₂CF₃) Ph(2-F,4-CN,5-Br) Ph(2-F,4-OCF₂CF₂,5-CN) Ph(2-F,4-SO₂Me,5-CF₂CF₂H) Ph(2-F,4-CN,5-I) Ph(2-F,4-OCF₂CF₃,5-Cl) Ph(2-F,4-SO₂Me,5-CF₂H) Ph(2-F,4-CN,5-Me) Ph(2-F,4-OCF₂CF₃,5-F) Ph(2-F,4-SO₂Me,5-OMe) Ph(2-F,4-CN,5-Ei) Ph(2-F,4-OCF₂CF₃,5-Br) Ph(2-F,4-SO₂Me,5-OCF₃) Ph(2-F,4-CN,5-n-Pr) Ph(2-F,4-OCF₂CF₃,5-I) Ph(2-F,4-SO₂Me,5-OCHF₂) Ph(2-F,4-CN,5-t-Bu) Ph(2-F,4-OCF₂CF₃,5-Me) Ph(2-F,4-SO₂Me,5-OCF₂CF₂H) Ph(2-F,4-CN,5-i-Pr) Ph(2-F,4-OCF₂CF₃,5-Ei) Ph(2-F,4-SO₂Me,5-OCF₂CF₃) Ph(2-F,4-CN,5-c-Pr) Ph(2-F,4-OCF₂CF₃,5-n-Pr) Ph(2-F,4,5-di-SO₂Me) Ph(2-F,4-CN,5-CF₃) Ph(2-F,4-OCF₂CF₃,5-t-Bu) Ph(2-F,4-SO₂Me,5-TMS) Ph(2-F,4-CN,5-CF₂CF₃) Ph(2-F,4-OCF₂CF₃,5-i-Pr) Ph(2-F,4-SO₂Me,5-CN) Ph(2-F,4-CN,5-CF₂CF₂H) Ph(2-F,4-OCF₂CF,5-c-Pr) Ph(2-F,4-TMS,5-C1) Ph(2-F,4-CN,5-CF₂H) Ph(2-F,4-OCF₂CF₃CF₃,5-CF₃) Ph(2-F,4-TMS,5-F) Ph(2-F,4-CN,5-OMe) Ph(2-F,4-OCF₂CF₃,5-CF₂CF₃) Ph(2-F,4-TMS,5-Br) Ph(2-F,4-CN,5-OCF₃) Ph(2-F,4-OCF₂CF₃,5-CF₂CF₂H) Ph(2-F,4-TMS,5-I) Ph(2-F,4-CN,5-OCHF₂) Ph(2-F,4-OCF₂CF₃,5-CF₂H) Ph(2-F,4-TMS,5-Me) Ph(2-F,4-CN,5-OCF₂CF₂H) Ph(2-F,4-OCF₂CF₃,5-OMe) Ph(2-F,4-TMS,5-Ei) Ph(2-F,4-CN,5-OCF₂CF₃) Ph(2-F,4-OCF₂CF₃,5-OCF₃) Ph(2-F,4-TMS,5-n-Pr) Ph(2-F,4-CN,5-SO₂Me) Ph(2-F,4-CN,5-TMS) Ph(3-F,4-CF₂CF₃,5-F) Ph(3-Me,4-Br,5-Me) Ph(2-F,4,5-di-CN) Ph(3-F,4-CF₂CF₂H,5-F) Ph(3-Me,4-I,5-Me) Ph(3,4,5-tri-Cl) Ph(3-F,4-CF₂H,5-F) Ph(3,4-tri-Me) Ph(3-Cl,4-F,5-Cl) Ph(3-F,4-OMe,5-F) Ph(3-Me,4-Et,5-Me) Ph(3-Cl,4-Br,5-Cl) Ph(3-F,4-OCF₃,5-F) Ph(3-Me,4-n-Pr,5-Me) Ph(3-Cl,4-I,5-Cl) Ph(3-F,4-OCHF₂,5-F) Ph(3-Me,4-t-Bu,5-Me) Ph(3-Cl,4-Me,5-Cl) Ph(3-F,4-OCF₂CF₂H,5-F) Ph(3-Me,4-i-Pr,5-Me) Ph(3-Cl,4-Et,5-Cl) Ph(3-F,4-OCF₂CF₃,5-F) Ph(3-Me,4-c-Pr,5-Me) Ph(3-Cl,4-n-Pr,5-Cl) Ph(3-F,4-SO₂Me,5-F) Ph(3-Me,4-CF₃,5-Me) Ph(3-Cl,4-t-Bu,5-Cl) Ph(3-F,4-TMS,5-F) Ph(3-Me,4-CF₂CF₃,5-Me) Ph(3-Cl,4-i-Pr,5-Cl) Ph(3-F,4-CN,5-F) Ph(3-Me,4-CF₂CF₂H,5-Me) Ph(3-Cl,4-c-Pr,5-Cl) Ph(3-Br,4-Cl,5-Br) Ph(3-Me,4-CF₂H,5-Me) Ph(3-Cl,4-CF₃,5-Cl) Ph(3-Br,4-F,5-Br) Ph(3-Me,4-OMe,5-Me) Ph(3-Cl,4-CF₂CF₃,5-Cl) Ph(3,4,5-tri-Br) Ph(3-Me,4-OCF₃,5-Me) Ph(3-Cl,4-CF₂CF₂H,5-Cl) Ph(3-Br,4-I,5-Br) Ph(3-Me,4-OCHF₂,5-Me) Ph(3-Cl,4-CF₂H,5-Cl) Ph(3-Br,4-Me,5-Br) Ph(3-Me,4-OCF₂CF₂H,5-Me) Ph(3-Cl,4-OMe,5-Cl) Ph(3-Br,4-Et,5-Br) Ph(3-Me,4-OCF₂CF₃,5-Me) Ph(3-Cl,4-OCF₃,5-Cl) Ph(3-Br,4-n-Pr,5-Br) Ph(3-Me,4-SO₂Me,5-Me) Ph(3-Cl,4-OCHF₂,5-Cl) Ph(3-Br,4-t-Bu,5-Br) Ph(3-Me,4-TMS,5-Me) Ph(3-Cl,4-OCF₂CF₂H,5-Cl) Ph(3-Br,4-i-Pr,5-Br) Ph(3-Me,4-CN,5-Me) Ph(3-Cl,4-OCF₂CF₃,5-Cl) Ph(3-Br,4-c-Pr,5-Br) Ph(3-CF₃,4-C1,5-CF₃) Ph(3-Cl,4-SO₂Me,5-Cl) Ph(3-Br,4-CF₃,5-Br) Ph(3-CF₃,4-F,5-CF₃) Ph(3-Cl,4-TMS,5-Cl) Ph(3-Br,4-CF₂CF₃,5-Br) Ph(3-CF₃,4-Br,5-CF₃) Ph(3-Cl,4-CN,5-Cl) Ph(3-Br,4-CF₂CF₂H,5-Br) Ph(3-CF₃,4-I,5-CF₃) Ph(3-F,4-Cl,5-F) Ph(3-Br,4-CF₂H,5-Br) Ph(3-CF₃,4-Me,5-CF₃) Ph(3,4,5-tri-F) Ph(3-Br,4-OMe,5-Br) Ph(3-CF₃,4-Ei,5-CF₃) Ph(3-F,4-Br,5-F) Ph(3-Br,4-OCF₃,5-Br) Ph(3-CF₃,4-n-Pr,5-CF₃) Ph(3-F,4-I,5-F) Ph(3-Br,4-OCHF₂,5-Br) Ph(3-CF₃,4-t-Bu,5-CF₃) Ph(3-F,4-Me,5-F) Ph(3-Br,4-OCF₂CF₂H,5-Br) Ph(3-CF₃,4-i-Pr,5-CF₃) Ph(3-F,4-Et,5-F) Ph(3-Br,4-OCF₂CF₃,5-Br) Ph(3-CF₃,4-c-Pr,5-CF₃) Ph(3-F,4-n-Pr,5-F) Ph(3-Br,4-SO₂Me,5-Br) Ph(3,4,5-tri-CF₃) Ph(3-F,4-t-Bu,5-F) Ph(3-Br,4-TMS,5-Br) Ph(3-CF₃,4-CF₂CF₃,5-CF₃) Ph(3-F,4-i-Pr,5-F) Ph(3-Br,4-CN,5-Br) Ph(3-CF₃,4-CF₂CF₂H,5-CF₃) Ph(3-F,4-c-Pr,5-F) Ph(3-Me,4-Cl,5-Me) Ph(3-CF₃,4-CF₂H,5-CF₃) Ph(3-F,4-CF₃,5-F) Ph(3-Me,4-F,5-Me) Ph(3-CF₃,4-OMe,5-CF₃) Ph(3-CF₃,4-OCF₃,5-CF₃) Ph(2-Cl,3-Cl,4-n-Pr,5-Cl) Ph(2-Cl,3-F,4-SO₂Me,5-F) Ph(3-CF₃,4-OCHF₂,5-CF₃) Ph(2-Cl,3-Cl,4-t-Bu,5-Cl) Ph(2-Cl,3-F,4-TMS,5-F) Ph(3-CF₃,4-OCF₂CF₂H,5-CF₃) Ph(2-Cl,3-Cl,4-i-Pr,5-Cl) Ph(2-Cl,3-F,4-CN,5-F) Ph(3-CF₃,4-OCF₂CF₃,5-CF₃) Ph(2-Cl,3-Cl,4-c-Pr,5-Cl) Ph(2-Cl,3-Br,4-Cl,5-Br) Ph(3-CF₃,4-SO₂Me,5-CF₃) Ph(2-Cl,3-Cl,4-CF₃,5-Cl) Ph(2-Cl,3-Br,4-F,5-Br) Ph(3-CF₃,4-IMS,5-CF₃) Ph(2-Cl,3-Cl,4-CF₂CF₃,5-Cl) Ph(2-Cl,3,4,5-tri-Br) Ph(3-CF₃,4-CN,5-CF₃) Ph(2-Cl,3-Cl,4-CF₂CF₂H,5-Cl) Ph(2-Cl,3-Br,4-I,5-Br) Ph(3-OCHF₂,4-Cl,5-OCHF₂) Ph(2-Cl,3-Cl,4-CF₂H,5-Cl) Ph(2-Cl,3-Br,4-Me,5-Br) Ph(3-OCHF₂,4-F,5-OCHF₂) Ph(2-Cl,3-Cl,4-OMe,5-Cl) Ph(2-Cl,3-Br,4-Et,5-Br) Ph(3-OCHF₂,4-Br,5-OCHF₂) Ph(2-Cl,3-Cl,4-OCF₃,5-Cl) Ph(2-Cl,3-Br,4-n-Pr,5-Br) Ph(3-OCHF₂,4-I,5-OCHF₂) Ph(2-Cl,3-Cl,4-OCHF₂,5-Cl) Ph(2-Cl,3-Br,4-t-Bu,5-Br) Ph(3-OCHF₂,4-Me,5-OCHF₂) Ph(2-Cl,3-Cl,4-OCF₂CF₂H,5-Cl) Ph(2-Cl,3-Br,4-i-Pr,5-Br) Ph(3-OCHF₂,4-Ei,5-OCHF₂) Ph(2-Cl,3-Cl,4-OCF₂CF₃,5-Cl) Ph(2-Cl,3-Br,4-c-Pr,5-Br) Ph(3-OCHF₂,4-n-Pr,5-OCHF₂) Ph(2-Cl,3-Cl,4-SO₂Me,5-Cl) Ph(2-Cl,3-Br,4-CF₃,5-Br) Ph(3-OCHF₂,4-t-Bu,5-OCHF₂) Ph(2-Cl,3-Cl,4-TMS,5-Cl) Ph(2-Cl,3-Br,4-CF₂CF₃,5-Br) Ph(3-OCHF₂,4-i-Pr,5-OCHF₂) Ph(2-Cl,3-Cl,4-CN,5-Cl) Ph(2-Cl,3-Br,4-CF₂CF₂H,5-Br) Ph(3-OCHF₂,4-c-Pr,5-OCHF₂) Ph(2-Cl,3-F,4-Cl,5-F) Ph(2-Cl,3-Br,4-CF₂H,5-Br) Ph(3-OCHF₂CF₃,4-CF₃,5-OCHF₂) Ph(2-Cl,3,4,5-tri-F) Ph(2-Cl,3-Br,4-OMe,5-Br) Ph(3-OCF₂CF₃,4-CF₂CF₃,5-OCHF₂) Ph(2-Cl,3-F,4-Br,5-F) Ph(2-Cl,3-Br,4-OCF₃,5-Br) Ph(3-OCHF₂,4-CF₂CF₂H,5-OCHF₂) Ph(2-Cl,3-F,4-I,5-F) Ph(2-Cl,3-Br,4-OCHF₂,5-Br) Ph(3-OCHF₂,4-CF₂H,5-OCHF₂) Ph(2-Cl,3-F,4-Me,5-F) Ph(2-Cl,3-Br,4-OCF₂CF₂H,5-Br) Ph(3-OCHF₂,4-OMe,5-OCHF₂) Ph(2-Cl,3-F,4-Et,5-F) Ph(2-Cl,3-Br,4-OCF₂CF₃,5-Br) Ph(3-OCHF₂,4-OCF₂,5-OCHF₂) Ph(2-Cl,3-F,4-n-Pr,5-F) Ph(2-C1,3-Br,4-SO₂SO₂Me,5-Br) Ph(3,4,5-tri-OCHF₂) Ph(2-C1,3-F,4-t-Bu,5-F) Ph(2-Cl,3-Br,4-TMS,5-Br) Ph(3-OCHF₂,4-OCF₂CF₂H,5-OCHF₂) Ph(2-Cl,3-F,4-i-Pr,5-F) Ph(2-Cl,3-Br,4-CN,5-Br) Ph(3-OCHF₂,4-OCF₂CF₃,5-OCHF₂) Ph(2-Cl,3-F,4-c-Pr,5-F) Ph(2-Cl,3-Me,4-Cl,5-Me) Ph(3-OCHF₂,4-SO₂Me,5-OCHF₂) Ph(2-Cl,3-F,4-CF₃,5-F) Ph(2-Cl,3-Me,4-F,5-Me) Ph(3-OCHF₂,4-TMS,5-OCHF₂) Ph(2-Cl,3-F,4-CF₂CF₃,5-F) Ph(2-Cl,3-Me,4-Br,5-Me) Ph(3-OCHF₂,4-CN,5-OCHF₂) Ph(2-Cl,3-F,4-CF₂CF₂H,5-F) Ph(2-Cl,3-Me,4-I,5-Me) Ph(2,3,4,5-tetra-Cl) Ph(2-Cl,3-F,4-CF₂H,5-F) Ph(2-Cl,3,4-tri-Me) Ph(2-Cl,3-Cl,4-F,5-Cl) Ph(2-Cl,3-F,4-OMe,5-F) Ph(2-Cl,3-Me,4-Et,5-Me) Ph(2-Cl,3-Cl,4-Br,5-Cl) Ph(2-Cl,3-F,4-OCF₃,5-F) Ph(2-Cl,3-Me,4-n-Pr,5-Me) Ph(2-Cl,3-Cl,4-I,5-Cl) Ph(2-Cl,3-F,4-OCHF₂,5-F) Ph(2-Cl,3-Me,4-t-Bu,5-Me) Ph(2-Cl,3-Cl,4-Me,5-Cl) Ph(2-Cl,3-F,4-OCF₂CF₂H,5-F) Ph(2-Cl,3-Me,4-i-Pr,5-Me) Ph(2-Cl,3-Cl,4-Et,5-Cl) Ph(2-Cl,3-F,4-OCF₂CF₃,5-F) Ph(2-Cl,3-Me,4-c-Pr,5-Me) Ph(2-Cl,3-Me,4-CF₂,5-Me) Ph(2-Cl,3-Me,4-CF₂H,5-Me) Ph(2-Cl,3-Me,4-OCHF₂,5-Me) Ph(2-Cl,3-Me,4-CF₂CF₂,5-Me) Ph(2-Cl,3-Me,4-OMe,5-Me) Ph(2-Cl,3-Me,4-OCF₂CF₂H,5-Me) Ph(2-Cl,3-Me,4-CF₂CF₂H,5-Me) Ph(2-Cl,3-Me,4-OCF₂,5-Me) Q¹ Q¹ Ph(2-Cl,3-Me,4-OCF₂CF₃,5-Me) Ph(2-Cl,3-OCHF₂CF₃,4-CF₃,5-OCHF₂) Ph(2-Cl,3-Me,4-SO₂Me,5-Me) Ph(2-Cl,3-OCF₂CF₃,4-CF₂CF₃,5-OCHF₂) Ph(2-Cl,3-Me,4-TMS,5-Me) Ph(2-Cl,3-OCHF₂,4-CF₂CF₂,5-OCHF₂) Ph(2-Cl,3-Me,4-CN,5-Me) Ph(2-Cl,3-OCHF₂,4-CF₂H,5-OCHF₂) Ph(2-Cl,3-CF₃,4-Cl,5-CF₃) Ph(2-Cl,3-OCHF₂,4-OMe,5-OCHF₂) Ph(2-C1,3-CF₃,4-F,5-CF₃) Ph(2-Cl,3-OCHF₂,4-OCF₃,5-OCHF₂) Ph(2-C1,3-CF₃,4-Br,5-CF₃) Ph(2-Cl,3,4,5-tri-OCHF₂) Ph(2-C1,3-CF₃,4-I,5-CF₃) Ph(2-Cl,3-OCHF₂,4-OCF₂CF₂H,5-OCH₂) Ph(2-Cl,3-CF₃,4-Me,5-CF₃) Ph(2-Cl,3-OCHF₂,4-OCF₂CF₃,5-OCHF₂) Ph(2-Cl,3-CF₃,4-Ei,5-CF₃) Ph(2-Cl,3-OCHF₂,4-SO₂Me,5-OCHF₂) Ph(2-Cl,3-CF₃,4-n-Pr,5-CF₃) Ph(2-Cl,3-OCHF₂,4-TMS,5-OCHF₂) Ph(2-Cl,3-CF₃,4-t-Bu,5-CF₃) Ph(2-Cl,3-OCHF₂,4-CN,5-OCHF₂) Ph(2-Cl,3-CF₃,4-i-Pr,5-CF₃) Ph(2-F,3,4,5-tri-Cl) Ph(2-Cl,3-CF₃,4-c-Pr,5-CF₃) Ph(2-F,3-Cl,4-F,5-Cl) Ph(2-Cl,3,4,5-tri-CF₃) Ph(2-F,3-Cl,4-Br,5-Cl) Ph(2-Cl,3-CF₃,4-CF₂CF₃,5-CF₃) Ph(2-F,3-Cl,4-I,5-Cl) Ph(2-Cl,3-CF₃,4-CF₂CF₂H,5-CF₃) Ph(2-F,3-Cl,4-Me,5-Cl) Ph(2-Cl,3-CF₃,4-CF₂H,5-CF₃) Ph(2-F,3-Cl,4-Et,5-Cl) Ph(2-Cl,3-CF₃,4-OMe,5-CF₃) Ph(2-F,3-Cl,4-n-Pr,5-Cl) Ph(2-Cl,3-CF₃,4-OCF₃,5-CF₃) Ph(2-F,3-Cl,4-t-Bu,5-Cl) Ph(2-Cl,3-CF₃,4-OCHF₂,5-CF₃) Ph(2-F,3-Cl,4-i-Pr,5-Cl) Ph(2-Cl,3-CF₃,4-OCF₂CF₂H,5-CF₃) Ph(2-F,3-Cl,4-c-Pr,5-Cl) Ph(2-Cl,3-CF₃,4-OCF₂CF₃,5-CF₃) Ph(2-F,3-Cl,4-CF₃,5-Cl) Ph(2-Cl,3-CF₃,4-SO₂Me,5-CF₃) Ph(2-F,3-Cl,4-CF₂CF₃,5-Cl) Ph(2-Cl,3-CF₃,4-IMS,5-CF₃) Ph(2-F,3-Cl,4-CF₂CF₂H,5-Cl) Ph(2-Cl,3-CF₃,4-CN,5-CF₃) Ph(2-F,3-Cl,4-CF₂H,5-Cl) Ph(2-Cl,3-OCHF₂,4-Cl,5-OCHF₂) Ph(2-F,3-Cl,4-OMe,5-Cl) Ph(2-Cl,3-OCHF₂,4-F,5-OCHF₂) Ph(2-F,3-Cl,4-OCF₃,5-Cl) Ph(2-Cl,3-OCHF₂,4-Br,5-OCHF₂) Ph(2-F,3-Cl,4-OCHF₂,5-Cl) Ph(2-Cl,3-OCHF₂,4-I,5-OCHF₂) Ph(2-F,3-Cl,4-OCF₂CF₂H,5-Cl) Ph(2-Cl,3-OCHF₂,4-Me,5-OCHF₂) Ph(2-F,3-Cl,4-OCF₂CF₃,5-Cl) Ph(2-Cl,3-OCHF₂,4-Ei,5-OCHF₂) Ph(2-F,3-Cl,4-SO₂Me,5-Cl) Ph(2-Cl,3-OCHF₂,4-n-Pr,5-OCHF₂) Ph(2-F,3-Cl,4-TMS,5-Cl) Ph(2-Cl,3-OCHF₂,4-t-Bu,5-OCHF₂) Ph(2-F,3-Cl,4-CN,5-Cl) Ph(2-Cl,3-OCHF₂,4-i-Pr,5-OCHF₂) Ph(2-F,3-F,4-Cl,5-F) Ph(2-Cl,3-OCHF₂,4-c-Pr,5-OCHF₂) Ph(2,3,4,5-tetra-F) Ph(2-F,3-F,4-Br,5-F) Ph(2-F,3-Br,4-TMS,5-Br) Ph(2-F,3-F,4-I,5-F) Ph(2-F,3-Br,4-CN,5-Br) Ph(2-F,3-F,4-Me,5-F) Ph(2-F,3-Me,4-Cl,5-Me) Ph(2-F,3-F,4-Et,5-F) Ph(2-F,3-Me,4-F,5-Me) Ph(2-F,3-F,4-n-Pr,5-F) Ph(2-F,3-Me,4-Br,5-Me) Ph(2-F,3-F,4-t-Bu,5-F) Ph(2-F,3-Me,4-I,5-Me) Ph(2-F,3-F,4-i-Pr,5-F) Ph(2-F,3,4-tri-Me) Ph(2-F,3-F,4-c-Pr,5-F) Ph(2-F,3-Me,4-Et,5-Me) Ph(2-F,3-F,4-CF₃,5-F) Ph(2-F,3-Me,4-n-Pr,5-Me) Ph(2-F,3-F,4-CF₂CF₃,5-F) Ph(2-F,3-Me,4-t-Bu,5-Me) Ph(2-F,3-F,4-CF₂CF₂H,5-F) Ph(2-F,3-Me,4-i-Pr,5-Me) Ph(2-F,3-F,4-CF₂H,5-F) Ph(2-F,3-Me,4-c-Pr,5-Me) Ph(2-F,3-F,4-OMe,5-F) Ph(2-F,3-Me,4-CF₃,5-Me) Ph(2-F,3-F,4-OCF₂,5-F) Ph(2-F,3-Me,4-CF₂CF₃,5-Me) Ph(2-F,3-F,4-OCHF₂,5-F) Ph(2-F,3-Me,4-CF₂CF₂H,5-Me) Ph(2-F,3-F,4-OCF₂CF₂H,5-F) Ph(2-F,3-Me,4-CF₂H,5-Me) Ph(2-F,3-F,4-OCF₂CF₃,5-F) Ph(2-F,3-Me,4-OMe,5-Me) Ph(2-F,3-F,4-SO₂Me,5-F) Ph(2-F,3-Me,4-OCF₃,5-Me) Ph(2-F,3-F,4-TMS,5-F) Ph(2-F,3-Me,4-OCHF₂,5-Me) Ph(2-F,3-F,4-CN,5-F) Ph(2-F,3-Me,4-OCF₂CF₂H,5-Me) Ph(2-F,3-Br,4-Cl,5-Br) Ph(2-F,3-Me,4-OCF₂CF₃,5-Me) Ph(2-F,3-Br,4-F,5-Br) Ph(2-F,3-Me,4-SO₂Me,5-Me) Ph(2-F,3,4,5-tri-Br) Ph(2-F,3-Me,4-TMS,5-Me) Ph(2-F,3-Br,4-I,5-Br) Ph(2-F,3-Me,4-CN,5-Me) Ph(2-F,3-Br,4-Me,5-Br) Ph(2-F,3-CF₃,4-Cl,5-CF₃) Ph(2-F,3-Br,4-Et,5-Br) Ph(2-F,3-CF₃,4-F,5-CF₃) Ph(2-F,3-Br,4-n-Pr,5-Br) Ph(2-F,3-CF₃,4-Br,5-CF₃) Ph(2-F,3-Br,4-t-Bu,5-Br) Ph(2-F,3-CF₃,4-I,5-CF₃) Ph(2-F,3-Br,4-i-Pr,5-Br) Ph(2-F,3-CF₃,4-Me,5-CF₃) Ph(2-F,3-Br,4-c-Pr,5-Br) Ph(2-F,3-CF₃,4-Ei,5-CF₃) Ph(2-F,3-Br,4-CF₃,5-Br) Ph(2-F,3-CF₃,4-n-Pr,5-CF₃) Ph(2-F,3-Br,4-CF₂CF₃,5-Br) Ph(2-F,3-CF₃,4-t-Bu,5-CF₃) Ph(2-F,3-Br,4-CF₂CF₂H,5-Br) Ph(2-F,3-CF₃,4-i-Pr,5-CF₃) Ph(2-F,3-Br,4-CF₂H,5-Br) Ph(2-F,3-CF₃,4-c-Pr,5-CF₃) Ph(2-F,3-Br,4-OMe,5-Br) Ph(2-F,3,4,5-tri-CF₃) Ph(2-F,3-Br,4-OCF₃,5-Br) Ph(2-F,3-CF₃,4-CF₂CF₃,5-CF₃) Ph(2-F,3-Br,4-OCHF₂,5-Br) Ph(2-F,3-CF₃,4-CF₂CF₂H,5-CF₃) Ph(2-F,3-Br,4-OCF₂CF₂H,5-Br) Ph(2-F,3-CF₃,4-CF₂H,5-CF₃) Ph(2-F,3-Br,4-OCF₂CF₃,5-Br) Ph(2-F,3-CF₃,4-OMe,5-CF₃) Ph(2-F,3-Br,4-SO₂Me,5-Br) Ph(2-F,3-CF₃,4-OCF₃,5-CF₃) Ph(2-F,3-CF₃,4-OCHF₂,5-CF₃) Ph(2-F,3-OCHF₂,4-OCF₂CF₃,5-OCHF₂) Ph(2-F,3-CF,4-OCF₂CF₂H,5-CF₃) Ph(2-F,3-OCHF₂,4-SO₂Me,5-OCHF₂) Ph(2-F,3-CF₃,4-OCF₂CF₃,5-CF₃) Ph(2-F,3-OCHF₂,4-TMS,5-OCHF₂) Ph(2-F,3-CF₃,4-SO₂Me,5-CF₃) Ph(2-F,3-OCHF₂,4-CN,5-OCHF₂) Ph(2-F,3-CF₃,4-IMS,5-CF₃) 1H-Imidazol-2-yl(1-CF₂CF₂H,5-Cl) Ph(2-F,3-CF₃,4-CN,5-CF₃) 1H-Imidazol-2-yl(1-CF₂CF₂H,5-F) Ph(2-F,3-OCHF₂,4-Cl,5-OCHF₂) 1H-Imidazo1-2-yl(1-CH₂CF₃,5-Cl) Ph(2-F,3-OCHF₂,4-F,5-OCHF₂) 1H-Imidazo1-2-yl(1-CH₂CF₃,5-F) Ph(2-F,3-OCHF₂,4-Br,5-OCHF₂) 1H-Imidazol-2-yl(1-Me,5-CF₂H) Ph(2-F,3-OCHF₂,4-I,5-OCHF₂) 1H-Imidazol-2-yl(1-CF₂CF₂H,5-CF₂H) Ph(2-F,3-OCHF₂,4-Me,5-OCHF₂) 1H-Imidazol-2-yl(1-CH₂CF₃,5-CF₂H) Ph(2-F,3-OCHF₂,4-Ei,5-OCHF₂) 1H-Imidazol-2-yl(1-Me,5-CF₃) Ph(2-F,3-OCHF₂,4-n-Pr,5-OCHF₂) 1H-Imidazol-2-yl(1-CF₂CF₂H,5-CF₃) Ph(2-F,3-OCHF₂,4-t-Bu,5-OCHF₂) 1H-Imidazo1-2-yl(1-CF₂CF₃,5-CF₃) Ph(2-F,3-OCHF₂,4-i-Pr,5-OCHF₂) 1,3-Benzodioxol-4-yl Ph(2-F,3-OCHF₂,4-c-Pr,5-OCHF₂) 1,3-Benzodioxol-4-yl(2,2-di-Me) Ph(2-F,3-OCH₂,4-CF₃,5-OCHF₂) 1,3-Benzodioxol-4-yl(2,2-di-F) Ph(2-F,3-OCHF₂CF₃,4-CF₂CF₃,5-OCHF₂) 1,4-Benzodioxol-4-yl(2,3-dihydro) Ph(2-F,3-OCHF₂,4-CF₂CF₂CF₂H,5-OCHF₂) 1,4-Benzodioxol-4-yl(2,2,3,3-tetrafluoro) Ph(2-F,3-OCHF₂,4-CF₂H,5-OCHF₂) 1H-Pyrazol-3-yl(1-CH₂CF₃,4-F) Ph(2-F,3-OCHF₂,4-OMe,5-OCHF₂) 1H-Pyrazol-3-yl(1-CH₂CF₃,4-Cl) Ph(2-F,3-OCHF₂,4-OCF₃,5-OCHF₂) 1H-Pyrazol-3-yl(1-CF₂CF₂H,4-F) Ph(2-F,3,4,5-tri-OCHF₂) 1H-Pyrazol-3-yl(1-CF₂CF₂H,4-Cl) Ph(2-F,3-OCHF₂,4-OCF₂CF₂H,5-OCHF₂) Table 2 is constructed in the same manner except that the Row Heading “R is Me; Q² is Ph(2-F) and Q¹ is” is replaced with the Row Heading listed for Table 2 below (i.e. “R is Me; Q² is Ph(2,3-diF) and Q¹ is”). Therefore the first entry in Table 2 is a compound of Formula I wherein R is Me; Q² is Ph(2,3-diF) and Q¹ is Ph(2-C1) (i.e. 2-chlorophenyl). Tables 3 through 688 are constructed similarly.

Table Row Heading 2 R is Me; Q² is Ph(2,3-diF); and Q¹ is 3 R is Me; Q² is Ph(2,4-diF); and Q¹ is 4 R is Me; Q² is Ph(2,5-di-F); and ν is 5 R is Me; Q² is Ph(2,3,4-tri-F); and Q¹ is 6 R is Me; Q² is Ph(2,3,5-tri-F); and Q¹ is 7 R is Me; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 8 R is Me; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 9 R is Me; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 10 R is Me; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 11 R is Me; Q² is Ph(2-F,3-Me); and Q¹ is 12 R is Me; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 13 R is Me; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 14 R is Me; Q² is Ph(2-F,3-Cl); and Q¹ is 15 R is Me; Q² is Ph(2-F,4-Cl); and Q¹ is 16 R is Me; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 17 R is Me; Q² is Ph(2-F,4-Br); and Q¹ is 18 R is Me; Q² is Ph(2-F,3-OMe); and Q¹ is 19 R is Me; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 20 R is Me; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 21 R is Me; Q² is Ph(2-F,3-CF₂H); and Q¹ is 22 R is Me; Q² is Ph(2-F,3-CF₃); and Q¹ is 23 R is Me; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 24 R is Me; Q² is Ph(2-F,3-NO₂); and Q¹ is 25 R is Me; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 26 R is Me; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 27 R is Me; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 28 R is Me; Q² is Ph(2-CF₃); and Q¹ is 29 R is Me; Q² is Ph(2-CF₃,3-F); and Q¹ is 30 R is Me; Q² is Ph(2-CF₃,3-Me); and Q¹ is 31 R is Me; Q² is Ph(2-CF₃,4-F); and Q¹ is 32 R is Me; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 33 R is Me; Q² is Ph(2-CF₃,4-F); and Q¹ is 34 R is Me; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 35 R is Me; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 36 R is Me; Q² is Ph(2-CF₂H); and Q¹ is 37 R is Me; Q² is Ph(2-CF₂H,3-F); and Q¹ is 38 R is Me; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 39 R is Me; Q² is Ph(2-CF₂H,4-F); and Q¹ is 40 R is Me; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 41 R is Me; Q² is Ph(2-CF₂H,4-F); and Q¹ is 42 R is Me; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 43 R is Me; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 44 R is Me; Q² is Ph(2-Me); and Q¹ is 45 R is Me; Q² is Ph(2,3-di-Me); and Q¹ is 46 R is Me; Q² is Ph(2-Me,3-F); and Q¹ is 47 R is Me; Q² is Ph(2-Me,3-Cl); and Q¹ is 48 R is Me; Q² is Ph(2-Me,3-CF₃); and Q¹ is 49 R is Me; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 50 R is Me; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 51 R is Me; Q² is Ph(2-Me,4-Cl); and Q¹ is 52 R is Me; Q² is Ph(2-Me,4-F); and Q¹ is 53 R is Me; Q² is Ph(2-Me,5-F); and Q¹ is 54 R is Me; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 55 R is Me; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 56 R is Me; Q² is Ph(2-Et); and Q¹ is 57 R is Me; Q² is Ph(2-Et,3-F); and Q¹ is 58 R is Me; Q² is Ph(2-Et,3-Cl); and Q¹ is 59 R is Me; Q² is Ph(2-Et,4-F); and Q¹ is 60 R is Me; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 61 R is Me; Q² is Ph(2-i-Pr); and Q¹ is 62 R is Me; Q² is Ph(2-i-Pr,3-F); and Q¹ is 63 R is Me; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 64 R is Me; Q² is Ph(2-i-Pr,4-F); and Q¹ is 65 R is Me; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 66 R is Me; Q² is Ph(2-c-Pr); and Q¹ is 67 R is Me; Q² is Ph(2-c-Pr,3-F); and Q¹ is 68 R is Me; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 69 R is Me; Q² is Ph(2-c-Pr,4-F); and Q¹ is 70 R is Me; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 71 R is Me; Q² is Ph(2-NO₂); and Q¹ is 72 R is Me; Q² is Ph(2-NO₂,3-F); and Q¹ is 73 R is Me; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 74 R is Me; Q² is Ph(2-NO₂,4-F); and Q¹ is 75 R is Me; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 76 R is Me; Q² is Ph(2-OCF₃); and Q¹ is 77 R is Me; Q² is Ph(2-OCF₃,3-F); and Q¹ is 78 R is Me; Q² is Ph(2-OCF₃,4-F); and Q¹ is 79 R is Me; Q² is Ph(2-Cl); and Q¹ is 80 R is Me; Q² is Ph(2-Cl,3-Me); and Q¹ is 81 R is Me; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 82 R is Me; Q² is Ph(2,3-di-Cl); and Q¹ is 83 R is Me; Q² is Ph(2,4-di-Cl); and Q¹ is 84 R is Me; Q² is Ph(2-Cl,3-F); and Q¹ is 85 R is Me; Q² is Ph(2-Cl,4-F); and Q¹ is 86 R is Me; Q² is Ph(2-Cl,5-F); and Q¹ is 87 R is Me; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 88 R is Me; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 89 R is Me; Q² is Ph(2-OCF₂H); and Q¹ is 90 R is Me; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 91 R is Me; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 92 R is Me; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 93 R is Me; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 94 R is Me; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 95 R is Me; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 96 R is Me; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 97 R is Me; Q² is Ph(2-Br); and Q¹ is 98 R is Me; Q² is Ph(2-Br,3-F); and Q¹ is 99 R is Me; Q² is Ph(2-Br,4-F); and Q¹ is 100 R is Me; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 101 R is Me; Q² is Ph(2-I); and Q¹ is 102 R is Me; Q² is Ph(2-I,3-F); and Q¹ is 103 R is Me; Q² is Ph(2-I,4-F); and Q¹ is 104 R is Me; Q² is Ph(2-I,3,4-di-F); and Q¹ is 105 R is Me; Q² is Ph(2-CN); and Q¹ is 106 R is Me; Q² is Ph(2-CN,3-Me); and Q¹ is 107 R is Me; Q² is Ph(2-CN,3-F); and Q¹ is 108 R is Me; Q² is Ph(2-CN,4-F); and Q¹ is 109 R is Me; Q² is Ph(2-CN,3-Cl); and Q¹ is 110 R is Me; Q² is Ph(2-CN,4-Cl); and Q¹ is 111 R is Me; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 112 R is Me; Q² is 2-Pyridinyl; and Q¹ is 113 R is Me; Q² is 2-Pyridinyl,3-F; and Q¹ is 114 R is Me; Q² is 2-Pyridinyl,4-F; and Q¹ is 115 R is Me; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 116 R is Me; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 117 R is Me; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 118 R is Me; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 119 R is Me; Q² is Ph(2-SO₂Me); and Q¹ is 120 R is Me; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 121 R is Me; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 122 R is Me; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 123 R is Me; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 124 R is Me; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 125 R is Me; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 126 R is Me; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 127 R is Me; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 128 R is Me; Q² is Ph(2-SO₂NH₂); and Q¹ is 129 R is Me; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 130 R is Me; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 131 R is Me; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 132 R is Me; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 133 R is Me; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 134 R is Me; Q² is Ph(3-F); and Q¹ is 135 R is Me; Q² is Ph(3,4-di-F); and Q¹ is 136 R is Me; Q² is Ph(3,5-di-F); and Q¹ is 137 R is Me; Q² is Ph(3,4,5-tri-F); and Q¹ is 138 R is Me; Q² is Ph(3-F,4-Cl); and Q¹ is 139 R is Me; Q² is Ph(3-CF₃); and Q¹ is 140 R is Me; Q² is Ph(3-CF₃,4-F); and Q¹ is 141 R is Me; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 142 R is Me; Q² is Ph(3-CF₃,5-F); and Q¹ is 143 R is Me; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 144 R is Me; Q² is Ph(3-SO₂Me); and Q¹ is 145 R is Me; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 146 R is Me; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 147 R is Me; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 148 R is Me; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 149 R is Me; Q² is Ph(3-SO₂NH₂); and Q¹ is 150 R is Me; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 151 R is Me; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 152 R is Me; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 153 R is Me; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 154 R is Me; Q² is Ph(3-Me); and Q¹ is 155 R is Me; Q² is Ph(3-Me,4-F); and Q¹ is 156 R is Me; Q² is Ph(3-Me,4-Cl); and Q¹ is 157 R is Me; Q² is Ph(3-Me,5-F); and Q¹ is 158 R is Me; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 159 R is Me; Q² is Ph(3-Cl); and Q¹ is 160 R is Me; Q² is Ph(3-Cl,4-F); and Q¹ is 161 R is Me; Q² is Ph(3,4-di-Cl); and Q¹ is 162 R is Me; Q² is Ph(3-Cl,5-F); and Q¹ is 163 R is Me; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 164 R is Me; Q² is Ph(3,5-di-Cl); and Q¹ is 165 R is Me; Q² is Ph(4-F); and Q¹ is 166 R is Me; Q² is Ph(4-Cl); and Q¹ is 167 R is Me; Q² is 2,2-difluoro-1,3-benzodioxol-4-yl; and Q¹ is 168 R is Me; Q² is 2,2-difluoro-1,3-benzodioxol-5-yl; and Q¹ is 169 R is Me; Q² is 2,2-dimethyl-1,3-benzodioxol-4-yl; and Q¹ is 170 R is Me; Q² is 2,2-dimethyl-1,3-benzodioxol-5-yl; and Q¹ is 171 R is Me; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 172 R is Me; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 173 R is Et; Q² is Ph(2-F); and Q¹ is 174 R is Et; Q² is Ph(2,3-diF); and Q¹ is 175 R is Et; Q² is Ph(2,4-diF); and Q¹ is 176 R is Et; Q² is Ph(2,5-di-F); and Q¹ is 177 R is Et; Q² is Ph(2,3,4-tri-F); and Q¹ is 178 R is Et; Q² is Ph(2,3,5-tri-F); and Q¹ is 179 R is Et; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 180 R is Et; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 181 R is Et; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 182 R is Et; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 183 R is Et; Q² is Ph(2-F,3-Me); and Q¹ is 184 R is Et; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 185 R is Et; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 186 R is Et; Q² is Ph(2-F,3-Cl); and Q¹ is 187 R is Et; Q² is Ph(2-F,4-Cl); and Q¹ is 188 R is Et; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 189 R is Et; Q² is Ph(2-F,4-Br); and Q¹ is 190 R is Et; Q² is Ph(2-F,3-OMe); and Q¹ is 191 R is Et; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 192 R is Et; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 193 R is Et; Q² is Ph(2-F,3-CF₂H); and Q¹ is 194 R is Et; Q² is Ph(2-F,3-CF₃); and Q¹ is 195 R is Et; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 196 R is Et; Q² is Ph(2-F,3-NO₂); and Q¹ is 197 R is Et; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 198 R is Et; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 199 R is Et; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 200 R is Et; Q² is Ph(2-CF₃); and Q¹ is 201 R is Et; Q² is Ph(2-CF₃,3-F); and Q¹ is 202 R is Et; Q² is Ph(2-CF₃,3-Me); and Q¹ is 203 R is Et; Q² is Ph(2-CF₃,4-F); and Q¹ is 204 R is Et; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 205 R is Et; Q² is Ph(2-CF₃,4-F); and Q¹ is 206 R is Et; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 207 R is Et; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 208 R is Et; Q² is Ph(2-CF₂H); and Q¹ is 209 R is Et; Q² is Ph(2-CF₂H,3-F); and Q¹ is 210 R is Et; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 211 R is Et; Q² is Ph(2-CF₂H,4-F); and Q¹ is 212 R is Et; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 213 R is Et; Q² is Ph(2-CF₂H,4-F); and Q¹ is 214 R is Et; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 215 R is Et; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 216 R is Et; Q² is Ph(2-Me); and Q¹ is 217 R is Et; Q² is Ph(2,3-di-Me); and Q¹ is 218 R is Et; Q² is Ph(2-Me,3-F); and Q¹ is 219 R is Et; Q² is Ph(2-Me,3-Cl); and Q¹ is 220 R is Et; Q² is Ph(2-Me,3-CF₃); and Q¹ is 221 R is Et; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 222 R is Et; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 223 R is Et; Q² is Ph(2-Me,4-Cl); and Q¹ is 224 R is Et; Q² is Ph(2-Me,4-F); and Q¹ is 225 R is Et; Q² is Ph(2-Me,5-F); and Q¹ is 226 R is Et; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 227 R is Et; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 228 R is Et; Q² is Ph(2-Et); and Q¹ is 229 R is Et; Q² is Ph(2-Et,3-F); and Q¹ is 230 R is Et; Q² is Ph(2-Et,3-Cl); and Q¹ is 231 R is Et; Q² is Ph(2-Et,4-F); and Q¹ is 232 R is Et; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 233 R is Et; Q² is Ph(2-i-Pr); and Q¹ is 234 R is Et; Q² is Ph(2-i-Pr,3-F); and Q¹ is 235 R is Et; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 236 R is Et; Q² is Ph(2-i-Pr,4-F); and Q¹ is 237 R is Et; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 238 R is Et; Q² is Ph(2-c-Pr); and Q¹ is 239 R is Et; Q² is Ph(2-c-Pr,3-F); and Q¹ is 240 R is Et; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 241 R is Et; Q² is Ph(2-c-Pr,4-F); and Q¹ is 242 R is Et; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 243 R is Et; Q² is Ph(2-NO₂); and Q¹ is 244 R is Et; Q² is Ph(2-NO₂,3-F); and Q¹ is 245 R is Et; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 246 R is Et; Q² is Ph(2-NO₂,4-F); and Q¹ is 247 R is Et; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 248 R is Et; Q² is Ph(2-OCF₃); and Q¹ is 249 R is Et; Q² is Ph(2-OCF₃,3-F); and Q¹ is 250 R is Et; Q² is Ph(2-OCF₃,4-F); and Q¹ is 251 R is Et; Q² is Ph(2-Cl); and Q¹ is 252 R is Et; Q² is Ph(2-Cl,3-Me); and Q¹ is 253 R is Et; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 254 R is Et; Q² is Ph(2,3-di-Cl); and Q¹ is 255 R is Et; Q² is Ph(2,4-di-Cl); and Q¹ is 256 R is Et; Q² is Ph(2-Cl,3-F); and Q¹ is 257 R is Et; Q² is Ph(2-Cl,4-F); and Q¹ is 258 R is Et; Q² is Ph(2-Cl,5-F); and Q¹ is 259 R is Et; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 260 R is Et; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 261 R is Et; Q² is Ph(2-OCF₂H); and Q¹ is 262 R is Et; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 263 R is Et; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 264 R is Et; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 265 R is Et; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 266 R is Et; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 267 R is Et; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 268 R is Et; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 269 R is Et; Q² is Ph(2-Br); and Q¹ is 270 R is Et; Q² is Ph(2-Br,3-F); and Q¹ is 271 R is Et; Q² is Ph(2-Br,4-F); and Q¹ is 272 R is Et; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 273 R is Et; Q² is Ph(2-I); and Q¹ is 274 R is Et; Q² is Ph(2-I,3-F); and Q¹ is 275 R is Et; Q² is Ph(2-I,4-F); and Q¹ is 276 R is Et; Q² is Ph(2-I,3,4-di-F); and Q¹ is 277 R is Et; Q² is Ph(2-CN); and Q¹ is 278 R is Et; Q² is Ph(2-CN,3-Me); and Q¹ is 279 R is Et; Q² is Ph(2-CN,3-F); and Q¹ is 280 R is Et; Q² is Ph(2-CN,4-F); and Q¹ is 281 R is Et; Q² is Ph(2-CN,3-Cl); and Q¹ is 282 R is Et; Q² is Ph(2-CN,4-Cl); and Q¹ is 283 R is Et; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 284 R is Et; Q² is 2-Pyridyl; and Q¹ is 285 R is Et; Q² is 2-Pyridyl,3-F; and Q¹ is 286 R is Et; Q² is 2-Pyridyl,4-F; and Q¹ is 287 R is Et; Q² is 2-Pyridyl,3,4-di-F; and Q¹ is 288 R is Et; Q² is 2-Pyridyl,3-Cl; and Q¹ is 289 R is Et; Q² is 2-Pyridyl,4-Cl; and Q¹ is 290 R is Et; Q² is 2-Pyridyl,3-Cl,4-F; and Q¹ is 291 R is Et; Q² is Ph(2-SO₂Me); and Q¹ is 292 R is Et; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 293 R is Et; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 294 R is Et; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 295 R is Et; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 296 R is Et; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 297 R is Et; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 298 R is Et; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 299 R is Et; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 300 R is Et; Q² is Ph(2-SO₂NH₂); and Q¹ is 301 R is Et; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 302 R is Et; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 303 R is Et; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 304 R is Et; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 305 R is Et; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 306 R is Et; Q² is Ph(3-F); and Q¹ is 307 R is Et; Q² is Ph(3,4-di-F); and Q¹ is 308 R is Et; Q² is Ph(3,5-di-F); and Q¹ is 309 R is Et; Q² is Ph(3,4,5-tri-F); and Q¹ is 310 R is Et; Q² is Ph(3-F,4-Cl); and Q¹ is 311 R is Et; Q² is Ph(3-CF₃); and Q¹ is 312 R is Et; Q² is Ph(3-CF₃,4-F); and Q¹ is 313 R is Et; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 314 R is Et; Q² is Ph(3-CF₃,5-F); and Q¹ is 315 R is Et; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 316 R is Et; Q² is Ph(3-SO₂Me); and Q¹ is 317 R is Et; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 318 R is Et; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 319 R is Et; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 320 R is Et; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 321 R is Et; Q² is Ph(3-SO₂NH₂); and Q¹ is 322 R is Et; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 323 R is Et; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 324 R is Et; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 325 R is Et; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 326 R is Et; Q² is Ph(3-Me); and Q¹ is 327 R is Et; Q² is Ph(3-Me,4-F); and Q¹ is 328 R is Et; Q² is Ph(3-Me,4-Cl); and Q¹ is 329 R is Et; Q² is Ph(3-Me,5-F); and Q¹ is 330 R is Et; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 331 R is Et; Q² is Ph(3-Cl); and Q¹ is 332 R is Et; Q² is Ph(3-Cl,4-F); and Q¹ is 333 R is Et; Q² is Ph(3,4-di-Cl); and Q¹ is 334 R is Et; Q² is Ph(3-Cl,5-F); and Q¹ is 335 R is Et; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 336 R is Et; Q² is Ph(3,5-di-Cl); and Q¹ is 337 R is Et; Q² is Ph(4-F); and Q¹ is 338 R is Et; Q² is Ph(4-Cl); and Q¹ is 339 R is Et; Q² is 2,2-difluoro-1,3-benzodioxol-4-yl; and Q¹ is 340 R is Et; Q² is 2,2-difluoro-1,3-benzodioxol-5-yl; and Q¹ is 341 R is Et; Q² is 2,2-dimethyl-1,3-benzodioxol-4-yl; and Q¹ is 342 R is Et; Q² is 2,2-dimethyl-1,3-benzodioxol-5-yl; and Q¹ is 343 R is Et; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 344 R is Et; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 345 R is Ph; Q² is Ph(2-F); and Q¹ is 346 R is Ph; Q² is Ph(2,3-diF); and Q¹ is 347 R is Ph; Q² is Ph(2,4-diF); and Q¹ is 348 R is Ph; Q² is Ph(2,5-di-F); and Q¹ is 349 R is Ph; Q² is Ph(2,3,4-tri-F); and Q¹ is 350 R is Ph; Q² is Ph(2,3,5-tri-F); and Q¹ is 351 R is Ph; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 352 R is Ph; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 353 R is Ph; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 354 R is Ph; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 355 R is Ph; Q² is Ph(2-F,3-Me); and Q¹ is 356 R is Ph; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 357 R is Ph; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 358 R is Ph; Q² is Ph(2-F,3-Cl); and Q¹ is 359 R is Ph; Q² is Ph(2-F,4-Cl); and Q¹ is 360 R is Ph; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 361 R is Ph; Q² is Ph(2-F,4-Br); and Q¹ is 362 R is Ph; Q² is Ph(2-F,3-OMe); and Q¹ is 363 R is Ph; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 364 R is Ph; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 365 R is Ph; Q² is Ph(2-F,3-CF₂H); and Q¹ is 366 R is Ph; Q² is Ph(2-F,3-CF₃); and Q¹ is 367 R is Ph; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 368 R is Ph; Q² is Ph(2-F,3-NO₂); and Q¹ is 369 R is Ph; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 370 R is Ph; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 371 R is Ph; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 372 R is Ph; Q² is Ph(2-CF₃); and Q¹ is 373 R is Ph; Q² is Ph(2-CF₃,3-F); and Q¹ is 374 R is Ph; Q² is Ph(2-CF₃,3-Me); and Q¹ is 375 R is Ph; Q² is Ph(2-CF₃,4-F); and Q¹ is 376 R is Ph; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 377 R is Ph; Q² is Ph(2-CF₃,4-F); and Q¹ is 378 R is Ph; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 379 R is Ph; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 380 R is Ph; Q² is Ph(2-CF₂H); and Q¹ is 381 R is Ph; Q² is Ph(2-CF₂H,3-F); and Q¹ is 382 R is Ph; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 383 R is Ph; Q² is Ph(2-CF₂H,4-F); and Q¹ is 384 R is Ph; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 385 R is Ph; Q² is Ph(2-CF₂H,4-F); and Q¹ is 386 R is Ph; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 387 R is Ph; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 388 R is Ph; Q² is Ph(2-Me); and Q¹ is 389 R is Ph; Q² is Ph(2,3-di-Me); and Q¹ is 390 R is Ph; Q² is Ph(2-Me,3-F); and Q¹ is 391 R is Ph; Q² is Ph(2-Me,3-Cl); and Q¹ is 392 R is Ph; Q² is Ph(2-Me,3-CF₃); and Q¹ is 393 R is Ph; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 394 R is Ph; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 395 R is Ph; Q² is Ph(2-Me,4-Cl); and Q¹ is 396 R is Ph; Q² is Ph(2-Me,4-F); and Q¹ is 397 R is Ph; Q² is Ph(2-Me,5-F); and Q¹ is 398 R is Ph; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 399 R is Ph; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 400 R is Ph; Q² is Ph(2-Et); and Q¹ is 401 R is Ph; Q² is Ph(2-Et,3-F); and Q¹ is 402 R is Ph; Q² is Ph(2-Et,3-Cl); and Q¹ is 403 R is Ph; Q² is Ph(2-Et,4-F); and Q¹ is 404 R is Ph; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 405 R is Ph; Q² is Ph(2-i-Pr); and Q¹ is 406 R is Ph; Q² is Ph(2-i-Pr,3-F); and Q¹ is 407 R is Ph; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 408 R is Ph; Q² is Ph(2-i-Pr,4-F); and Q¹ is 409 R is Ph; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 410 R is Ph; Q² is Ph(2-c-Pr); and Q¹ is 411 R is Ph; Q² is Ph(2-c-Pr,3-F); and Q¹ is 412 R is Ph; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 413 R is Ph; Q² is Ph(2-c-Pr,4-F); and Q¹ is 414 R is Ph; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 415 R is Ph; Q² is Ph(2-NO₂); and Q¹ is 416 R is Ph; Q² is Ph(2-NO₂,3-F); and Q¹ is 417 R is Ph; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 418 R is Ph; Q² is Ph(2-NO₂,4-F); and Q¹ is 419 R is Ph; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 420 R is Ph; Q² is Ph(2-OCF₃); and Q¹ is 421 R is Ph; Q² is Ph(2-OCF₃,3-F); and Q¹ is 422 R is Ph; Q² is Ph(2-OCF₃,4-F); and Q¹ is 423 R is Ph; Q² is Ph(2-Cl); and Q¹ is 424 R is Ph; Q² is Ph(2-Cl,3-Me); and Q¹ is 425 R is Ph; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 426 R is Ph; Q² is Ph(2,3-di-Cl); and Q¹ is 427 R is Ph; Q² is Ph(2,4-di-Cl); and Q¹ is 428 R is Ph; Q² is Ph(2-Cl,3-F); and Q¹ is 429 R is Ph; Q² is Ph(2-Cl,4-F); and Q¹ is 430 R is Ph; Q² is Ph(2-Cl,5-F); and Q¹ is 431 R is Ph; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 432 R is Ph; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 433 R is Ph; Q² is Ph(2-OCF₂H); and Q¹ is 434 R is Ph; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 435 R is Ph; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 436 R is Ph; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 437 R is Ph; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 438 R is Ph; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 439 R is Ph; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 440 R is Ph; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 441 R is Ph; Q² is Ph(2-Br); and Q¹ is 442 R is Ph; Q² is Ph(2-Br,3-F); and Q¹ is 443 R is Ph; Q² is Ph(2-Br,4-F); and Q¹ is 444 R is Ph; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 445 R is Ph; Q² is Ph(2-I); and Q¹ is 446 R is Ph; Q² is Ph(2-I,3-F); and Q¹ is 447 R is Ph; Q² is Ph(2-I,4-F); and Q¹ is 448 R is Ph; Q² is Ph(2-I,3,4-di-F); and Q¹ is 449 R is Ph; Q² is Ph(2-CN); and Q¹ is 450 R is Ph; Q² is Ph(2-CN,3-Me); and Q¹ is 451 R is Ph; Q² is Ph(2-CN,3-F); and Q¹ is 452 R is Ph; Q² is Ph(2-CN,4-F); and Q¹ is 453 R is Ph; Q² is Ph(2-CN,3-Cl); and Q¹ is 454 R is Ph; Q² is Ph(2-CN,4-Cl); and Q¹ is 455 R is Ph; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 456 R is Ph; Q² is 2-Pyridinyl; and Q¹ is 457 R is Ph; Q² is 2-Pyridinyl,3-F; and Q¹ is 458 R is Ph; Q² is 2-Pyridinyl,4-F; and Q¹ is 459 R is Ph; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 460 R is Ph; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 461 R is Ph; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 462 R is Ph; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 463 R is Ph; Q² is Ph(2-SO₂Me); and Q¹ is 464 R is Ph; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 465 R is Ph; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 466 R is Ph; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 467 R is Ph; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 468 R is Ph; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 469 R is Ph; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 470 R is Ph; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 471 R is Ph; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 472 R is Ph; Q² is Ph(2-SO₂NH₂); and Q¹ is 473 R is Ph; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 474 R is Ph; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 475 R is Ph; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 476 R is Ph; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 477 R is Ph; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 478 R is Ph; Q² is Ph(3-F); and Q¹ is 479 R is Ph; Q² is Ph(3,4-di-F); and Q¹ is 480 R is Ph; Q² is Ph(3,5-di-F); and Q¹ is 481 R is Ph; Q² is Ph(3,4,5-tri-F); and Q¹ is 482 R is Ph; Q² is Ph(3-F,4-Cl); and Q¹ is 483 R is Ph; Q² is Ph(3-CF₃); and Q¹ is 484 R is Ph; Q² is Ph(3-CF₃,4-F); and Q¹ is 485 R is Ph; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 486 R is Ph; Q² is Ph(3-CF₃,5-F); and Q¹ is 487 R is Ph; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 488 R is Ph; Q² is Ph(3-SO₂Me); and Q¹ is 489 R is Ph; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 490 R is Ph; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 491 R is Ph; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 492 R is Ph; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 493 R is Ph; Q² is Ph(3-SO₂NH₂); and Q¹ is 494 R is Ph; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 495 R is Ph; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 496 R is Ph; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 497 R is Ph; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 498 R is Ph; Q² is Ph(3-Me); and Q¹ is 499 R is Ph; Q² is Ph(3-Me,4-F); and Q¹ is 500 R is Ph; Q² is Ph(3-Me,4-Cl); and Q¹ is 501 R is Ph; Q² is Ph(3-Me,5-F); and Q¹ is 502 R is Ph; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 503 R is Ph; Q² is Ph(3-Cl); and Q¹ is 504 R is Ph; Q² is Ph(3-Cl,4-F); and Q¹ is 505 R is Ph; Q² is Ph(3,4-di-Cl); and Q¹ is 506 R is Ph; Q² is Ph(3-Cl,5-F); and Q¹ is 507 R is Ph; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 508 R is Ph; Q² is Ph(3,5-di-Cl); and Q¹ is 509 R is Ph; Q² is Ph(4-F); and Q¹ is 510 R is Ph; Q² is Ph(4-Cl); and Q¹ is 511 R is Ph; Q² is 2,2-difluoro-1,3-benzodioxol-4-yl; and Q¹ is 512 R is Ph; Q² is 2,2-difluoro-1,3-benzodioxol-5-yl; and Q¹ is 513 R is Ph; Q² is 2,2-dimethyl-1,3-benzodioxol-4-yl; and Q¹ is 514 R is Ph; Q² is 2,2-dimethyl-1,3-benzodioxol-5-yl; and Q¹ is 515 R is Ph; Q² is l,3-benzodioxol-4-yl; and Q¹ is 516 R is Ph; Q² is l,3-benzodioxol-5-yl; and Q¹ is 517 R is t-Bu; Q² is Ph(2-F); and Q¹ is 518 R is t-Bu; Q² is Ph(2,3-diF); and Q¹ is 519 R is t-Bu; Q² is Ph(2,4-diF); and Q¹ is 520 R is t-Bu; Q² is Ph(2,5-di-F); and Q¹ is 521 R is t-Bu; Q² is Ph(2,3,4-tri-F); and Q¹ is 522 R is t-Bu; Q² is Ph(2,3,5-tri-F); and Q¹ is 523 R is t-Bu; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 524 R is t-Bu; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 525 R is t-Bu; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 526 R is t-Bu; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 527 R is t-Bu; Q² is Ph(2-F,3-Me); and Q¹ is 528 R is t-Bu; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 529 R is t-Bu; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 530 R is t-Bu; Q² is Ph(2-F,3-Cl); and Q¹ is 531 R is t-Bu; Q² is Ph(2-F,4-Cl); and Q¹ is 532 R is t-Bu; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 533 R is t-Bu; Q² is Ph(2-F,4-Br); and Q¹ is 534 R is t-Bu; Q² is Ph(2-F,3-OMe); and Q¹ is 535 R is t-Bu; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 536 R is t-Bu; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 537 R is t-Bu; Q² is Ph(2-F,3-CF₂H); and Q¹ is 538 R is t-Bu; Q² is Ph(2-F,3-CF₃); and Q¹ is 539 R is t-Bu; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 540 R is t-Bu; Q² is Ph(2-F,3-NO₂); and Q¹ is 541 R is t-Bu; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 542 R is t-Bu; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 543 R is t-Bu; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 544 R is t-Bu; Q² is Ph(2-CF₃); and Q¹ is 545 R is t-Bu; Q² is Ph(2-CF₃,3-F); and Q¹ is 546 R is t-Bu; Q² is Ph(2-CF₃,3-Me); and Q¹ is 547 R is t-Bu; Q² is Ph(2-CF₃,4-F); and Q¹ is 548 R is t-Bu; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 549 R is t-Bu; Q² is Ph(2-CF₃,4-F); and Q¹ is 550 R is t-Bu; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 551 R is t-Bu; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 552 R is t-Bu; Q² is Ph(2-CF₂H); and Q¹ is 553 R is t-Bu; Q² is Ph(2-CF₂H,3-F); and Q¹ is 554 R is t-Bu; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 555 R is t-Bu; Q² is Ph(2-CF₂H,4-F); and Q¹ is 556 R is t-Bu; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 557 R is t-Bu; Q² is Ph(2-CF₂H,4-F); and Q¹ is 558 R is t-Bu; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 559 R is t-Bu; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 560 R is t-Bu; Q² is Ph(2-Me); and Q¹ is 561 R is t-Bu; Q² is Ph(2,3-di-Me); and Q¹ is 562 R is t-Bu; Q² is Ph(2-Me,3-F); and Q¹ is 563 R is t-Bu; Q² is Ph(2-Me,3-Cl); and Q¹ is 564 R is t-Bu; Q² is Ph(2-Me,3-CF₃); and Q¹ is 565 R is t-Bu; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 566 R is t-Bu; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 567 R is t-Bu; Q² is Ph(2-Me,4-Cl); and Q¹ is 568 R is t-Bu; Q² is Ph(2-Me,4-F); and Q¹ is 569 R is t-Bu; Q² is Ph(2-Me,5-F); and Q¹ is 570 R is t-Bu; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 571 R is t-Bu; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 572 R is t-Bu; Q² is Ph(2-Et); and Q¹ is 573 R is t-Bu; Q² is Ph(2-Et,3-F); and Q¹ is 574 R is t-Bu; Q² is Ph(2-Et,3-Cl); and Q¹ is 575 R is t-Bu; Q² is Ph(2-Et,4-F); and Q¹ is 576 R is t-Bu; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 577 R is t-Bu; Q² is Ph(2-i-Pr); and Q¹ is 578 R is t-Bu; Q² is Ph(2-i-Pr,3-F); and Q¹ is 579 R is t-Bu; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 580 R is t-Bu; Q² is Ph(2-i-Pr,4-F); and Q¹ is 581 R is t-Bu; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 582 R is t-Bu; Q² is Ph(2-c-Pr); and Q¹ is 583 R is t-Bu; Q² is Ph(2-c-Pr,3-F); and Q¹ is 584 R is t-Bu; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 585 R is t-Bu; Q² is Ph(2-c-Pr,4-F); and Q¹ is 586 R is t-Bu; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 587 R is t-Bu; Q² is Ph(2-NO₂); and Q¹ is 588 R is t-Bu; Q² is Ph(2-NO₂,3-F); and Q¹ is 589 R is t-Bu; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 590 R is t-Bu; Q² is Ph(2-NO₂,4-F); and Q¹ is 591 R is t-Bu; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 592 R is t-Bu; Q² is Ph(2-OCF₃); and Q¹ is 593 R is t-Bu; Q² is Ph(2-OCF₃,3-F); and Q¹ is 594 R is t-Bu; Q² is Ph(2-OCF₃,4-F); and Q¹ is 595 R is t-Bu; Q² is Ph(2-Cl); and Q¹ is 596 R is t-Bu; Q² is Ph(2-Cl,3-Me); and Q¹ is 597 R is t-Bu; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 598 R is t-Bu; Q² is Ph(2,3-di-Cl); and Q¹ is 599 R is t-Bu; Q² is Ph(2,4-di-Cl); and Q¹ is 600 R is t-Bu; Q² is Ph(2-Cl,3-F); and Q¹ is 601 R is t-Bu; Q² is Ph(2-Cl,4-F); and Q¹ is 602 R is t-Bu; Q² is Ph(2-Cl,5-F); and Q¹ is 603 R is t-Bu; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 604 R is t-Bu; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 605 R is t-Bu; Q² is Ph(2-OCF₂H); and Q¹ is 606 R is t-Bu; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 607 R is t-Bu; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 608 R is t-Bu; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 609 R is t-Bu; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 610 R is t-Bu; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 611 R is t-Bu; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 612 R is t-Bu; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 613 R is t-Bu; Q² is Ph(2-Br); and Q¹ is 614 R is t-Bu; Q² is Ph(2-Br,3-F); and Q¹ is 615 R is t-Bu; Q² is Ph(2-Br,4-F); and Q¹ is 616 R is t-Bu; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 617 R is t-Bu; Q² is Ph(2-I); and Q¹ is 618 R is t-Bu; Q² is Ph(2-I,3-F); and Q¹ is 619 R is t-Bu; Q² is Ph(2-I,4-F); and Q¹ is 620 R is t-Bu; Q² is Ph(2-I,3,4-di-F); and Q¹ is 621 R is t-Bu; Q² is Ph(2-CN); and Q¹ is 622 R is t-Bu; Q² is Ph(2-CN,3-Me); and Q¹ is 623 R is t-Bu; Q² is Ph(2-CN,3-F); and Q¹ is 624 R is t-Bu; Q² is Ph(2-CN,4-F); and Q¹ is 625 R is t-Bu; Q² is Ph(2-CN,3-Cl); and Q¹ is 626 R is t-Bu; Q² is Ph(2-CN,4-Cl); and Q¹ is 627 R is t-Bu; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 628 R is t-Bu; Q² is 2-Pyridinyl; and Q¹ is 629 R is t-Bu; Q² is 2-Pyridinyl,3-F; and Q¹ is 630 R is t-Bu; Q² is 2-Pyridinyl,4-F; and Q¹ is 631 R is t-Bu; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 632 R is t-Bu; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 633 R is t-Bu; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 634 R is t-Bu; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 635 R is t-Bu; Q² is Ph(2-SO₂Me); and Q¹ is 636 R is t-Bu; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 637 R is t-Bu; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 638 R is t-Bu; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 639 R is t-Bu; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 640 R is t-Bu; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 641 R is t-Bu; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 642 R is t-Bu; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 643 R is t-Bu; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 644 R is t-Bu; Q² is Ph(2-SO₂NH₂); and Q¹ is 645 R is t-Bu; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 646 R is t-Bu; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 647 R is t-Bu; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 648 R is t-Bu; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 649 R is t-Bu; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 650 R is t-Bu; Q² is Ph(3-F); and Q¹ is 651 R is t-Bu; Q² is Ph(3,4-di-F); and Q¹ is 652 R is t-Bu; Q² is Ph(3,5-di-F); and Q¹ is 653 R is t-Bu; Q² is Ph(3,4,5-tri-F); and Q¹ is 654 R is t-Bu; Q² is Ph(3-F,4-Cl); and Q¹ is 655 R is t-Bu; Q² is Ph(3-CF₃); and Q¹ is 656 R is t-Bu; Q² is Ph(3-CF₃,4-F); and Q¹ is 657 R is t-Bu; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 658 R is t-Bu; Q² is Ph(3-CF₃,5-F); and Q¹ is 659 R is t-Bu; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 660 R is t-Bu; Q² is Ph(3-SO₂Me); and Q¹ is 661 R is t-Bu; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 662 R is t-Bu; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 663 R is t-Bu; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 664 R is t-Bu; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 665 R is t-Bu; Q² is Ph(3-SO₂NH₂); and Q¹ is 666 R is t-Bu; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 667 R is t-Bu; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 668 R is t-Bu; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 669 R is t-Bu; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 670 R is t-Bu; Q² is Ph(3-Me); and Q¹ is 671 R is t-Bu; Q² is Ph(3-Me,4-F); and Q¹ is 672 R is t-Bu; Q² is Ph(3-Me,4-Cl); and Q¹ is 673 R is t-Bu; Q² is Ph(3-Me,5-F); and Q¹ is 674 R is t-Bu; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 675 R is t-Bu; Q² is Ph(3-Cl); and Q¹ is 676 R is t-Bu; Q² is Ph(3-Cl,4-F); and Q¹ is 677 R is t-Bu; Q² is Ph(3,4-di-Cl); and Q¹ is 678 R is t-Bu; Q² is Ph(3-Cl,5-F); and Q¹ is 679 R is t-Bu; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 680 R is t-Bu; Q² is Ph(3,5-di-Cl); and Q¹ is 681 R is t-Bu; Q² is Ph(4-F); and Q¹ is 682 R is t-Bu; Q² is Ph(4-Cl); and Q¹ is 683 R is t-Bu; Q² is 2,2-difluoro-1,3-benzodioxol-4-yl; and Q¹ is 684 R is t-Bu; Q² is 2,2-difluoro-1,3-benzodioxol-5-yl; and Q¹ is 685 R is t-Bu; Q² is 2,2-dimethyl-1,3-benzodioxol-4-yl; and Q¹ is 686 R is t-Bu; Q² is 2,2-dimethyl-1,3-benzodioxol-5-yl; and Q¹ is 687 R is t-Bu; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 688 R is t-Bu; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 

What is claimed is:
 1. A compound selected from Formula I and salts thereof,

wherein Q¹ is a phenyl ring or a naphthalenyl ring system, each ring or ring system optionally substituted with up to 5 substituents independently selected from R¹; or a 5- to 6-membered fully unsaturated heterocyclic ring or an 8- to 10-membered heteroaromatic bicyclic ring system, each ring or ring system containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 3 carbon ring members are independently selected from C(═O) and C(═S), and the sulfur atom ring members are independently selected from S(═O)_(u)(═NR²)_(v), each ring or ring system optionally substituted with up to 5 substituents independently selected from R¹ on carbon atom ring members and selected from R³ on nitrogen atom ring members; Q² is a phenyl ring or a naphthalenyl ring system, each ring or ring system optionally substituted with up to 5 substituents independently selected from R⁴; or a 5- to 6-membered fully unsaturated heterocyclic ring or an 8- to 10-membered heteroaromatic bicyclic ring system, each ring or ring system containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 3 carbon ring members are independently selected from C(═O) and C(═S), and the sulfur atom ring members are independently selected from S(═O)_(u)(═NR²)_(v), each ring or ring system optionally substituted with up to 5 substituents independently selected from R⁴ on carbon atom ring members and selected from R⁵ on nitrogen atom ring members; R is C₁-C₈ alkyl or phenyl; each R¹ and R⁴ is independently halogen, cyano, nitro, C₁-C₈ alkyl, C₁-C₈ haloalkyl, C₁-C₈ nitroalkyl, C₂-C₈ alkenyl, C₂-C₈ haloalkenyl, C₂-C₈ haloalkoxyalkoxy, C₂-C₈ nitroalkenyl, C₂-C₈ alkynyl, C₂-C₈ haloalkynyl, C₄-C₁₀ cycloalkylalkyl, C₄-C₁₀ halocycloalkylalkyl, C₅-C₁₂ alkylcycloalkylalkyl, C₅-C₁₂ cycloalkylalkenyl, C₅-C₁₂ cycloalkylalkynyl, C₃-C₈ cycloalkyl, C₃-C₈ halocycloalkyl, C₄-C₁₀ alkylcycloalkyl, C₆-C₁₂ cycloalkylcycloalkyl, C₃-C₈ cycloalkenyl, C₃-C₈ halocycloalkenyl, C₂-C₈ alkoxyalkyl, C₂-C₈ haloalkoxyalkyl, C₄-C₁₀ cycloalkoxyalkyl, C₃-C₁₀ alkoxyalkoxyalkyl, C₂-C₈ alkylthioalkyl, C₂-C₈ alkylsulfinylalkyl, C₂-C₈ alkylsulfonylalkyl, C₂-C₈ alkylaminoalkyl, C₂-C₈ haloalkylaminoalkyl, C₄-C₁₀ cycloalkylaminoalkyl, C₃-C₁₀ dialkylaminoalkyl, —CHO, C₂-C₈ alkylcarbonyl, C₂-C₈ haloalkylcarbonyl, C₄-C₁₀ cycloalkylcarbonyl, —C(═O)OH, C₂-C₈ alkoxycarbonyl, C₂-C₈ haloalkoxycarbonyl, C₄-C₁₀ cycloalkoxycarbonyl, C₅-C₁₂ cycloalkylalkoxycarbonyl, —C(═O)NH₂, C₂-C₈ alkylaminocarbonyl, C₄-C₁₀ cycloalkylaminocarbonyl, C₃-C₁₀ dialkylaminocarbonyl, C₁-C₈ alkoxy, C₁-C₈ haloalkoxy, C₂-C₈ alkoxyalkoxy, C₂-C₈ alkenyloxy, C₂-C₈ haloalkenyloxy, C₃-C₈ alkynyloxy, C₃-C₈ haloalkynyloxy, C₃-C₈ cycloalkoxy, C₃-C₈ halocycloalkoxy, C₄-C₁₀ cycloalkylalkoxy, C₃-C₁₀ alkylcarbonylalkoxy, C₂-C₈ alkylcarbonyloxy, C₂-C₈ haloalkylcarbonyloxy, C₄-C₁₀ cycloalkylcarbonyloxy, C₁-C₈ alkylsulfonyloxy, C₁-C₈ haloalkylsulfonyloxy, C₁-C₈ alkylthio, C₁-C₈ haloalkylthio, C₃-C₈ cycloalkylthio, C₁-C₈ alkylsulfinyl, C₁-C₈ haloalkylsulfinyl, C₁-C₈ alkylsulfonyl, C₁-C₈ haloalkylsulfonyl, C₃-C₈ cycloalkylsulfonyl, formylamino, C₂-C₈ alkylcarbonylamino, C₂-C₈ haloalkylcarbonylamino, C₂-C₈ alkoxycarbonylamino, C₁-C₆ alkylsulfonylamino, C₁-C₆ haloalkylsulfonylamino, —SF₅, —SCN, C₃-C₁₂ trialkylsilyl, C₄-C₁₂ trialkylsilylalkyl or C₄-C₁₂ trialkylsilylalkoxy; each R² is independently H, cyano, C₂-C₃ alkylcarbonyl or C₂-C₃ haloalkylcarbonyl; each R³ and R⁵ is independently cyano, C₁-C₃ alkyl, C₂-C₃ alkenyl, C₂-C₃ alkynyl, C₃-C₆ cycloalkyl, C₂-C₃ alkoxyalkyl, C₁-C₃ alkoxy, C₂-C₃ alkylcarbonyl, C₂-C₃ alkoxycarbonyl, C₂-C₃ alkylaminoalkyl, C₃-C₄ dialkylaminoalkyl or C₂-C₃ haloalkyl; and each u and v are independently 0, 1 or 2 in each instance of S(═O)_(u)(═NR²)_(v), provided that the sum of u and v is 0, 1 or
 2. 2. The compound of claim 1 wherein Q¹ is a phenyl ring substituted with 1 to 3 substituents independently selected from R¹; Q² is a phenyl ring substituted with 1 to 3 substituents independently selected from R⁴; R is C₁-C₄ alkyl; R¹ is independently halogen, cyano, nitro, C₁-C₈ alkyl, C₁-C₈ haloalkyl or C₂-C₈ haloalkoxyalkoxy; and R⁴ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl.
 3. The compound of claim 2 wherein Q¹ is a phenyl ring having a substituent selected from R¹ at the meta (3-) position and optionally up to 2 additional R¹ substituents; Q² is a phenyl ring having a substituent selected from R⁴ at the ortho (2-) position and optionally up to 2 additional R⁴ substituents; R is methyl or ethyl; R¹ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl; and R⁴ is independently halogen or C₁-C₃ haloalkyl.
 4. The compound of claim 2 wherein Q¹ is a phenyl ring having a substituent selected from R¹ at the para (4-) position and optionally up to 2 additional R¹ substituents; Q² is a phenyl ring having a substituent selected from R⁴ at the ortho (2-) position and optionally up to 2 additional R⁴ substituents; R is methyl or ethyl; R¹ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl; and R⁴ is independently halogen or C₁-C₃ haloalkyl.
 5. The compound of claim 1 wherein Q¹ is a 5- to 6-membered fully unsaturated heterocyclic ring optionally substituted with up to 5 substituents independently selected from R¹ on carbon atom ring members and selected from R³ on nitrogen atom ring members; Q² is a phenyl ring substituted with 1 to 3 substituents independently selected from R⁴; R is C₁-C₄ alkyl; R¹ is independently halogen, cyano, nitro, C₁-C₈ alkyl, C₁-C₈ haloalkyl or C₂-C₈ haloalkoxyalkoxy; R³ is independently C₁-C₃ alkyl, C₂-C₃ alkenyl, C₂-C₃ alkynyl, C₃-C₆ cycloalkyl or C₁-C₃ alkoxy; and R⁴ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl.
 6. The compound of claim 5 wherein Q¹ is a pyridyl ring optionally substituted with up to 2 R¹; Q² is a phenyl ring substituted with 1 to 2 substituents independently selected from R⁴; R is methyl or ethyl; R¹ is independently halogen or C₁-C₃ haloalkyl; and R⁴ is independently halogen or C₁-C₃ haloalkyl.
 7. The compound of claim 5 wherein Q¹ is a 3-pyridyl ring substituted with R¹ at the position para to the bond connecting Q¹ to the remainder of the compound of Formula I; or Q¹ is a thiophene or furan ring optionally substituted with up to 2 R¹; Q² is a phenyl ring substituted with 1 to 2 substituents independently selected from R⁴; R is methyl or ethyl; R¹ is independently halogen or C₁-C₃ haloalkyl; and R⁴ is independently halogen or C₁-C₃ haloalkyl.
 8. The compound of claim 1 wherein Q² is a 2-pyridyl or 3-pyridyl ring optionally substituted with up to 2 R⁴; R is methyl or ethyl; R¹ is independently halogen or C₁-C₃ haloalkyl; and R⁴ is independently halogen or C₁-C₃ haloalkyl.
 9. A method for preparing a compound of Formula I as defined in claim 1, comprising contacting a compound of Formula II

wherein Q¹ is as defined in claim 1, with a compound of Formula III

wherein R and Q² are as defined in claim 1, optionally in the presence of a catalyst or a base to form a compound of Formula I.
 10. The method of claim 9 wherein Q¹ is a phenyl ring substituted with 1 to 3 substituents independently selected from R¹; Q² is a phenyl ring substituted with 1 to 3 substituents independently selected from R⁴; R is C₁-C₄ alkyl; R¹ is independently halogen, cyano, nitro, C₁-C₈ alkyl, C₁-C₈ haloalkyl or C₂-C₈ haloalkoxyalkoxy; and R⁴ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl.
 11. The method of claim 10 wherein Q¹ is a phenyl ring having a substituent selected from R¹ at the meta (3-) position and optionally up to 2 additional R¹ substituents; Q² is a phenyl ring having a substituent selected from R⁴ at the ortho (2-) position and optionally up to 2 additional R⁴ substituents; R is methyl or ethyl; R¹ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl; and R⁴ is independently halogen or C₁-C₃ haloalkyl.
 12. The method of claim 10 wherein the catalyst is a nickel complex; and the base is an organic base.
 13. The method of claim 12 wherein the nickel complex is Ni(II) with chiral vicinal diamine ligands.
 14. The method of claim 13 wherein the ligands are N substituted cyclohexane-1,2 diamines or 1,1′-Bi(tetrahydroisoquinoline)-diamines; and the base is triethylamine, morpholine or piperidine.
 15. The method of claim 10 wherein the stereochemistry of the carbon center connecting Q¹ to the remainder of Formula I is S or R.
 16. A method for preparing a compound of Formula IV

wherein Q¹ is a phenyl ring or a naphthalenyl ring system, each ring or ring system optionally substituted with up to 5 substituents independently selected from R¹; or a 5- to 6-membered fully unsaturated heterocyclic ring or an 8- to 10-membered heteroaromatic bicyclic ring system, each ring or ring system containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 3 carbon ring members are independently selected from C(═O) and C(═S), and the sulfur atom ring members are independently selected from S(═O)_(u)(═NR²)_(v), each ring or ring system optionally substituted with up to 5 substituents independently selected from R¹ on carbon atom ring members and selected from R³ on nitrogen atom ring members; and Q² is a phenyl ring or a naphthalenyl ring system, each ring or ring system optionally substituted with up to 5 substituents independently selected from R⁴; or a 5- to 6-membered fully unsaturated heterocyclic ring or an 8- to 10-membered heteroaromatic bicyclic ring system, each ring or ring system containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 3 carbon ring members are independently selected from C(═O) and C(═S), and the sulfur atom ring members are independently selected from S(═O)_(u)(═NR²)_(v), each ring or ring system optionally substituted with up to 5 substituents independently selected from R⁴ on carbon atom ring members and selected from R⁵ on nitrogen atom ring members comprising reductively cyclizing a compound of Formula I

wherein Q¹ is a phenyl ring or a naphthalenyl ring system, each ring or ring system optionally substituted with up to 5 substituents independently selected from R¹; or a 5- to 6-membered fully unsaturated heterocyclic ring or an 8- to 10-membered heteroaromatic bicyclic ring system, each ring or ring system containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 3 carbon ring members are independently selected from C(═O) and C(═S), and the sulfur atom ring members are independently selected from S(═O)_(u)(═NR²)_(v), each ring or ring system optionally substituted with up to 5 substituents independently selected from R¹ on carbon atom ring members and selected from R³ on nitrogen atom ring members; Q² is a phenyl ring or a naphthalenyl ring system, each ring or ring system optionally substituted with up to 5 substituents independently selected from R⁴; or a 5- to 6-membered fully unsaturated heterocyclic ring or an 8- to 10-membered heteroaromatic bicyclic ring system, each ring or ring system containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 3 carbon ring members are independently selected from C(═O) and C(═S), and the sulfur atom ring members are independently selected from S(═O)_(u)(═NR²)_(v), each ring or ring system optionally substituted with up to 5 substituents independently selected from R⁴ on carbon atom ring members and selected from R⁵ on nitrogen atom ring members; and R is C₁-C₈ alkyl or phenyl; in the presence of a reducing agent.
 17. The method of claim 16 wherein Q¹ is a phenyl ring substituted with 1 to 3 substituents independently selected from R¹; Q² is a phenyl ring substituted with 1 to 3 substituents independently selected from R⁴; R is C₁-C₄ alkyl; R¹ is independently halogen, cyano, nitro, C₁-C₈ alkyl, C₁-C₈ haloalkyl or C₂-C₈ haloalkoxyalkoxy; and R⁴ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl.
 18. The method of claim 17 wherein Q¹ is a phenyl ring having a substituent selected from R¹ at the meta (3-) position and optionally up to 2 additional R¹ substituents; Q² is a phenyl ring having a substituent selected from R⁴ at the ortho (2-) position and optionally up to 2 additional R⁴ substituents; R¹ is independently halogen, C₁-C₃ alkyl or C₁-C₃ haloalkyl; R⁴ is independently halogen or C₁-C₃ haloalkyl.
 19. The method of claim 16 wherein Q¹ is a pyridyl ring optionally substituted with up to 2 R¹; Q² is a phenyl ring substituted with 1 to 3 substituents independently selected from R⁴; R¹ is independently halogen or C₁-C₃ haloalkyl; and R⁴ is independently halogen or C₁-C₃ haloalkyl.
 20. The method of claim 16 wherein the stereochemistry of a compound of Formula IV is (3R,4S) or (3S,4R).
 21. The compound of claim 1 that is ethyl a-[[2-fluorophenyl)amino]carbonyl]-(nitromethyl)-3-(trifluoromethyl)benzenepropanoate. 